ID   EBHA_STAAN              Reviewed;        6713 AA.
AC   Q99U54;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 111.
DE   RecName: Full=Extracellular matrix-binding protein EbhA;
DE   AltName: Full=ECM-binding protein homolog A;
GN   Name=ebhA; OrderedLocusNames=SA1267;
OS   Staphylococcus aureus (strain N315).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=158879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=N315;
RX   PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA   Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA   Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA   Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA   Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL   Lancet 357:1225-1240(2001).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- CAUTION: In strains Mu3, Mu50, N315 and Newman, ebh is divided into two
CC       ORFs, ebhA and ebhB, which correspond to the C-terminal and N-terminal
CC       parts of the full gene, respectively. {ECO:0000305}.
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DR   EMBL; BA000018; BAB42527.1; -; Genomic_DNA.
DR   PIR; B89921; B89921.
DR   SMR; Q99U54; -.
DR   EnsemblBacteria; BAB42527; BAB42527; BAB42527.
DR   KEGG; sau:SA1267; -.
DR   HOGENOM; CLU_000041_0_0_9; -.
DR   OMA; GNWSIDL; -.
DR   Proteomes; UP000000751; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR011439; DUF1542.
DR   InterPro; IPR020840; Extracell_matrix-bd_GA.
DR   InterPro; IPR002988; GA_module.
DR   InterPro; IPR009063; Ig/albumin-bd_sf.
DR   Pfam; PF07564; DUF1542; 8.
DR   Pfam; PF01468; GA; 19.
DR   SMART; SM00844; GA; 46.
DR   SUPFAM; SSF46997; SSF46997; 91.
PE   4: Predicted;
KW   Cell membrane; Membrane; Repeat; Transmembrane; Transmembrane helix.
FT   CHAIN           1..6713
FT                   /note="Extracellular matrix-binding protein EbhA"
FT                   /id="PRO_0000345978"
FT   TRANSMEM        6518..6540
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          1..58
FT                   /note="FIVAR 1"
FT   DOMAIN          126..184
FT                   /note="FIVAR 2"
FT   DOMAIN          252..310
FT                   /note="FIVAR 3"
FT   DOMAIN          378..436
FT                   /note="FIVAR 4"
FT   DOMAIN          504..562
FT                   /note="FIVAR 5"
FT   DOMAIN          630..688
FT                   /note="FIVAR 6"
FT   DOMAIN          756..814
FT                   /note="FIVAR 7"
FT   DOMAIN          882..940
FT                   /note="FIVAR 8"
FT   DOMAIN          1008..1066
FT                   /note="FIVAR 9"
FT   DOMAIN          1134..1192
FT                   /note="FIVAR 10"
