ID   EBNA3_EBVG              Reviewed;         935 AA.
AC   Q3KST2;
DT   26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-MAY-2009, sequence version 2.
DT   29-SEP-2021, entry version 53.
DE   RecName: Full=Epstein-Barr nuclear antigen 3;
DE            Short=EBNA-3;
DE            Short=EBV nuclear antigen 3;
DE   AltName: Full=Epstein-Barr nuclear antigen 3A;
DE            Short=EBNA-3A;
DE            Short=EBV nuclear antigen 3A;
GN   Name=EBNA3; ORFNames=BLRF3-BERF1;
OS   Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus.
OX   NCBI_TaxID=10376;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16306603; DOI=10.1128/jvi.79.24.15323-15330.2005;
RA   Zeng M.-S., Li D.-J., Liu Q.-L., Song L.-B., Li M.-Z., Zhang R.-H.,
RA   Yu X.-J., Wang H.-M., Ernberg I., Zeng Y.-X.;
RT   "Genomic sequence analysis of Epstein-Barr virus strain GD1 from a
RT   nasopharyngeal carcinoma patient.";
RL   J. Virol. 79:15323-15330(2005).
CC   -!- FUNCTION: Plays an essential role for activation and immortalization of
CC       human B-cells. Represses transcription of viral promoters TP1 and Cp
CC       through interaction with host RBPJ, and inhibits EBNA2-mediated
CC       activation of these promoters. Since Cp is the promoter for all EBNA
CC       mRNAs, EBNA3A probably contributes to a negative autoregulatory control
CC       loop (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with human UCKL1. Interacts with host CTPB1; this
CC       interaction seems important for EBNA3-mediated transcriptional
CC       repression. Interacts with host RBPJ (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus matrix. Note=Associated with the
CC       nuclear matrix. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the herpesviridae EBNA-3 family. {ECO:0000305}.
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DR   EMBL; AY961628; AAY41118.1; ALT_SEQ; Genomic_DNA.
DR   PDB; 1MI5; X-ray; 2.50 A; C=325-333.
DR   PDB; 3SJV; X-ray; 3.10 A; C/H/M/R=325-333.
DR   PDB; 3SKM; X-ray; 1.80 A; C=325-331.
DR   PDB; 3SKO; X-ray; 1.60 A; C=325-333.
DR   PDBsum; 1MI5; -.
DR   PDBsum; 3SJV; -.
DR   PDBsum; 3SKM; -.
DR   PDBsum; 3SKO; -.
DR   SMR; Q3KST2; -.
DR   ELM; Q3KST2; -.
DR   IntAct; Q3KST2; 4.
DR   Proteomes; UP000007641; Genome.
DR   GO; GO:0044204; C:host cell nuclear matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0016032; P:viral process; IEA:InterPro.
DR   InterPro; IPR007706; EBNA-3/4/6.
DR   Pfam; PF05009; EBV-NA3; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Host nucleus; Host-virus interaction; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..935
FT                   /note="Epstein-Barr nuclear antigen 3"
FT                   /id="PRO_0000375936"
FT   REGION          1..89
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          342..373
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          399..446
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          611..634
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          883..908
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        42..72
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        614..630
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   935 AA;  102426 MW;  DABB76CCC45C2E5C CRC64;
     MDKDRPGDPA LDDNMEEEVP STSVVQEQVS AGDWENVLIE LSDSSSEKEA EDAQLEPAQK
     GTKRKRVDHD AGGSAPARPM LPPQPDLPGR EAILRRFPLD LRTLLQAIGA AATRIDTRAI
     DQFFGSQISN TEMYIMYAMA IRQAIRDRRR NPASRRDQAK WRLQTLAAGW PMGYQAYSSW
     MYSYTDHQTA PTFVQLQATL GCTGGRRCHV TFSAGTFKPP RCTPGDRQWL YVQSSVGNIV
     QSCNPRYSIF FDYMAIHRSL TKIWEEVLTP DQRVSFMEFL GFLQRTDLSY IKSFVSDALG
     TTSIQTPWID DNSSTETAQA WNAGFLRGRA YGLDLLRTEG EHVEGATGET REESEDTESD
     GDDEDLPCIV SRGGPKVKRP PIFIRRLHRL LLMRAGKRTE QGKEVLEKAR GSTYGTPRPP
     VPKPRPEVPQ SDETATSHGS AQVPEPPTIH LAAQGMAYPL HEQRGMAPCP VAQAPHTPLP
     PVSPGDQLPG VSSDGRVACA PVPAPAGPIV RPWEPSLTQA AGQAFAPVRP QHMPVEPVPV
     PTVALERPVY PKPVRPAPPK IAMQGPGETS GIRRARERWR PAPWTPNPPR SPSQMSVRDR
     LARLRAEAQV KQASVEVQPP QVTQVSPQQP MEGPGAPFSQ VADVVHTPGV PAMQPQYFDL
     PLIQPISQGA PVAPLRASMG PVPPVPATQP QYFDIPLTEP INQGASAAHF LPQQPMEGPL
     VPEQWMFPGA ALSQSVRPGV AQSQYFDLPL TQPITHGAPA AHFLHQPPME GPWVPEQWMF
     QGAPPSQGTD VVQHQLDALG YPLHALNHPG VPVSPAVNQY HLSQAAFGLP IDEDESGEGS
     DTSEPCEALD LSIHGRPCPQ APEWPVQGEG GQDATEVLDL SIHGRPRPRT PEWPVQGESG
     QNVTDHEPRR VVVSAIVHMC QDDEFPDLQD PPDEA