ID   EBHA_STAAE              Reviewed;        3462 AA.
AC   A6QGY4;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Extracellular matrix-binding protein EbhA;
DE   AltName: Full=ECM-binding protein homolog A;
GN   Name=ebhA; OrderedLocusNames=NWMN_1344;
OS   Staphylococcus aureus (strain Newman).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=426430;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Newman;
RX   PubMed=17951380; DOI=10.1128/jb.01000-07;
RA   Baba T., Bae T., Schneewind O., Takeuchi F., Hiramatsu K.;
RT   "Genome sequence of Staphylococcus aureus strain Newman and comparative
RT   analysis of staphylococcal genomes: polymorphism and evolution of two major
RT   pathogenicity islands.";
RL   J. Bacteriol. 190:300-310(2008).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- CAUTION: In strains Mu3, Mu50, N315 and Newman, ebh is divided into two
CC       ORFs, ebhA and ebhB, which correspond to the C-terminal and N-terminal
CC       parts of the full gene, respectively. {ECO:0000305}.
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DR   EMBL; AP009351; BAF67616.1; -; Genomic_DNA.
DR   SMR; A6QGY4; -.
DR   EnsemblBacteria; BAF67616; BAF67616; NWMN_1344.
DR   KEGG; sae:NWMN_1344; -.
DR   HOGENOM; CLU_000041_2_1_9; -.
DR   OMA; IQFEQRV; -.
DR   Proteomes; UP000006386; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR011439; DUF1542.
DR   InterPro; IPR020840; Extracell_matrix-bd_GA.
DR   InterPro; IPR002988; GA_module.
DR   InterPro; IPR009063; Ig/albumin-bd_sf.
DR   Pfam; PF07564; DUF1542; 8.
DR   Pfam; PF01468; GA; 11.
DR   SMART; SM00844; GA; 20.
DR   SUPFAM; SSF46997; SSF46997; 39.
PE   4: Predicted;
KW   Cell membrane; Membrane; Repeat; Transmembrane; Transmembrane helix.
FT   CHAIN           1..3462
FT                   /note="Extracellular matrix-binding protein EbhA"
FT                   /id="PRO_0000345974"
FT   TRANSMEM        3267..3289
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          24..82
FT                   /note="FIVAR 1"
FT   DOMAIN          150..208
FT                   /note="FIVAR 2"
FT   DOMAIN          276..334
FT                   /note="FIVAR 3"
FT   DOMAIN          402..460
FT                   /note="FIVAR 4"
FT   DOMAIN          528..586
FT                   /note="FIVAR 5"
FT   DOMAIN          654..712
FT                   /note="FIVAR 6"
FT   DOMAIN          780..838
FT                   /note="FIVAR 7"
FT   DOMAIN          906..964
FT                   /note="FIVAR 8"
FT   DOMAIN          1032..1093
FT                   /note="FIVAR 9"
