EBH_STAA8
ID EBH_STAA8 Reviewed; 9535 AA.
AC Q2FYJ6;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 1.
DT 25-MAY-2022, entry version 96.
DE RecName: Full=Extracellular matrix-binding protein ebh;
DE AltName: Full=ECM-binding protein homolog;
DE Flags: Precursor;
GN Name=ebh; OrderedLocusNames=SAOUHSC_01447;
OS Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=93061;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC 8325 / PS 47;
RA Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT "The Staphylococcus aureus NCTC 8325 genome.";
RL (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL D.C. (2006).
RN [2]
RP FUNCTION IN FIBRONECTIN BINDING, AND REPRESSION BY AGR.
RX PubMed=12438342; DOI=10.1128/iai.70.12.6680-6687.2002;
RA Clarke S.R., Harris L.G., Richards R.G., Foster S.J.;
RT "Analysis of ebh, a 1.1-megadalton cell wall-associated fibronectin-binding
RT protein of Staphylococcus aureus.";
RL Infect. Immun. 70:6680-6687(2002).
CC -!- FUNCTION: Promotes bacterial attachment to both soluble and immobilized
CC forms of fibronectin (Fn), in a dose-dependent and saturable manner.
CC {ECO:0000269|PubMed:12438342}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- INDUCTION: Expressed at the postexponential growth phase. Down-
CC regulated by agr. {ECO:0000269|PubMed:12438342}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000253; ABD30536.1; -; Genomic_DNA.
DR RefSeq; WP_001109324.1; NZ_LS483365.1.
DR RefSeq; YP_499969.1; NC_007795.1.
DR SMR; Q2FYJ6; -.
DR STRING; 93061.SAOUHSC_01447; -.
DR EnsemblBacteria; ABD30536; ABD30536; SAOUHSC_01447.
DR GeneID; 3920225; -.
DR KEGG; sao:SAOUHSC_01447; -.
DR PATRIC; fig|93061.5.peg.1320; -.
DR HOGENOM; CLU_222673_0_0_9; -.
DR OMA; NRATKEM; -.
DR Proteomes; UP000008816; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR044024; aRib.
DR InterPro; IPR011439; DUF1542.
DR InterPro; IPR026361; Ebh_dom.
DR InterPro; IPR020840; Extracell_matrix-bd_GA.
DR InterPro; IPR002988; GA_module.
DR InterPro; IPR009063; Ig/albumin-bd_sf.
DR InterPro; IPR005877; YSIRK_signal_dom.
DR Pfam; PF18938; aRib; 1.
DR Pfam; PF07564; DUF1542; 8.
DR Pfam; PF01468; GA; 20.
DR Pfam; PF04650; YSIRK_signal; 1.
DR SMART; SM00844; GA; 45.
DR SUPFAM; SSF46997; SSF46997; 86.
DR TIGRFAMs; TIGR04264; hyperosmo_Ebh; 1.