FT   DOMAIN          1260..1318
FT                   /note="FIVAR 11"
FT   DOMAIN          1386..1444
FT                   /note="FIVAR 12"
FT   DOMAIN          1512..1570
FT                   /note="FIVAR 13"
FT   DOMAIN          1638..1696
FT                   /note="FIVAR 14"
FT   DOMAIN          1764..1822
FT                   /note="FIVAR 15"
FT   DOMAIN          1890..1948
FT                   /note="FIVAR 16"
FT   DOMAIN          2142..2200
FT                   /note="FIVAR 17"
FT   DOMAIN          2268..2325
FT                   /note="FIVAR 18"
FT   DOMAIN          2393..2451
FT                   /note="FIVAR 19"
FT   DOMAIN          2519..2577
FT                   /note="FIVAR 20"
FT   DOMAIN          2645..2703
FT                   /note="FIVAR 21"
FT   DOMAIN          2771..2829
FT                   /note="FIVAR 22"
FT   DOMAIN          2897..2955
FT                   /note="FIVAR 23"
FT   DOMAIN          3023..3081
FT                   /note="FIVAR 24"
FT   DOMAIN          3149..3207
FT                   /note="FIVAR 25"
FT   DOMAIN          3275..3333
FT                   /note="FIVAR 26"
FT   DOMAIN          3401..3459
FT                   /note="FIVAR 27"
FT   DOMAIN          3527..3585
FT                   /note="FIVAR 28"
FT   DOMAIN          3653..3711
FT                   /note="FIVAR 29"
FT   DOMAIN          3779..3837
FT                   /note="FIVAR 30"
FT   DOMAIN          3905..3963
FT                   /note="FIVAR 31"
FT   DOMAIN          4031..4089
FT                   /note="FIVAR 32"
FT   DOMAIN          4157..4218
FT                   /note="FIVAR 33"
FT   DOMAIN          4283..4341
FT                   /note="FIVAR 34"
FT   DOMAIN          4409..4467
FT                   /note="FIVAR 35"
FT   DOMAIN          4535..4592
FT                   /note="FIVAR 36"
FT   DOMAIN          4660..4718
FT                   /note="FIVAR 37"
FT   DOMAIN          4786..4844
FT                   /note="FIVAR 38"
FT   DOMAIN          4912..4970
FT                   /note="FIVAR 39"
FT   DOMAIN          5038..5096
FT                   /note="FIVAR 40"
FT   DOMAIN          5164..5222
FT                   /note="FIVAR 41"
FT   DOMAIN          5290..5344
FT                   /note="FIVAR 42"
FT   DOMAIN          5412..5471
FT                   /note="FIVAR 43"
FT   DOMAIN          5666..5722
FT                   /note="FIVAR 44"
FT   REGION          3159..3178
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          6616..6713
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        6616..6694
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        6695..6713
