ID   EBLN2_HUMAN             Reviewed;         272 AA.
AC   Q6P2I7; Q8WWH3; Q9NW89;
DT   16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Endogenous Bornavirus-like nucleoprotein 2;
DE   AltName: Full=Endogenous Borna-like N element-2;
DE            Short=EBLN-2;
GN   Name=EBLN2; ORFNames=GK006;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Hepatoma;
RA   Xu X., Huang J., Rong Y., Xiao H., Chen Z., Han Z.;
RL   Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA   Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA   Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA   Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA   Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA   Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA   Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA   Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA   Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA   Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA   Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA   Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA   Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA   Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA   Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA   Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 65-272.
RC   TISSUE=Embryo;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [5]
RP   SIMILARITY WITH BORNAVIRUS NUCLEOCAPSID.
RX   PubMed=20054395; DOI=10.1038/nature08695;
RA   Horie M., Honda T., Suzuki Y., Kobayashi Y., Daito T., Oshida T., Ikuta K.,
RA   Jern P., Gojobori T., Coffin J.M., Tomonaga K.;
RT   "Endogenous non-retroviral RNA virus elements in mammalian genomes.";
RL   Nature 463:84-87(2010).
CC   -!- FUNCTION: May act as an RNA-binding protein. The C-terminal region is
CC       highly homologous to the bornavirus nucleocapsid N protein that binds
CC       viral RNA and oligomerizes. The viral protein also possesses a nuclear
CC       import and a nuclear export signal. These 2 signals seem absent in
CC       EBLN-2 supporting an unrelated function in Human.
CC   -!- MISCELLANEOUS: Bornavirus is a non-retroviral RNA virus that does not
CC       generate DNA forms during viral replication. Therefore, integration of
CC       EBLN-2 must have occur through a mechanism relying on an endogenous
CC       reverse transcriptase activity.
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DR   EMBL; AY036895; AAK83528.1; -; mRNA.
DR   EMBL; AC103559; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC051316; AAH51316.1; -; mRNA.
DR   EMBL; BC064501; AAH64501.1; -; mRNA.
DR   EMBL; AK001075; BAA91494.1; -; mRNA.
DR   CCDS; CCDS54608.1; -.
DR   RefSeq; NP_060499.3; NM_018029.4.
DR   AlphaFoldDB; Q6P2I7; -.
DR   SMR; Q6P2I7; -.
DR   BioGRID; 120408; 10.
DR   STRING; 9606.ENSP00000432104; -.
DR   iPTMnet; Q6P2I7; -.
DR   PhosphoSitePlus; Q6P2I7; -.
DR   BioMuta; EBLN2; -.
DR   DMDM; 74737218; -.
DR   PaxDb; Q6P2I7; -.
DR   PeptideAtlas; Q6P2I7; -.
DR   PRIDE; Q6P2I7; -.
DR   Antibodypedia; 76899; 69 antibodies from 6 providers.
DR   DNASU; 55096; -.
DR   Ensembl; ENST00000533473.1; ENSP00000432104.1; ENSG00000255423.1.
DR   GeneID; 55096; -.
DR   KEGG; hsa:55096; -.
DR   MANE-Select; ENST00000533473.1; ENSP00000432104.1; NM_018029.4; NP_060499.3.
DR   UCSC; uc003dpj.4; human.
DR   CTD; 55096; -.
DR   GeneCards; EBLN2; -.
DR   HGNC; HGNC:25493; EBLN2.
DR   HPA; ENSG00000255423; Tissue enhanced (bone).
DR   MIM; 613250; gene.
DR   neXtProt; NX_Q6P2I7; -.
DR   OpenTargets; ENSG00000255423; -.
DR   VEuPathDB; HostDB:ENSG00000255423; -.
DR   eggNOG; ENOG502TDPR; Eukaryota.
DR   GeneTree; ENSGT00490000044176; -.
DR   HOGENOM; CLU_089340_0_0_1; -.
DR   OMA; KSHFHPV; -.
DR   OrthoDB; 684241at2759; -.
DR   PhylomeDB; Q6P2I7; -.
DR   PathwayCommons; Q6P2I7; -.
DR   BioGRID-ORCS; 55096; 7 hits in 1065 CRISPR screens.
DR   GenomeRNAi; 55096; -.
DR   Pharos; Q6P2I7; Tdark.
DR   PRO; PR:Q6P2I7; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   RNAct; Q6P2I7; protein.
DR   Bgee; ENSG00000255423; Expressed in buccal mucosa cell and 183 other tissues.
DR   Genevisible; Q6P2I7; HS.
DR   Gene3D; 1.10.3040.10; -; 1.
DR   InterPro; IPR009441; P40_nucleoprot_BD-vir.
DR   InterPro; IPR036260; P40_nucleoprot_sf_BD-vir.
DR   InterPro; IPR015969; P40_nucleoprot_sub1_BD-vir.
DR   Pfam; PF06407; BDV_P40; 1.
DR   SUPFAM; SSF101399; SSF101399; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..272
FT                   /note="Endogenous Bornavirus-like nucleoprotein 2"
FT                   /id="PRO_0000358716"
FT   REGION          48..70
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        176
FT                   /note="A -> G (in Ref. 1; AAK83528)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   272 AA;  30450 MW;  7937378569396D7D CRC64;
     MGYFLKLYAY VNSHSLFVWV CDRSYKRSFR PMILNKIKEL SRNQFSTMSH LRKDSQPSSP
     GDDAMDRSGL PDLQGRFELS GKNRQYPLDA LEPQPSIGDI KDIKKAAKSM LDPAHKSHFH
     PVTPSLVFLC FIFDGLHQAL LSVGVSKRSN TVVGNENEER GTPYASRFKD MPNFIALEKS
     SVLRHCCDLL IGIAAGSSDK ICTSSLQVQR RFKAMMASIG RLSHGESADL LISCNAESAI
     GWISSRPWVG ELMFTLLFGD FESPLHKLRK SS