DR TIGRFAMs; TIGR01168; YSIRK_signal; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..39
FT /evidence="ECO:0000255"
FT CHAIN 40..9535
FT /note="Extracellular matrix-binding protein ebh"
FT /id="PRO_0000345972"
FT TRANSMEM 9341..9361
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 2524..2580
FT /note="FIVAR 1"
FT DOMAIN 2610..2666
FT /note="FIVAR 2"
FT DOMAIN 2687..2750
FT /note="FIVAR 3"
FT DOMAIN 2780..2836
FT /note="FIVAR 4"
FT DOMAIN 2864..2919
FT /note="FIVAR 5"
FT DOMAIN 2947..3002
FT /note="FIVAR 6"
FT DOMAIN 3030..3085
FT /note="FIVAR 7"
FT DOMAIN 3154..3212
FT /note="FIVAR 8"
FT DOMAIN 3280..3339
FT /note="FIVAR 9"
FT DOMAIN 3407..3465
FT /note="FIVAR 10"
FT DOMAIN 3533..3591
FT /note="FIVAR 11"
FT DOMAIN 3659..3717
FT /note="FIVAR 12"
FT DOMAIN 3785..3843
FT /note="FIVAR 13"
FT DOMAIN 3911..3969
FT /note="FIVAR 14"
FT DOMAIN 4037..4095
FT /note="FIVAR 15"
FT DOMAIN 4163..4221
FT /note="FIVAR 16"
FT DOMAIN 4289..4347
FT /note="FIVAR 17"
FT DOMAIN 4415..4473
FT /note="FIVAR 18"
FT DOMAIN 4541..4599
FT /note="FIVAR 19"
FT DOMAIN 4667..4725
FT /note="FIVAR 20"
FT DOMAIN 4793..4851
FT /note="FIVAR 21"
FT DOMAIN 4919..4977
FT /note="FIVAR 22"
FT DOMAIN 5045..5103
FT /note="FIVAR 23"
FT DOMAIN 5171..5229
FT /note="FIVAR 24"
FT DOMAIN 5297..5355
FT /note="FIVAR 25"
FT DOMAIN 5423..5481
FT /note="FIVAR 26"
FT DOMAIN 5549..5607
FT /note="FIVAR 27"
FT DOMAIN 5675..5733
FT /note="FIVAR 28"
FT DOMAIN 5801..5859
FT /note="FIVAR 29"
FT DOMAIN 6002..6060
FT /note="FIVAR 30"
FT DOMAIN 6128..6186
FT /note="FIVAR 31"
FT DOMAIN 6254..6312
FT /note="FIVAR 32"
FT DOMAIN 6380..6438
FT /note="FIVAR 33"
FT DOMAIN 6506..6564
FT /note="FIVAR 34"
FT DOMAIN 6606..6659
FT /note="FIVAR 35"
FT DOMAIN 6727..6785
FT /note="FIVAR 36"
FT DOMAIN 6853..6911
FT /note="FIVAR 37"
FT DOMAIN 6979..7040
FT /note="FIVAR 38"
FT DOMAIN 7105..7163
FT /note="FIVAR 39"
FT DOMAIN 7231..7289
FT /note="FIVAR 40"
FT DOMAIN 7357..7414
FT /note="FIVAR 41"
FT DOMAIN 7482..7540
FT /note="FIVAR 42"
FT DOMAIN 7608..7666
FT /note="FIVAR 43"
FT DOMAIN 7734..7792
FT /note="FIVAR 44"
FT DOMAIN 7860..7918
FT /note="FIVAR 45"
FT DOMAIN 7986..8044
FT /note="FIVAR 46"
FT DOMAIN 8112..8166
FT /note="FIVAR 47"
FT DOMAIN 8234..8293
FT /note="FIVAR 48"