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   6713 AA;  722343 MW;  AF6EEDE226BE4888 CRC64;
     MGNLQTAIND KSGTLASQNF LDADEQKRNA YNQAISAAET ILNKQTGPNT AKTAVEQALN
     NVNSAKHALN GTQNLNNAKQ AAITAINGAS DLNQKQKDAL KAQANGAQRV SNANDVQRNA
     TELNTAMGQL QHAIADKTNT LASSKYVNAD STKQNAYTTK VTNAEHIISG TPTVVTTPSE
     VTAAANQVNS AKQELNGDER LRVAKQNANT AIDALTQLNT PQKAKLKEQV GQANRLEDVQ
     SVQTNGQSLN NAMKGLRDSI ANETTVKASQ NYTDASPNNQ STYNSAVSNA KGIINQTNNP
     TMDTSAITQA TTQVNNAKNG LNGAENLRNA QNTAKQNLNT LSHLTNNQKS AISSQIDRAG
     HVSEVTAAKN AATELNAQMG NLEQAIHDQN TVKQGVNFTD ADKAKRDAYT NAVSRAETIL
     NKTQGANTSK QDVEAAIQNV TSAKNALNGD QNVTNAKNAA KNALNNLTSI NNAQKRDLTT
     KIDQATTVAG VEAVSNTGTQ LNTAMANLQN GINDKANTLA SENYHDADSD KKTAYTQAVT
     NAENILNKNS GSNLDKAAVE NALSQVTNAK GALNGNHNLE QAKSNANTTI NGLQHLTTAQ
     KDKLKQQVQQ AQNVAGVDTV KSSANTLNGA MGTLRNSIQD NTATKNGQNY LDATERNKTN
     YNNAVDSANG VINATSNPNM DANAINQIAT QVTSTKNALD GTHNLTQAKQ TATNAIDGAT
     NLNKAQKDAL KAQVTSAQRV ANVTSIQQTA NELNTAMGQL QHGIDDENAT KQTQKYRDAE
     QSKKTAYDQA VAAAKAILNK QTGSNSDKAA VDRALQQVTS TKDALNGDAK LAEAKAAARQ
     NLGTLNHITN AQRTALEGQI NQATTVDGVN TVKTNANTLD GAMNSLQGAI NDKDATLRNQ
     NYLDADESKR NAYTQAVTAA EGILNKQTGG NTSKADVDNA LNAVTRAKAA LNGAENLRNA
     KTSATNTING LPNLTQLQKD NLKHQVEQAQ NVVGVNGVKD KGNTLNTAMG ALRTSIQNDN
     TTKTSQNYLD ASDSNKNNYN TAVNNANGVI NATNNPNMDA NAINDMANQV NTTKAALNGA
     QNLAQAKTNA TNTINNAQDL NQKQKDALKT QVNNAQRVSD ANNVQHTATE LNGAMTALKA
     AIADKERTKA SGNYVNADQE KRQAYDSKVT NAENIINGTP NATLTVNDVN SAASQVNAAK
     TALNGDNNLR VAKEHANNTI DGLAQLNNVQ KAKLKEQVQS ATTLDGVQTV KNSSQTLNTA
     MKGLRDSIAN EATIKAGQNY TDASPNNRNE YDSAVTAAKA IINQTSNPTM EPNTITQATS
     QVTTKEHALN GAQNLAQAKT TAKNNLNNLT SINNAQKDAL TRNIDGATTV AGVNQETAKA
     TELNNAMHSL QNGINDETQT KQTQKYLDAE PSKKSAYDQA VNAAKAILTK ASGQNVDKAA
     VEQALQNVNS TKTALNGDAK LNEAKAAAKQ TLGTLTHINN AQRNALDNEI TQATNVEGVN
     TVKAKAQQLD GAMGQLETSI RDKDTTLQSQ NYQDADDAKR TAYSQAVNAA ATILNKTAGG
     NTPKADVERA MQAVTQANTA LNGIQNLERA KQAANTAITN ASDLNTKQKE ALKAQVTSAG
     RVSAANGVEH TATELNTAMT ALKRAIADKA DTKASGNYVN ADANKRQAYD EKVTAAEHIV
     SGTPTPTLTP SDVTNAATQV TNAKTQLNGN HNLEVAKQNA NTAIDGLTSL NGPQKAKLKE
     QVGQATTLPN VQTVRDNAQT LNTAMKGLRD SIANEATIKA GQNYTDASQN KQNDYNNAVT
     AAKAIIGQTT SPSMIAQEIN QAKDQVTAKQ QALNGQENLR TAQTNAKQHL NGLSDLTNAQ
     KDAAKRQIEG ATHVNEVTQA QNNADALNTA MTNLKNGIQD QNTIKQGVNF TDADEAKRNA
     YTNAVTQAEQ ILNKAQGPNT AKDGVETALQ NVQRAKNELN GNQNVANAKT TAKNALNNLT
     SINNAQKAAL KSQIEGATTV AGVNQVSTMA SELNTAMSNL QRGINDEAAT KAAQKYTEAD
     RDKQTAYNDA VTAAKTLLDK TAGSNDNKVA VEQALQRVNT AKTALNGDAR LNEAKNTAKQ
     QLATMSHLTN AQKANLTEQI ERGTTVAGVQ GIQANAGTLN QAMNQLRQSI ASKDATKSSE
     DYQDANADLQ NAYNDAVTNA EGIISATNNP EMNPDTINQK ASQVNSAKSA LNGDEKLAAA
