ID   EBNA4_EBVA8             Reviewed;         946 AA.
AC   Q1HVG4;
DT   26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-MAY-2009, sequence version 2.
DT   29-SEP-2021, entry version 48.
DE   RecName: Full=Epstein-Barr nuclear antigen 4;
DE            Short=EBNA-4;
DE            Short=EBV nuclear antigen 4;
DE   AltName: Full=Epstein-Barr nuclear antigen 3B;
DE            Short=EBNA-3B;
DE            Short=EBV nuclear antigen 3B;
GN   Name=EBNA4; ORFNames=BERF2A-BERF2B;
OS   Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus.
OX   NCBI_TaxID=82830;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16490228; DOI=10.1016/j.virol.2006.01.015;
RA   Dolan A., Addison C., Gatherer D., Davison A.J., McGeoch D.J.;
RT   "The genome of Epstein-Barr virus type 2 strain AG876.";
RL   Virology 350:164-170(2006).
CC   -!- FUNCTION: May be involved in transcriptional regulation of both viral
CC       and cellular genes by interacting with the host DNA-binding protein
CC       RBPJ. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts (via N-terminus) with host RBPJ. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus.
CC   -!- SIMILARITY: Belongs to the herpesviridae EBNA-4 family. {ECO:0000305}.
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DR   EMBL; DQ279927; ABB89244.1; ALT_SEQ; Genomic_DNA.
DR   PRIDE; Q1HVG4; -.
DR   Proteomes; UP000007639; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016032; P:viral process; IEA:InterPro.
DR   InterPro; IPR007706; EBNA-3/4/6.
DR   Pfam; PF05009; EBV-NA3; 1.
PE   3: Inferred from homology;
KW   Host nucleus; Host-virus interaction; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..946
FT                   /note="Epstein-Barr nuclear antigen 4"
FT                   /id="PRO_0000375938"
FT   REGION          1..90
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          356..400
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          431..467
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          560..636
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          678..762
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          858..946
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        68..82
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        356..379
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        575..618
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        699..761
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        893..919
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        932..946
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   946 AA;  104104 MW;  7F428D409134E869 CRC64;
     MKKAWLSRAQ QADAGGASGS EDPPDYGDQG NVQQVGSDPI SPAIGPFELS AASEDDPQSG
     PVEENLDAAA REEEEPDEQE HNGGDDPLEV HTRQPRFVDV NPTQAPVIQL VHAVYDSMLQ
     SDLRSLGSLF LEQNLNIEEF IWMCMTVRHR CQAIRQKPLP IDKQRRWKLL SPYRTWRMGY
     RTQTLNVNSF ETGGDKVHPL LVTATLGCEE GLRHAITYSA GIVQLPRMSD QNQKIETAFL
     MARRARSLSA ERYTLFFDLV SSGNTLYAIW IGLGTRNRVA FVEFVGWLCK KDHTHIREWF
     RQCTGRPSPS KPWMRAHPVA VPYDDPLTSE ETDLAYARGL AMSIEAARLP DDPIIVEDDD
     ESEEIEDKCD KDEEESGTED VTSIPQTLPH SPTVYGRPSV FYRKPDTKST KKCRAIVTDL
     SIIKVIEDEH RKKKTARTEQ PRAKPDSPAP TVVLRRPPTQ KVTGPAGSLS VQAQLEPWQP
     LSWPHETRVI LHGPPTQGDQ AHGSMLDLLE KDDQHMEQQV MATLLPPEPH QPRSGRRAPC
     VYTADLDIES DEPATSEPVL DQLLPAPGLG PLAIQPLTSP TTSQLRSSAP SHAQTPWPVT
     HPSQTPGGPT TQSLAPETEA PRQWPMPLRP IPLHPLRMQP ISFNPAVRPT PHQPPQVEPT
     FYQSTWVKPP QQYQPQMGHI PYQPRPTGHS TMLRPQWAPT TMQPPPRAPT PMPPPQGPPT
     AMQRPQGAPT PMPPPQGPPT AMQRPRGAPT PMPPPQGPPT AMQLSPRALT GQKGPAKHIL
     RQLLTGGVKS GRPSLKFKAA LERQAAAGLR PSPGSGTGAK IVQAPVFYPP VLQPIQVMWQ
     VGSSKAVAAS TVTQAPTEYT GERRLGGPMS PTDIPPSKRV KKKAYPERKT PHGGPSHSST
     VMWENVSQGQ QQTLECGGTD KQERNMLGMG DIAVSSPSSS ETSNDE