FT DOMAIN 8488..8544
FT /note="FIVAR 49"
FT REGION 41..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 99..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 250..277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1342..1373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2418..2438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3029..3048
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3203..3595
FT /note="Fibronectin-binding"
FT REGION 9281..9300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 9438..9535
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..130
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9438..9516
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9517..9535
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 9535 AA; 1029924 MW; 76A58B8D05238D9E CRC64;
MNYRDKIQKF SIRKYTVGTF STVIATLVFL GFNTSQAHAA ETNQPASVVK QKQQSNNEQT
ENRESQVQNS QNSQNGQSLS ATHENEQPNI SQANLVDQKV AQSSTTNDEQ PASQNVNTKK
DSATAATTQP DKEQSKHKQN ESQSANKNGN DNRAAHVENH EANVVTASDS SDNGNVQHDR
NELQAFFDAN YHDYRFIDRE NADSGTFNYV KGIFDKINTL LGSNDPINNK DLQLAYKELE
QAVALIRTMP QRQQTSRRSN RIQTRSVESR AAEPRSVSDY QNANSSYYVE NANDGSGYPV
GTYINASSKG APYNLPTTPW NTLKASDSKE IALMTAKQTG DGYQWVIKFN KGHAPHQNMI
FWFALPADQV PVGRTDFVTV NSDGTNVQWS HGAGAGANKP LQQMWEYGVN DPHRSHDFKI
RNRSGQVIYD WPTVHIYSLE DLSRASDYFS EAGATPATKA FGRQNFEYIN GQKPAESPGV
PKVYTFIGQG DASYTISFKT QGPTVNKLYY AAGGRALEYN QLFMYSQLYV ESTQDHQQRL
NGLRQVVNRT YRIGTTKRVE VSQGNVQTKK VLESTNLNID DFVDDPLSYV KTPSNKVLGF
YSNNANTNAF RPGGAQQLNE YQLSQLFTDQ KLQEAARTRN PIRLMIGFDY PDAYGNSETL
VPVNLTVLPE IQHNIKFFKN DDTQNIAEKP FSKQAGHPVF YVYAGNQGNA SVNLGGSVTS
IQPLRINLTS NENFTDKDWQ ITGIPRTLHI ENSTNRPNNA RERNIELVGN LLPGDYFGTI
RFGRKEQLFE IRVKPHTPTI TTTAEQLRGT ALQKVPVNIS GIPLDPSALV YLVAPTNQTT
NGGSEADQIP SGYTILATGT PDGVHNTITI RPQDYVVFIP PVGKQIRAVV YYNKVVASNM
SNAVTILPDD IPPTINNPVG INAKYYRGDE VNFTMGVSDR HSGIKNTTIT TLPNGWTSNL
TKADKNNGSL SITGRVSMNQ AFNSDITFKV SATDNVNNTT NDSQSKHVSI HVGKISEDAH
PIVLGNTEKV VVVNPTAVSN DEKQSIITAF MNKNQNIRGY LASTDPVTVD NNGNVTLHYR
DGSSTTLDAT NVMTYEPVVK PEYQTVNAAK TATVTIAKGQ SFSIGDIKQY FTLSNGQPIP
SGTFTNITSD RTIPTAQEVS QMNAGTQLYH ITATNAYHKD SEDFYISLKI IDVKQPEGDQ
RVYRTSTYDL TTDEISKVKQ AFINANRDVI TLAEGDISVT NTPNGANVST ITVNINKGRL
TKSFASNLAN MNFLRWVNFP QDYTVTWTNA KIANRPTDGG LSWSDDHKSL IYRYDATLGT