     KQTAKSDIGR LTDLNNAQRT AANAEVDQAP NLAAVTAAKN KATSLNTAMG NLKHALAEKD
     NTKRSVNYTD ADQPKQQAYD TAVTQAEAIT NANGSNANET QVQAALNQLN QAKNDLNGDN
     KVAQAKETAK RALASYSNLN NAQSTAATSQ IDNATTVADV TAAQNTANEL NTAMGQLQNG
     INDQNTVKQQ VNFTDADQGK KDAYTNAVTN AQGILDKANG QNMTKAQVEA ALNQVTTAKN
     ALNGDANVRQ AKSDAKANLG TLTHLNNAQK QDLTSQIEGA TTVNGVNSVK TKAQDLDGAM
     QRLESAIANK DQTKASENYI DADPTKKTAF DNAITQAESY LNKDHGTNKD KQAVEQAIQS
     VTSTENALNG DANLQCAKTE ATQAIDNLTQ LNTPQKTALK QQVNAAQRVS GVTDLKNSAT
     SLNNAMDQLK QAIGDHDTIV AGGNYTNASP DKQGAYTDAY NAAKNIVNGS PNVITNAADV
     TAATQRVNNA ETSLNGDTNL ATAKQQAKDA LRQMTHLSDA QKQSITGQID SATQVTGVQS
     VKDNATNLDN AMNQLRNSIA NKDEVKASQP YVDADTDKQN AYNTAVTSAE NIINATSQPT
     LDPSAVTQAA NQVNTNKTAL NGAQNLANKK QETTANINRL SHLNNAQKQD LNTQVTNAPN
     ISTVNQVKTK AEQLDQAMER LINGIQDKDQ VKQSVNFTDA DPEKQTAYNN AVTAAENIIN
     QANGTNANQS QVEAALSTVT TTKQALNGDR KVTDAKNNAN QTLSTLDNLN NAQKGAVTGN
     INQAHTVAEV TQAIQTAQEL NTAMGNLKNS LNDKDTTLGS QNFADADPEK KNAYNEAVRN
     AENILNKSTG TNVPKDQVEA AMNQVNTTKA ALNGTQNLEK AKQHANTAID GLSHLTNAQK
     EALKQLVQQS TTVAEAQGNE QKANNVDAAM DKLRQSIADN ATTKQNQNYT DASPNKKDAY
     NNAVTTAQGI IDQTTNPSLD PTVINQAAGQ VSTSKNALNG NENLEAAKQQ ATQSLGSLDN
     LNNAQKQAVT NQINGAHTVD EANQIKQNAQ NLNTAMGNLK QAIADKDATK ATVNFTDADQ
     AKQQAYNTAV TNAENIISKA NGGNATQTEV EQAIQQVNAA KQALNGNANV QHAKDEATAL
     INNSNDLNQA QKDALKQQVQ NATTVAGVNN VKQTAQELNN AMTQLKQGIA DKEQTKADGN
     FVNADSDKQN AYNQAVAKAE ALISGTPDVV VTPSEITAAL NKVTQAKNDL NGNTNLATAK
     QNVQHAIDQL PNLNQAQRDE YSKQITQATL VPNVNAIQQA ATTLNDAMTQ LKQGIANKAQ
     IKGSENYHDA DTDKQTAYDN AVTKAEELLK QTTNPTMDPN TIQQALTKVN DTNQALNGNQ
     KLADAKQDAK TTLGTLDHLN DAQKQALTTQ VEQAPDIATV NNVKQNAQNL NNAMTNLNNA
     LQDKTETLNS INFTDADQAK KDDYTNAVSH AEGILSKANG SNASQTEVEQ AMQRVNEAKQ
     ALNGNDNVQR AKDAAKQVIT NANDLNQAQK DALKQQVDAA QTVANVNTIK QTAQDLNQAM
     TQLKQGIADK DQTKANGNFV NADTDKQNAY NNAVAHAEQI ISGTPNANVD PQQVAQALQQ
     VNQAKGDLNG NHNLQVAKDN ANTAIDQLPN LNQPQKTALK DQVSHAELVT GVNAIKQNAD
     ALNNAMGTLK QQIQANSQVP QSVDFTQADQ DKQQAYNNAA NQAQQIANGT PTPVLAPDTV
     TKAVTTMNQA KDALNGDEKL AQAKQDALAN LDTLRDLNQP QRDALRNQIN QAQALATVEQ
     TKQNAQNVNT AMGNLKQGIA NKDTVKASEN YHDADVDKQT AYTNAVSQAE GIINQTTNPT
     LNPDDITRAL TQVTDAKNSL NGEAKLATEK QNAKDAVSGM THLNDAQKQA LKGQIDQSPE
     IATVNQVKQT ATSLDQAMDQ LSQAINDKDQ ILADGNYLNA DPDKQNAYKQ AVAKAEALLN
     KQSGTNEVQA QVESITNEVN AAKQALNGND NLANAKQQAK QQLANLTHLN DAQKQSFESQ
     ITQAPLVTDV TTINQKAQTL DHAMELLRNS VADNQTTLAS EDYHDATAQR QNDYNKAVTA
     ANNIINQTTS PTMNPDDVNG ATTQVNNTKV ALDGDENLAA AKQQANNRLD QLDHLNNAQK
     QQLQSQITQS SDIAAVNGHK QTAESLNTAM GNLINAIADH QAVEQRGNFI NADTDKQTAY
