ID   EBHB_STAA1              Reviewed;        3890 AA.
AC   A7X2C5;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Extracellular matrix-binding protein EbhB;
DE   AltName: Full=ECM-binding protein homolog B;
DE   Flags: Precursor;
GN   Name=ebhB; OrderedLocusNames=SAHV_1423;
OS   Staphylococcus aureus (strain Mu3 / ATCC 700698).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=418127;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mu3 / ATCC 700698;
RX   PubMed=17954695; DOI=10.1128/aac.00534-07;
RA   Neoh H.-M., Cui L., Yuzawa H., Takeuchi F., Matsuo M., Hiramatsu K.;
RT   "Mutated response regulator graR is responsible for phenotypic conversion
RT   of Staphylococcus aureus from heterogeneous vancomycin-intermediate
RT   resistance to vancomycin-intermediate resistance.";
RL   Antimicrob. Agents Chemother. 52:45-53(2008).
CC   -!- CAUTION: In strains Mu3, Mu50, N315 and Newman, ebh is divided into two
CC       ORFs, ebhA and ebhB, which correspond to the C-terminal and N-terminal
CC       parts of the full gene, respectively. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AP009324; BAF78306.1; -; Genomic_DNA.
DR   SMR; A7X2C5; -.
DR   KEGG; saw:SAHV_1423; -.
DR   HOGENOM; CLU_000047_2_0_9; -.
DR   OMA; LRCDNDS; -.
DR   InterPro; IPR044024; aRib.
DR   InterPro; IPR026361; Ebh_dom.
DR   InterPro; IPR020840; Extracell_matrix-bd_GA.
DR   InterPro; IPR002988; GA_module.
DR   InterPro; IPR009063; Ig/albumin-bd_sf.
DR   InterPro; IPR005877; YSIRK_signal_dom.
DR   Pfam; PF18938; aRib; 1.
DR   Pfam; PF01468; GA; 2.
DR   Pfam; PF04650; YSIRK_signal; 1.
DR   SMART; SM00844; GA; 7.
DR   SUPFAM; SSF46997; SSF46997; 12.
DR   TIGRFAMs; TIGR04264; hyperosmo_Ebh; 1.
DR   TIGRFAMs; TIGR01168; YSIRK_signal; 1.
PE   3: Inferred from homology;
KW   Repeat; Signal.
FT   SIGNAL          1..39
FT                   /evidence="ECO:0000255"
FT   CHAIN           40..3890
FT                   /note="Extracellular matrix-binding protein EbhB"
FT                   /id="PRO_0000345970"
FT   DOMAIN          2524..2580
FT                   /note="FIVAR 1"
FT   DOMAIN          2610..2666
FT                   /note="FIVAR 2"
FT   DOMAIN          2687..2750
FT                   /note="FIVAR 3"
FT   DOMAIN          2780..2836
FT                   /note="FIVAR 4"
FT   DOMAIN          2864..2919
FT                   /note="FIVAR 5"
FT   DOMAIN          2947..3002
FT                   /note="FIVAR 6"
FT   DOMAIN          3030..3085
FT                   /note="FIVAR 7"
FT   DOMAIN          3154..3212
FT                   /note="FIVAR 8"
FT   DOMAIN          3280..3339
FT                   /note="FIVAR 9"
FT   DOMAIN          3407..3465