QITTNDILTM LKATTTVPGL RNNITGNEKS QAEAGGRPNF RTTGYSQSNA TTDGQRQFTL
NGQVIQVLDI INPSNGYGGQ PVTNSNTRAN HSNSTVVNVN EPAANGAGAF TIDHVVKSNS
THNASDAVYK AQLYLTPYGP KQYVEHLNQN TGNTTDAINI YFVPSDLVNP TISVGNYTNH
QVFSGETFTN TITANDNFGV QSVTVPNTSQ ITGTVDNNHQ HVSATAPNVT SATNKTINLL
ATDTSGNTAT TSFNVTVKPL RDKYRVGTSS TAANPVRIAN ISNNATVSQA DQTTIINSLT
FTETVPNRSY ARASANEITS KTVSNVSRTG NNANVTVTVT YQDGTTSTVT VPVKHVIPEI
VAHSHYTVQG QDFPAGNGSS ASDYFKLSNG SDIADATITW VSGQAPNKDN TRIGEDITVT
AHILIDGETT PITKTATYKV VRTVPKHVFE TARGVLYPGV SDMYDAKQYV KPVNNSWSTN
AQHMNFQFVG TYGPNKDVVG ISTRLIRVTY DNRQTEDLTI LSKVKPDPPR IDANSVTYKA
GLTNQEIKVN NVLNNSSVKL FKADNTPLNV TNITHGSGFS SVVTVSDALP NGGIKAKSSI
SMNNVTYTTQ DEHGQVVTVT RNESVDSNDS ATVTVTPQLQ ATTEGAVFIK GGDGFDFGHV
ERFIQNPPHG ATVAWHDSPD TWKNTVGNTH KTAVVTLPNG QGTRNVEVPV KVYPVANAKA
PSRDVKGQNL TNGTDAMNYI TFDPNTNTNG ITAAWANRQQ PNNQQAGVQH LNVDVTYPGI
SAAKRVPVTV NVYQFEFPQT TYTTTVGGTL ASGTQASGYA HMQNATGLPT DGFTYKWNRD
TTGTNDANWS AMNKPNVAKV VNAKYDVIYN GHTFATSLPA KFVVKDVQPA KPTVTETAAG
AITIAPGANQ TVNTHAGNVT TYADKLVIKR NGNVVTTFTR RNNTSPWVKE ASAATVAGIA
GTNNGITVAA GTFNPADTIQ VVATQGSGET VSDEQRSDDF TVVAPQPNQA TTKIWQNGHI
DITPNNPSGH LINPTQAMDI AYTEKVGNGA EHSKTINVVR GQNNQWTIAN KPDYVTLDAQ
TGKVTFNANT IKPNSSITIT PKAGTGHSVS SNPSTLTAPA AHTVNTTEIV KDYGSNVTAA
EINNAVQVAN KRTATIKNGT AMPTNLAGGS TTTIPVTVTY NDGSTEEVQE SIFTKADKRE
LITAKNHLDD PVSTEGKKPG TITQYNNAMH NAQQQINTAK TEAQQVINNE RATPQQVSDA
LTKVRAAQTK IDQAKALLQN KEDNSQLVTS KNNLQSSVNQ VPSTAGMTQQ SIDNYNAKKR
EAETEITAAQ RVIDNGDATA QQISDEKHRV DNALTALNQA KHDLTADTHA LEQAVQQLNR
TGTTTGKKPA SITAYNNSIR ALQSDLTSAK NSANAIIQKP IRTVQEVQSA LTNVNRVNER
LTQAINQLVP LADNSALKTA KTKLDEEINK SVTTDGMTQS SIQAYENAKR AGQTESTNAQ
NVINNGDATD QQIAAEKTKV EEKYNSLKQA IAGLTPDLAP LQTAKTQLQN DIDQPTSTTG
MTSASIAAFN EKLSAARTKI QEIDRVLASH PDVATIRQNV TAANAAKSAL DQARNGLTVD
KAPLENAKNQ LQHSIDTQTS TTGMTQDSIN AYNAKLTAAR NKIQQINQVL AGSPTVEQIN
TNTSTANQAK SDLDHARQAL TPDKAPLQTA KTQLEQSINQ PTDTTGMTTA SLNAYNQKLQ
AARQKLTEIN QVLNGNPTVQ NINDKVTEAN QAKDQLNTAR QGLTLDRQPA LTTLHGASNL
NQAQQNNFTQ QINAAQNHAA LETIKSNITA LNTAMTKLKD SVADNNTIKS DQNYTDATPA
NKQAYDNAVN AAKGVIGETT NPTMDVNTVN QKAASVKSTK DALDGQQNLQ RAKTEATNAI
THASDLNQAQ KNALTQQVNS AQNVQAVNDI KQTTQSLNTA MTGLKRGVAN HNQVVQSDNY
VNADTNKKND YNNAYNHAND IINGNAQHPV ITPSDVNNAL SNVTSKEHAL NGEAKLNAAK
