ID   EBLN1_HUMAN             Reviewed;         366 AA.
AC   P0CF75; S4R316;
DT   18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT   19-MAR-2014, sequence version 2.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Endogenous Bornavirus-like nucleoprotein 1;
DE   AltName: Full=Endogenous Borna-like N element-1;
DE            Short=EBLN-1;
GN   Name=EBLN1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA   Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA   Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA   Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA   Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA   Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA   Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA   Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA   McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA   Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA   Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA   Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA   Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA   Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA   Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA   Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   SIMILARITY WITH BORNAVIRUS NUCLEOCAPSID.
RX   PubMed=20054395; DOI=10.1038/nature08695;
RA   Horie M., Honda T., Suzuki Y., Kobayashi Y., Daito T., Oshida T., Ikuta K.,
RA   Jern P., Gojobori T., Coffin J.M., Tomonaga K.;
RT   "Endogenous non-retroviral RNA virus elements in mammalian genomes.";
RL   Nature 463:84-87(2010).
CC   -!- FUNCTION: May act as an RNA-binding protein. Highly homologous to the
CC       bornavirus nucleocapsid N protein that binds viral RNA and oligomerizes
CC       (By similarity). {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expression detected by RT-PCR in a few cell lines,
CC       including OL, HEK293T and MOLT-4. Not observed in HeLa cells
CC       (PubMed:20054395). {ECO:0000269|PubMed:20054395}.
CC   -!- MISCELLANEOUS: Bornavirus is a non-retroviral RNA virus that does not
CC       generate DNA forms during viral replication. Therefore, integration of
CC       EBLN-1 must have occur through a mechanism relying on an endogenous
CC       reverse transcriptase activity.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL157831; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471072; EAW86159.1; -; Genomic_DNA.
DR   CCDS; CCDS60498.1; -.
DR   RefSeq; NP_001186867.1; NM_001199938.1.
DR   AlphaFoldDB; P0CF75; -.
DR   SMR; P0CF75; -.
DR   BioGRID; 131105; 3.
DR   IntAct; P0CF75; 2.
DR   STRING; 9606.ENSP00000473842; -.
DR   iPTMnet; P0CF75; -.
DR   PhosphoSitePlus; P0CF75; -.
DR   BioMuta; EBLN1; -.
DR   DMDM; 296537812; -.
DR   EPD; P0CF75; -.
DR   PeptideAtlas; P0CF75; -.
DR   PRIDE; P0CF75; -.
DR   DNASU; 340900; -.
DR   Ensembl; ENST00000422359.3; ENSP00000473842.1; ENSG00000223601.3.
DR   GeneID; 340900; -.
DR   KEGG; hsa:340900; -.
DR   MANE-Select; ENST00000422359.3; ENSP00000473842.1; NM_001394757.1; NP_001381686.1.
DR   UCSC; uc021pob.2; human.
DR   CTD; 340900; -.
DR   GeneCards; EBLN1; -.
DR   HGNC; HGNC:39430; EBLN1.
DR   HPA; ENSG00000223601; Tissue enriched (testis).
DR   MIM; 613249; gene.
DR   neXtProt; NX_P0CF75; -.
DR   OpenTargets; ENSG00000223601; -.
DR   VEuPathDB; HostDB:ENSG00000223601; -.
DR   eggNOG; ENOG502TDPR; Eukaryota.
DR   GeneTree; ENSGT00490000044176; -.
DR   HOGENOM; CLU_756391_0_0_1; -.
DR   InParanoid; P0CF75; -.
DR   OMA; ANYWAKR; -.
DR   OrthoDB; 684241at2759; -.
DR   PathwayCommons; P0CF75; -.
DR   SignaLink; P0CF75; -.
DR   BioGRID-ORCS; 340900; 21 hits in 1035 CRISPR screens.
DR   GenomeRNAi; 340900; -.
DR   Pharos; P0CF75; Tdark.
DR   PRO; PR:P0CF75; -.
DR   Proteomes; UP000005640; Chromosome 10.
DR   RNAct; P0CF75; protein.
DR   Bgee; ENSG00000223601; Expressed in right testis and 2 other tissues.
DR   Gene3D; 1.10.3040.10; -; 1.
DR   Gene3D; 1.10.3050.10; -; 1.
DR   InterPro; IPR009441; P40_nucleoprot_BD-vir.
DR   InterPro; IPR036260; P40_nucleoprot_sf_BD-vir.
DR   InterPro; IPR015969; P40_nucleoprot_sub1_BD-vir.
DR   InterPro; IPR015970; P40_nucleoprot_sub2_BD-vir.
DR   Pfam; PF06407; BDV_P40; 1.
DR   SUPFAM; SSF101399; SSF101399; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..366
FT                   /note="Endogenous Bornavirus-like nucleoprotein 1"
FT                   /id="PRO_0000393911"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        149
FT                   /note="G -> R (in Ref. 2; EAW86159)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        235
FT                   /note="M -> T (in Ref. 2; EAW86159)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   366 AA;  40313 MW;  DA7E68FDB877E53A CRC64;
     MSRPRNNPQT SSPQDSTKDG SSFHYFQGRF ELSGKSRQYP ADALEPQPGI GDVKVIEKAT
     KSMLDPAQRS HFYLVTPSLV FLCFIFDGLH KALLSVGVSK RSNIVIGNEN KETGTLYASK
     FEDVLPTFTA LEMSSILRHC CDLIGIAAGS SDPICTNSLQ VQRQFKAMMI SIGRPLHSES
     ADLLISYNAG PAIDWINSRP WVGGLMFTFL FGEFESPACE LLDQVKVVAS KAQMMTYYTV
     RMFLDQCVDG STALPAVVLE IPVFEQKKPL AKKVLGDFFE FGGVLRHPVI GVLSPQMFPN
     LATAANYWAK RRNSTFSGFE ALDIIPGSTI TFPVLQMASA QKISRGSDMD PYTLNILRGY
     GISGFE