FT   DOMAIN          1158..1216
FT                   /note="FIVAR 10"
FT   DOMAIN          1284..1342
FT                   /note="FIVAR 11"
FT   DOMAIN          1410..1467
FT                   /note="FIVAR 12"
FT   DOMAIN          1535..1593
FT                   /note="FIVAR 13"
FT   DOMAIN          1661..1719
FT                   /note="FIVAR 14"
FT   DOMAIN          1787..1845
FT                   /note="FIVAR 15"
FT   DOMAIN          1913..1971
FT                   /note="FIVAR 16"
FT   DOMAIN          2039..2093
FT                   /note="FIVAR 17"
FT   DOMAIN          2161..2220
FT                   /note="FIVAR 18"
FT   DOMAIN          2415..2471
FT                   /note="FIVAR 19"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3365..3462
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..19
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3365..3443
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3444..3462
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   3462 AA;  378166 MW;  98A174D914AE2B58 CRC64;
     MVQQSTTVAE AQGNEQKANN VDAAMDKLRQ SIADNATTKQ NQNYTDASQN KKDAYNNAVT
     TAQGIIDQTT SPTLDPTVIN QAAGQVSTTK NALNGNENLE AAKQQASQSL GSLDNLNNAQ
     KQTVTDQING AHTVDEANQI KQNAQNLNTA MGNLKQAIAD KDATKATVNF TDADQAKQQA
     YNTAVTNAEN IISKANGGNA TQAEVEQAIK QVNAAKQALN GNANVQHAKD EATALINSSN
     DLNQAQKDAL KQQVQNATTV AGVNNVKQTA QELNNAMTQL KQGIADKEQT KADGNFVNAD
     PDKQNAYNQA VAKAEALISA TPDVVVTPSE ITAALNKVTQ AKNDLNGNTN LATAKQNVQH
     AIDQLPNLNQ AQRDEYSKQI TQATLVPNVN AIQQAATTLN DAMTQLKQGI ANKAQIKGSE
     NYHDADTDKQ TAYDNAVTKA EELLKQTTNP TMDPNTIQQA LTKVNDTNQA LNGNQKLADA
     KQDAKTTLGT LDHLNDAQKQ ALTTQVEQAP DIATVNNVKQ NAQNLNNAMT NLNNALQDKT
     ETLNSINFTD ADQAKKDAYT NAVSHAEGIL SKANGSNASQ TEVEQAMQRV NEAKQALNGN
     DNVQRAKDAA KQVITNANDL NQAQKDALKQ QVDAAQTVAN VNTIKQTAQD LNQAMTQLKQ
     GIADKDQTKA SGNFVNADTD KQNAYNNAVA HAEQIISGTP NANVDPQQVA QALQQVNQAK
     GDLNGNHNLQ VAKDNANTAI DQLPNLNQPQ KTALKDQVSH AELVTGVNAI KQNADALNNA
     MGTLKQQIQA NSQVPQSVDF TQADQDKQQA YNNAANQAQQ IANGIPTPVL TPDTVTQAVT
     TMNQAKDALN GDEKLAQAKQ EALANLDTLR DLNQPQRDAL RNQINQAQAL ATVEQTKQNA
     QNVNTAMSNL KQGIANKDTV KASENYHDAD ADKQTAYTNA VSQAEGIINQ TTNPTLNPDE
     ITRALTQVTD AKNGLNGEAK LATEKQNAKD AVSGMTHLND AQKQALKGQI DQSPEIATVN
     QVKQTATSLD QAMDQLSQAI NDKAQTLADG NYLNADPDKQ NAYKQAVAKA EALLNKQSGT
     NEVQAQVESI TNEVNAAKQA LNGNDNLANA KQQAKQQLAN LTHLNDAQKQ SFESQITQAP
     LVTDVTTINQ KAQTLDHAME LLRNSVADNQ TTLASEDYHD ATAQRQNDYN QAVTAANNII
     NQTTSPTMNP DDVNGATTQV NNTKVALDGD ENLAAAKQQA NNRLDQLDHL NNAQKQQLQS
     QITQSSDIAA VNGHKQTAES LNTAMGNLIN AIADHQAVEQ RGNFINADTD KQTAYNTAVN