FT                   /note="FIVAR 10"
FT   DOMAIN          3533..3591
FT                   /note="FIVAR 11"
FT   DOMAIN          3659..3717
FT                   /note="FIVAR 12"
FT   DOMAIN          3785..3843
FT                   /note="FIVAR 13"
FT   REGION          41..152
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          249..277
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1347..1372
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2418..2438
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        41..125
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        126..141
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   3890 AA;  420628 MW;  593A6FEA79DCE2B7 CRC64;
     MNYRDKIQKF SIRKYTVGTF STVIATLVFL GFNTSQAHAA ETNQPASVVK QKQQSNNEQT
     ENRESQVQNS QNSQNSQSLS ATHENEQPNN SQANLVNQKV AQSSTTNDEQ PASQNVNTKK
     DSATAATTQP DKEESKHKQN ESQSANKNGN DNRAAHVENH EANVVTASDS SDNGNVQHDR
     NELQAFFDAN YHDYRFIDRE NADSGTFNYV KGIFDKINTL LGSNDPINNK DLQLAYKELE
     QAVALIRTMP QRQQTSRRSN RIQTRSVESR AAEPRSVSDY QNANSSYYVE NANDGSGYPV
     GTYINASSKG APYNLPTTPW NTLKASDSKE IALMTAKQTG DGYQWVIKFN KGHAPHQNMI
     FWFALPADQV PVGRTDFVTV NSDGTNVQWS HGAGAGANKP LQQMWEYGVN DPDRSHDFKI
     RNRSGQVIYS WPTVHVYSLE DLSRASDYFS EAGATPATKA FGRQNFEYIN GQKPAESPGV
     PKVYTFIGQG DASYTISFKT QGPTVNKLYY AAGGRALEYN QLFMYSQLYV ESTQDHQQRL
     NGLRQVVNRT YRIGTTKRVE VSQGNVQTKK VLESTNLNID DFVDDPLSYV KTPSNKVLGF
     YPTNANTNAF RPGGVQELNE YQLSQLFTDQ KLQEAARTRN PIRLMIGFDY PDGYGNSETL
     VPVNLTVLPE IQHNIKFFKN DDTQNIAEKP FSKQAGHPVF YVYAGNQGNA SVNLGGSVTS
     IQPLRINLTS NENFTDKDWQ ITGIPRTLHI ENSTNRTNNA RERNIELVGN LLPGDYFGTI
     RFGRKEQLFE IRVKPHTPTI TTTAEQLRGT ALQKVPVNIS GIPLDPSALV YLVAPTNQTT
     NGGSEADQIP SGYTILATGT PDGVHNTITI RPQDYVVFIP PVGKQIRAVV YYNKVVASNM
     SNAVTILPDD IPPTINNPVG INAKYYRGDE VNFTMGVSDR HSGIKNTTIT TLPSGWTSNL
     TKSDNKNGSL AITGRVSMNQ AFNSDITFKV SATDNVNNTT NDSQSKHVSI HVGKISEDAH
     PIVLGNTEKV VVVNPTAVSN DEKQSIITAF MNKNQNIRGY LASTDPVTVD NNGNVTLHYR
     DGSSTTLDAT NVMTYEPVVK SEYQTANAAK TATVTIAKGQ SFNIGDIKQY FTLSNGQAIP
     NGTFTNITSD RTIPTAQEVS QMNAGTQLYH IVASNAYHKD TEDFYISLKI VDVKQPEGDQ
     RVYRTSTYDL TTDEISKVKQ AFINANRDVI TLAEGDISVT NTPNGANVST ITVNINKGRL
     TKSFASNLAN MNFLRWVNFP QDYTVTWTNA KIANRPTDGG LSWSDDHKSL IYRYDATLGT
     QITTNDILTM LKATTTVPGL RNNITGNEKA QAEAGGRPNY RTTGYSQSNA TTDGQRQFTL
     NGQVIQILDI INPSNGYGGQ PVTNSNTRAN HSNSTVVNVN EPAANGAGAF TIDHVVKSNS
     THNASDAVYK AQLYLTPYGP KQYVEHLNQN TGNTTDAINI YFVPSDLVNP TISVGNYTNH
     QVFSGETFTN TITANDNFGV QSVTVPNTSQ ITGTVDNNHQ HVSATAPNVT SATSKTINLL
     ATDTSGNTAT TSFNVTVKPL RDKYRVGTSS TAANPVRIAN ISNNATVSQA DQTTIINSLT