     NTAVNEAAAM INKQTGQNAN QTEVEQAITK VQTTLQALNG DHNLQVAKTN ATQAIDVLTS
     LNDPQKTALK DQVTAATLVT AVHQIEQNAN TLNQAMHGLR QSIQDNAATK ANSKYINEDQ
     PEQQNYDQAV QAANNIINEQ TATLDNNAIN QVAATVNTTK AALHGDVKLQ NDKDHAKQTV
     SQLAHLNNAQ KHMEDTLIDS ETTRTAVKQD LTEVQALDQL MDALQQSIAD KDATRASSAY
     VNAEPNKKQA YDEAVQNAES IIAGLNNPTI NKGNVSSATQ AVISSKNALD GVERLAQDKQ
     TAGNSLNHLD QLTPAQQQAL ENQINNATTR DKVAEIIAQA QALNEAMKAL KESIKDQPQT
     EASSKFINED QAQKDAYTQA VQHAKDLINK TTDPTLAKSI IDQATQAVTD AKNNLHGDQK
     LAQDKQRATE TLNNLSNLNT PQRQALENQI NNAATRGEVA QKLTEAQALN QAMEALRNSI
     QDQQQTESGS KFINEDKPQK DAYQAAVQNA KDLINQTGNP TLDKAQVEQL THAFKQAKDN
     LHGDQKLADD KQHAVTDLNQ LNGLNNPQRQ ALESQINNAA TRGEVAQKLA EAKALDQAMQ
     ALRNSIQDQQ QTEAGSKFIN EDKPQKDAYQ AAVQNAKDLI NQTGNPTLDK SQVEQLTQAV
     TTAKDNLHGD QKLARDQQQA VTTVNALPNL NHAQQQTLTD AINAAPTRTE VAQHVQTATE
     LDHAMETLKN KVDQVNTDKA QPNYTEASTD KKEAVDQALQ AAQSITDPTN GSNANKDAVE
     QALTKLQEKV NELNGNERVA EAKTQAKQTI DQLTHLNADQ IATAKQNIDQ ATKLQPIAEL
     VDQATQLNQS MDQLQQAVNE HANVEQTIDY TQADSDKQKA YKQAIADAEN VLKQNANKQQ
     VDQALQNILN AKQALNGDER VALAKTNGKH DIDQLNALNN AQQDGFKGRI DQSNDLNQIQ
     QIVDEAKALN RAMDQLSQEI TGNEGRTKGS TNYVNADTQV KQVYDEAVDK AKQALDKSSG
     QNLTAEQVIK LNDAVTAAKK ALNGEERLNN RKAEALQRLD QLTHLNNAQR QLAIQQINNA
     ETLNKASRAI NRATKLDNAM GAVQQYIDEQ HLGVISSTNY INADDNLKAN YDNAIANAAH
     ELDKVQGNAI AKAEAEQLKQ NIIDAQNALN GDQNLANAKD KANAFVNSLN GLNQQQQDLA
     HKAINNADTV SDVTDIVNNQ IDLNDAMETL KHLVDNEIPN AEQTVNYQNA DDNAKTNFDD
     AKRLANTLLN SDNTNVNDIN GAIQAVNDAI HNLNGDQRLQ DAKDKAIQSI NQALANKLKE
     IEASNATDQD KLIAKNKAEE LANSIINNIN KATSNQAVSQ VQTAGNHAIE QVHANEIPKA
     KIDANKDVDK QVQALIDEID RNPNLTDKEK QALKDRINQI LQQGHNDINN ALTKEEIEQA
     KAQLAQALQD IKDLVKAKED AKQDVDKQVQ ALIDEIDQNP NLTDKEKQAL KDRINQILQQ
     GHNGINNAMT KEEIEQAKAQ LAQALKEIKD LVKAKENAKQ DVDKQVQALI DEIDQNPNLT
     DKEKQALKDR INQILQQGHN DINNAMTKEE IEQAKAQLAQ ALQDIKDLVK AKEDAKNAIK
     ALANAKRDQI NSNPDLTPEQ KAKALKEIDE AEKRALQNVE NAQTIDQLNR GLNLGLDDIR
     NTHVWEVDEQ PAVNEIFEAT PEQILVNGEL IVHRDDIITE QDILAHINLI DQLSAEVIDT
     PSTATISDSL TAKVEVTLLD GSKVIVNVPV KVVEKELSVV KQQAIESIEN AAQQKIDEIN
     NSVTLTLEQK EAAIAEVNKL KQQAIDHVNN APDVHSVEEI QQQEQAYIEQ FNPEQFTIEQ
     AKSNAIKSIE DAIQHMIDEI KARTDLTDKE KQEAIAKLNQ LKEQAIQAIQ RAQSISEITE
     QLEQFKAQMK AANPTAKELA KRKQEAISRI KDFSNEKINS IRNSEIGTAD EKQAAMNQIN
     EIVLETIRDI NNAHTLQQVE AALNNGIARI SAVQIVISDR AKQSSSTGNE SNSHLTIGYG
     TANHPFNSST IGHKKKLDED DDIDPLHMRH FSNNFGNVIK NAIGVVGISG LLASFWFFIA
     KRRRKEDEEE ELEIRDNNKD SIKETLDDTK HLPLLFAKRR RKEDEEDVTV EEKDSLNNGE
     SLDKVKHTPF FLPKRRRKED EEDVEVTNEN TDEKVLKDNE HSPLLFAKRR KDKEEDVETT
     TSIESKDEDV PLLLAKKKNQ KDNQSKDKKS ASKNTSKKVA AKKKKKKSKK NKK