     EAAAMINKQT GQNANQTEVE QAITKVQTTL QALNGDHNLQ VAKTNATQAI DALTSLNDPQ
     KTALKDQVTA ATLVTAVHQI EQNANTLNQA MHGLRQSIQD NAATKANSKY INEDQPEQQN
     YDQAVQAANN IINEQTATLD NNAINQAATT VNTTKAALHG DVKLQNDKDH AKQTVSQLAH
     LNNAQKHMED TLIDSETTRT AVKQDLTEAQ ALDQLMDALQ QSIADKDATR ASSAYVNAEP
     NKKQSYDEAV QNAESIIAGL NNPTINKGNV SSATQAVISS KNALDGVERL AQDKQTAGNS
     LNHLDQLTPA QQQALENQIN NATTRGEVAQ KLTEAQALNQ AMEALRNSIQ DQQQTEAGSK
     FINEDKPQKD AYQAAVQNAK DLINQTNNPT LDKAQVEQLT QAVNQAKDNL HGDQKLADDK
     QHAVTDLNQL NGLNNPQRQA LESQINNAAT RGEVAQKLAE AKALDQAMQA LRNSIQDQQQ
     TESGSKFINE DKPQKDAYQA AVQNAKDLIN QTGNPTLDKS QVEQLTQAVT TAKDNLHGDQ
     KLARDQQQAV TTVNALPNLN HAQQQALTDA INAAPTRTEV AQHVQTATEL DHAMETLKNK
     VDQVNTDKAQ PNYTEASTDK KEAVDQALQA AESITDPTNG SNANKDAVDQ VLTKLQEKEN
     ELNGNERVAE AKTQAKQTID QLTHLNADQI ATAKQNIDQA TKLQPIAELV DQATQLNQSM
     DQLQQAVNEH ANVEQTVDYT QADSDKQNAY KQAIADAENV LKQNANKQQV DQALQNILNA
     KQALNGDERV ALAKTNGKHD IDQLNALNNA QQDGFKGRID QSNDLNQIQQ IVDEAKALNR
     AMDQLSQEIT DNEGRTKGST NYVNADTQVK QVYDETVDKA KQALDKSTGQ NLTAKQVIKL
     NDAVTAAKKA LNGEERLNNR KAEALQRLDQ LTHLNNAQRQ LAIQQINNAE TLNKASRAIN
     RATKLDNAMG AVQQYIDEQH LGVISSTNYI NADDNLKANY DNAIANAAHE LDKVQGNAIA
     KAEAEQLKQN IIDAQNALNG DQNLANAKDK ANAFVNSLNG LNQQQQDLAH KAINNADTVS
     DVTDIVNNQI DLNDAMETLK HLVDNEIPNA EQTVNYQNAD DNAKTNFDDA KRLANTLLNS
     DNTNVNDING AIQAVNDAIH NLNGDQRLQD AKDKAIQSIN QALANKLKEI EASNATDQDK
     LIAKNKAEEL ANSIINNINK ATSNQAVSQV QTAGNHAIEQ VHANEIPKAK IDANKDVDKQ
     VQALIDEIDR NPNLTDKEKQ ALKDRINQIL QQGHNGINNA MTKEEIEQAK AQLAQALQDI
     KDLVKAKEDA KQDVDKQVQA LIDEIDQNPN LTDKEKQALK DRINQILQQG HNDINNAMTK
     EAIEQAKERL AQALQDIKDL VKAKEDAKND IDKRVQALID EIDQNPNLTD KEKQALKDRI
     NQILQQGHND INNALTKEEI EQAKAQLAQA LQDIKDLVKA KEDAKNAIKA LANAKRDQIN
     SNPDLTPEQK AKALKEIDEA EKRALQNVEN AQTIDQLNRG LNLGLDDIRN THVWEVDEQP
     AVNEIFEATP EQILVNGELI VHRDDIITEQ DILAHINLID QLSAEVIDTP STATISDSLT
     AKVEVTLLDG SKVIVNVPVK VVEKELSVVK QQAIESIENA AQQKINEINN SVTLTLEQKE
     AAIAEVNKLK QQAIDHVNNA PDVHSVEEIQ QQEQAHIEQF NPEQFTIEQA KSNAIKSIED
     AIQHMIDEIK ARTDLTDKEK QEAIAKLNQL KEQAIQAIQR AQSIDEISEQ LEQFKAQMKA
     ANPTAKELAK RKQEAISRIK DFSNEKINSI RNSEIGTADE KQAAMNQINE IVLETIRDIN
     NAHTLQQVEA ALNNGIARIS AVQIVTSDRA KQSSSTGNES NSHLTIGYGT ANHPFNSSTI
     GHKKKLDEDD DIDPLHMRHF SNNFGNVIKN AIGVVGISGL LASFWFFIAK RRRKEDEEEE
     LEIRDNNKDS IKETLDDTKH LPLLFAKRRR KEDEEDVTVE EKDSLNNGES LDKVKHTPFF
     LPKRRRKEDE EDVEVTNENT DEKVLKDNEH SPLLFAKRRK DKEEDVETTT SIESKDEDVP
     LLLAKKKNQK DNQSKDKKSA SKNTSKKVAA KKKKKKAKKN KK