     FTSNAPNRNY ATASANEITS KTVSNVSRTG NNANVTVTVT HQDGTTSTVT VPVKHVIPEI
     VAHSHYTVQG QDFPAGNGSS AADYFKLSNG SAIPDATITW VSGQAPNKDN TRIGEDITVT
     AHILIDGETT PITKTATYKV VRTVPKHVFE TARGVLYPGV SDMYDAKQYV KPVNNSWSTN
     AQHMNFQFVG TYGPNKDVVG ISTRLIRVTY DNRQTEDLTI LSKVKPDPPR IDANSVTYKA
     GLTNQEIKVN NVLNNSSVKL FKADNTPLNV TNITHGSGFS SVVTVSDALP NGGIKAKSSI
     SMNNVTYTTQ DEHGQVVTVT RNESVDSNDS ASVTVTPQLQ ATTEGAVFIK GGDGFDFGHV
     ERFIQNPPHG ATVAWHDSPD TWKNTVGNTH KTAVVTLPSG QGTRNVEVPV KVYPVANAKA
     PSRDVKGQNL THGTNAIDYI TFDPNTNTNG ITAAWANRQQ PNNQQAGVQH LNVDVTYPGI
     SAAKRVPVTV NVYQFEFPQT TYTTTVGGTL ASGTQASGYA HMQNASGLPT DGFTYKWNRD
     TTGTNDANWA AMNKPNTAQV VNAKYDVIYN GHTFATSLPA KFVVKDVQPA KPTVTETAAG
     AITIAPGANQ TVNTHAGNVT TYADKLVIKR NGNVVTTFTR RNNTSPWVKE ASADNVTGIV
     GTNNGITVAA GTFNPADTIQ VVATQGSGET ISDEQRSDDF TVVAPQPNQA TTKIWQNGHI
     DITPNNPSGH LINPTQAMDI AYTEKVGNGA EHSKTINVVR GQNNQWTIAN KPDYVTLDAQ
     TGKVTFNANT IKPNSSITIT PKAGTGHSVS SNPSTLTAPA AHTVNTTEIV KDYGSNVTAA
     EINNAVQVAN KRTATIKNGT AMPTNLAGGS TTTIPVTVTY NDGSTEEVQE SIFTKADKRE
     LITAKNHLDD PVSTEGKKPG TITQYNNAMH NAQQQINTAK TEAQQVINNE RATPQQVSDA
     LTKVRAAQTK IDQAKALLQN KEDNSQLVTS KNNLQSSVNQ VPSTAGMTQQ SIDNYNAKKR
     EAETEITAAQ RVIDNGDATA QQISDEKHRV DNALTALNQA KHDLTADTHA LEQAVQQLNR
     TGTTTGKKPA SITAYNNSIR ALQSDLTSAK NSANAIIQKP IRTVQEVQSA LTNVNRVNER
     LTQAINQLVP LADNSALRTA KTKLDEEINK SVTTDGMTQS SIQAYENAKR AGQTETTNAQ
     NVINNGDATD QQIAAEKTKV EEKYNSLKQA IAGLTPDLAP LQTAKTQLQN DIDQPTSTTG
     MTSASVAAFN DKLSAARTKI QEIDRVLASH PDVATIRQNV TAANAAKTAL DQARNGLTVD
     KAPLENAKNQ LQHSIDTQTS TTGMTQDSIN AYNAKLTAAR NKVQQINQVL AGSPTVDQIN
     TNTSAANQAK SDLDHARQAL TPDKAPLQNA KTQLEQSINQ PTDTTGMTTA SLNAYNQKLQ
     AARQKLTEIN QVLNGNPTVQ NINDKVAEAN QAKDQLNTAR QGLTLDRQPA LTTLHGASNL
     NQAQQNNFTQ QINAAQNHAA LETIKSNITA LNTAMTKLKD SVADNNTIKS GQNYTDATPA
     NKQAYDNAVN AAKGVIGETT NPTMDVNTVN QKAASVKSTK DALDGQQNLQ RAKTEATNAI
     THASDLNQAQ KNALTQQVNS AQNVQAVNDI KQTTQSLNTA MTGLKRGVAN HNQVVQSDNY
     VNADTNKKND YNNAYNHAND IINGNAQHPV ITPSDVNNAL SNVTSKEHAL NGEAKLNAAK
     QEANTALGHL NNLNNVQRQN LQSQINGAHQ IDAVNTIKQN ATNLNSAMGN LRQAVADKDQ
     VKRTEDYADA DTAKQNAYNS AVSSAETIIN QTANPTMSVD DVNRATSAVT TNKNALNGDE
     KLVQSKTDAA RAIDALPHLN NAQKADVKSK INAASNIAGV NTVKQQGTDL NTAMGNLQGA
     INDEQTTLNS QNYQDATPSK KTAYTNAVQA AKDILNKSNG QNKTKDQVTE AMNQVNSAKN
     NLDGTRLLDQ AKQTAKQQLN NMTHLTTAQK TNLTNQINSG TTVAGVHTVQ SNANTLDQAM
     NTLRQSIANN DATKASEDYV DANNDKQTAY NNAVAAAETI INANSNPEMN PSTITQKAEQ
     VNSSKTALNG DENLATAKQN AKTYLNTLTS ITDAQKNNLI SQISSATRVS GVDTVKQNAQ
     HLDQAMANLQ NGINNESQVK SSEKYRDADT NKQQEYDNAI TAAKAILNKS TGPNTAQNAV
     EAALQRVNTA KDALNGDAKL IAAQNAAKQH LGTLTHITTA QRNDLTNQIS