QEANTALGHL NNLNNAQRQN LQSQINGAHQ IDAVNTIKQN ATNLNSAMGN LRQAVADKDQ
VKRTEDYADA DTAKQNAYNS AVSSAETIIN QTTNPTMSVD DVNRATSAVT SNKNALNGYE
KLAQSKTDAA RAIDALPHLN NAQKADVKSK INAASNIAGV NTVKQQGTDL NTAMGNLQGA
INDEQTTLNS QNYQDATPSK KTAYTNAVQA AKDILNKSNG QNKTKDQVTE AMNQVNSAKN
NLDGTRLLDQ AKQTAKQQLN NMTHLTTAQK TNLTNQINSG TTVAGVQTVQ SNANTLDQAM
NTLRQSIANK DATKASEDYV DANNDKQTAY NNAVAAAETI INANSNPEMN PSTITQKAEQ
VNSSKTALNG DENLAAAKQN AKTYLNTLTS ITDAQKNNLI SQITSATRVS GVDTVKQNAQ
HLDQAMASLQ NGINNESQVK SSEKYRDADT NKQQEYDNAI TAAKAILNKS TGPNTAQNAV
EAALQRVNNA KDALNGDAKL IAAQNAAKQH LGTLTHITTA QRNDLTNQIS QATNLAGVES
VKQNANSLDG AMGNLQTAIN DKSGTLASQN FLDADEQKRN AYNQAVSAAE TILNKQTGPN
TAKTAVEQAL NNVNNAKHAL NGTQNLNNAK QAAITAINGA SDLNQKQKDA LKAQANGAQR
VSNAQDVQHN ATELNTAMGT LKHAIADKTN TLASSKYVNA DSTKQNAYTT KVTNAEHIIS
GTPTVVTTPS EVTAAANQVN SAKQELNGDE RLREAKQNAN TAIDALTQLN TPQKAKLKEQ
VGQANRLEDV QTVQTNGQAL NNAMKGLRDS IANETTVKTS QNYTDASPNN QSTYNSAVSN
AKGIINQTNN PTMDTSAITQ ATTQVNNAKN GLNGAENLRN AQNTAKQNLN TLSHLTNNQK
SAISSQIDRA GHVSEVTATK NAATELNTQM GNLEQAIHDQ NTVKQSVKFT DADKAKRDAY
TNAVSRAEAI LNKTQGANTS KQDVEAAIQN VSSAKNALNG DQNVTNAKNA AKNALNNLTS
INNAQKRDLT TKIDQATTVA GVEAVSNTST QLNTAMANLQ NGINDKTNTL ASENYHDADS
DKKTAYTQAV TNAENILNKN SGSNLDKTAV ENALSQVANA KGALNGNHNL EQAKSNANTT
INGLQHLTTA QKDKLKQQVQ QAQNVAGVDT VKSSANTLNG AMGTLRNSIQ DNTATKNGQN
YLDATERNKT NYNNAVDSAN GVINATSNPN MDANAINQIA TQVTSTKNAL DGTHNLTQAK
QTATNAIDGA TNLNKAQKDA LKAQVTSAQR VANVTSIQQT ANELNTAMGQ LQHGIDDENA
TKQTQKYRDA EQSKKTAYDQ AVAAAKAILN KQTGSNSDKA AVDRALQQVT STKDALNGDA
KLAEAKAAAK QNLGTLNHIT NAQRTDLEGQ INQATTVDGV NTVKTNANTL DGAMNSLQGS
INDKDATLRN QNYLDADESK RNAYTQAVTA AEGILNKQTG GNTSKADVDN ALNAVTRAKA
ALNGADNLRN AKTSATNTID GLPNLTQLQK DNLKHQVEQA QNVAGVNGVK DKGNTLNTAM
GALRTSIQND NTTKTSQNYL DASDSNKNNY NTAVNNANGV INATNNPNMD ANAINGMANQ
VNTTKAALNG AQNLAQAKTN ATNTINNAHD LNQKQKDALK TQVNNAQRVS DANNVQHTAT
ELNSAMTALK AAIADKERTK ASGNYVNADQ EKRQAYDSKV TNAENIISGT PNATLTVNDV
NSAASQVNAA KTALNGDNNL RVAKEHANNT IDGLAQLNNA QKAKLKEQVQ SATTLDGVQT
VKNSSQTLNT AMKGLRDSIA NEATIKAGQN YTDASPNNRN EYDSAVTAAK AIINQTSNPT
MEPNTITQVT SQVTTKEQAL NGARNLAQAK TTAKNNLNNL TSINNAQKDA LTRSIDGATT
VAGVNQETAK ATELNNAMHS LQNGINDETQ TKQTQKYLDA EPSKKSAYDQ AVNAAKAILT
KASGQNVDKA AVEQALQNVN STKTALNGDA KLNEAKAAAK QTLGTLTHIN NAQRTALDNE
ITQATNVEGV NTVKAKAQQL DGAMGQLETS IRDKDTTLQS QNYQDADDAK RTAYSQAVNA
AATILNKTAG GNTPKADVER AMQAVTQANT ALNGIQNLDR AKQAANTAIT NASDLNTKQK
EALKAQVTSA GRVSAANGVE HTATELNTAM TALKRAIADK AETKASGNYV NADANKRQAY
DEKVTAAENI VSGTPTPTLT PADVTNAATQ VTNAKTQLNG NHNLEVAKQN ANTAIDGLTS
LNGPQKAKLK EQVGQATTLP NVQTVRDNAQ TLNTAMKGLR DSIANEATIK AGQNYTDASQ
NKQTDYNSAV TAAKAIIGQT TSPSMNAQEI NQAKDQVTAK QQALNGQENL RTAQTNAKQH
LNGLSDLTDA QKDAVKRQIE GATHVNEVTQ AQNNADALNT AMTNLKNGIQ DQNTIKQGVN
FTDADEAKRN AYTNAVTQAE QILNKAQGPN TSKDGVETAL ENVQRAKNEL NGNQNVANAK
TTAKNALNNL TSINNAQKEA LKSQIEGATT VAGVNQVSTT ASELNTAMSN LQNGINDEAA
TKAALNGTQN LEKAKQHANT AIDGLSHLTN AQKEALKQLV QQSTTVAEAQ GNEQKANNVD
AAMDKLRQSI ADNATTKQNQ NYTDASQNKK DAYNNAVTTA QGIIDQTTSP TLDPTVINQA
AGQVSTTKNA LNGNENLEAA KQQASQSLGS LDNLNNAQKQ TVTDQINGAH TVDEANQIKQ
NAQNLNTAMG NLKQAIADKD ATKATVNFTD ADQAKQQAYN TAVTNAENII SKANGGNATQ
AEVEQAIKQV NAAKQALNGN ANVQHAKDEA TALINSSNDL NQAQKDALKQ QVQNATTVAG
VNNVKQTAQE LNNAMTQLKQ GIADKEQTKA DGNFVNADPD KQNAYNQAVA KAEALISATP
DVVVTPSEIT AALNKVTQAK NDLNGNTNLA TAKQNVQHAI DQLPNLNQAQ RDEYSKQITQ
ATLVPNVNAI QQAATTLNDA MTQLKQGIAN KAQIKGSENY HDADTDKQTA YDNAVTKAEE
LLKQTTNPTM DPNTIQQALT KVNDTNQALN GNQKLADAKQ DAKTTLGTLD HLNDAQKQAL
TTQVEQAPDI ATVNNVKQNA QNLNNAMTNL NNALQDKTET LNSINFTDAD QAKKDAYTNA
VSHAEGILSK ANGSNASQTE VEQAMQRVNE AKQALNGNDN VQRAKDAAKQ VITNANDLNQ
AMTQLKQGIA DKDQTKANGN FVNADTDKQN AYNNAVAHAE QIISGTPNAN VDPQQVAQAL
QQVNQAKGDL NGNHNLQVAK DNANTAIDQL PNLNQPQKTA LKDQVSHAEL VTGVNAIKQN
ADALNNAMGT LKQQIQANSQ VPQSVDFTQA DQDKQQAYNN AANQAQQIAN GIPTPVLTPD
TVTQAVTTMN QAKDALNGDE KLAQAKQEAL ANLDTLRDLN QPQRDALRNQ INQAQALATV
EQTKQNAQNV NTAMSNLKQG IANKDTVKAS ENYHDADADK QTAYTNAVSQ AEGIINQTTN
PTLNPDEITR ALTQVTDAKN GLNGEAKLAT EKQNAKDAVS GMTHLNDAQK QALKGQIDQS
PEIATVNQVK QTATSLDQAM DQLSQAINDK AQTLADGNYL NADPDKQNAY KQAVAKAEAL
LNKQSGTNEV QAQVESITNE VNAAKQALNG NDNLANAKQQ AKQQLANLTH LNDAQKQSFE
SQITQAPLVT DVTTINQKAQ TLDHAMELLR NSVADNQTTL ASEDYHDATA QRQNDYNQAV
TAANNIINQT TSPTMNPDDV NGATTQVNNT KVALDGDENL AAAKQQANNR LDQLDHLNNA
QKQQLQSQIT QSSDIAAVNG HKQTAESLNT AMGNLINAIA DHQAVEQRGN FINADTDKQT
AYNTAVNEAA AMINKQTGQN ANQTEVEQAI TKVQTTLQAL NGDHNLQVAK TNATQAIDAL
TSLNDPQKTA LKDQVTAATL VTAVHQIEQN ANTLNQAMHG LRQSIQDNAA TKANSKYINE
DQPEQQNYDQ AVQAANNIIN EQTATLDNNA INQAATTVNT TKAALHGDVK LQNDKDHAKQ
TVSQLAHLNN AQKHMEDTLI DSETTRTAVK QDLTEAQALD QLMDALQQSI ADKDATRASS
AYVNAEPNKK QSYDEAVQNA ESIIAGLNNP TINKGNVSSA TQAVISSKNA LDGVERLAQD
KQTAGNSLNH LDQLTPAQQQ ALENQINNAT TRDKVAEIIA QAQALNEAMK ALKESIKDQP
QTEASSKFIN EDQAQKDAYT QAVQHAKDLI NKTTDPTLAK SIIDQATQAV TDAKNNLHGD
QKLAQDKQRA TETLNNLSNL NTPQRQALEN QINNAATRGE VAQKLTEAQA LNQAMEALRN
SIQDQQQTEA GSKFINEDKP QKDAYQAAVQ NAKDLINQTN NPTLDKAQVE QLTQAVNQAK
DNLHGDQKLA DDKQHAVTDL NQLNGLNNPQ RQALESQINN AATRGEVAQK LAEAKALDQA
MQALRNSIQD QQQTESGSKF INEDKPQKDA YQAAVQNAKD LINQTGNPTL DKSQVEQLTQ
AVTTAKDNLH GDQKLARDQQ QAVTTVNALP NLNHAQQQAL TDAINAAPTR TEVAQHVQTA
TELDHAMETL KNKVDQVNTD KAQPNYTEAS TDKKEAVDQA LQAAESITDP TNGSNANKDA
VDQVLTKLQE KENELNGNER VAEAKTQAKQ TIDQLTHLNA DQIATAKQNI DQATKLQPIA
ELVDQATQLN QSMDQLQQAV NEHANVEQTV DYTQADSDKQ NAYKQAIADA ENVLKQNANK
QQVDQALQNI LNAKQALNGD ERVALAKTNG KHDIDQLNAL NNAQQDGFKG RIDQSNDLNQ
IQQIVDEAKA LNRAMDQLSQ EITDNEGRTK GSTNYVNADT QVKQVYDETV DKAKQALDKS
TGQNLTAKQV IKLNDAVTAA KKALNGEERL NNRKAEALQR LDQLTHLNNA QRQLAIQQIN
NAETLNKASR AINRATKLDN AMGSVQQYID EQHLGVISST NYINADDNLK ANYDNAIANA
AHELDKVQGN AIAKAEAEQL KQNIIDAQNA LNGDQNLANA KDKANAFVNS LNGLNQQQQD
LAHKAINNAD TVSDVTDIVN NQIDLNDAME TLKHLVDNEI PNAEQTVNYQ NADDNAKTNF
DDAKRLANTL LNSDNTNVND INGAIQAVND AIHNLNGDQR LQDAKDKAIQ SINQALANKL
KEIEASNATD QDKLIAKNKA EELANSIINN INKATSNQAV SQVQTAGNHA IEQVHANEIP
KAKIDANKDV DKQVQALIDE IDRNPNLTDK EKQALKDRIN QILQQGHNGI NNAMTKEEIE
QAKAQLAQAL QDIKDLVKAK EDAKQDVDKQ VQALIDEIDQ NPNLTDKEKQ ALKDRINQIL
QQGHNDINNA MTKEAIEQAK ERLAQALQDI KDLVKAKEDA KNDIDKRVQA LIDEIDQNPN
LTDKEKQALK DRINQILQQG HNDINNALTK EEIEQAKAQL AQALQDIKDL VKAKEDAKNA
IKALANAKRD QINSNPDLTP EQKAKALKEI DEAEKRALQN VENAQTIDQL NRGLNLGLDD
IRNTHVWEVD EQPAVNEIFE ATPEQILVNG ELIVHRDDII TEQDILAHIN LIDQLSAEVI
DTPSTATISD SLTAKVEVTL LDGSKVIVNV PVKVVEKELS VVKQQAIESI ENAAQQKINE
INNSVTLTLE QKEAAIAEVN KLKQQAIDHV NNAPDVHSVE EIQQQEQAHI EQFNPEQFTI
EQAKSNAIKS IEDAIQHMID EIKARTDLTD KEKQEAIAKL NQLKEQAIQA IQRAQSIDEI
SEQLEQFKAQ MKAANPTAKE LAKRKQEAIS RIKDFSNEKI NSIRNSEIGT ADEKQAAMNQ
INEIVLETIR DINNAHTLQQ VEAALNNGIA RISAVQIVTS DRAKQSSSTG NESNSHLTIG
YGTANHPFNS STIGHKKKLD EDDDIDPLHM RHFSNNFGNV IKNAIGVVGI SGLLASFWFF
IAKRRRKEDE EEELEIRDNN KDSIKETLDD TKHLPLLFAK RRRKEDEEDV TVEEKDSLNN
GESLDKVKHT PFFLPKRRRK EDEEDVEVTN ENTDEKVLKD NEHSPLLFAK RRKDKEEDVE
TTTSIESKDE DVPLLLAKKK NQKDNQSKDK KSASKNTSKK VAAKKKKKKA KKNKK
