EBNA4_EBVB9
ID EBNA4_EBVB9 Reviewed; 938 AA.
AC P03203; Q777E8;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1990, sequence version 3.
DT 23-FEB-2022, entry version 99.
DE RecName: Full=Epstein-Barr nuclear antigen 4;
DE Short=EBNA-4;
DE Short=EBV nuclear antigen 4;
DE AltName: Full=Epstein-Barr nuclear antigen 3B;
DE Short=EBNA-3B;
DE Short=EBV nuclear antigen 3B;
GN Name=EBNA4; ORFNames=BERF2A-BERF2B;
OS Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus.
OX NCBI_TaxID=10377;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=6087149; DOI=10.1038/310207a0;
RA Baer R., Bankier A.T., Biggin M.D., Deininger P.L., Farrell P.J.,
RA Gibson T.J., Hatfull G., Hudson G.S., Satchwell S.C., Seguin C.,
RA Tuffnell P.S., Barrell B.G.;
RT "DNA sequence and expression of the B95-8 Epstein-Barr virus genome.";
RL Nature 310:207-211(1984).
RN [2]
RP CHARACTERIZATION.
RX PubMed=2157061; DOI=10.1128/jvi.64.4.1812-1816.1990;
RA Kerdiles B., Walls D., Triki H., Perricaudet M., Joab I.;
RT "cDNA cloning and transient expression of the Epstein-Barr virus-determined
RT nuclear antigen EBNA3B in human cells and identification of novel
RT transcripts from its coding region.";
RL J. Virol. 64:1812-1816(1990).
RN [3]
RP SUBCELLULAR LOCATION.
RX PubMed=2161150; DOI=10.1016/0042-6822(90)90027-o;
RA Petti L., Sample C., Kieff E.;
RT "Subnuclear localization and phosphorylation of Epstein-Barr virus latent
RT infection nuclear proteins.";
RL Virology 176:563-574(1990).
RN [4]
RP INTERACTION WITH HUMAN RBPJ.
RX PubMed=8627785; DOI=10.1128/jvi.70.5.3068-3074.1996;
RA Robertson E.S., Lin J., Kieff E.;
RT "The amino-terminal domains of Epstein-Barr virus nuclear proteins 3A, 3B,
RT and 3C interact with RBPJ(kappa).";
RL J. Virol. 70:3068-3074(1996).
CC -!- FUNCTION: May be involved in transcriptional regulation of both viral
CC and cellular genes by interacting with the host DNA-binding protein
CC RBPJ.
CC -!- SUBUNIT: Interacts (via N-terminus) with host RBPJ.
CC {ECO:0000269|PubMed:8627785}.
CC -!- INTERACTION:
CC P03203; Q06330: RBPJ; Xeno; NbExp=4; IntAct=EBI-9346250, EBI-632552;
CC -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000269|PubMed:2161150}.
CC -!- SIMILARITY: Belongs to the herpesviridae EBNA-4 family. {ECO:0000305}.
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DR EMBL; V01555; CAA24858.1; -; Genomic_DNA.
DR EMBL; AJ507799; CAD53420.1; -; Genomic_DNA.
DR PIR; S33012; QQBE24.
DR RefSeq; YP_401670.1; NC_007605.1.
DR BioGRID; 971805; 6.
DR DIP; DIP-573N; -.
DR IntAct; P03203; 11.
DR MINT; P03203; -.
DR PRIDE; P03203; -.
DR GeneID; 3783763; -.
DR Proteomes; UP000153037; Genome.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0016032; P:viral process; IEA:InterPro.
DR InterPro; IPR007706; EBNA-3/4/6.
DR Pfam; PF05009; EBV-NA3; 1.
PE 1: Evidence at protein level;
KW Host nucleus; Host-virus interaction; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..938
FT /note="Epstein-Barr nuclear antigen 4"
FT /id="PRO_0000116178"
FT REGION 1..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 360..389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 430..470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 528..628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 694..752
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 849..870
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 910..938
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..92
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 360..374
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 441..458
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 575..612
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 696..752
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 938 AA; 102860 MW; 98A513AAFC0676FD CRC64;
MKKAWLSRAQ QADAGGASGS EDPPDYGDQG NVTQVGSEPI SPEIGPFELS AASEDDPQSG
PVEENLDAAA REEEEPHEQE HNGGDDPLDV HTRQPRFVDV NPTQAPVIQL VHAVYDSMLQ
SDLRPLGSLF LEQNLNIEEF IWMCMTVRHR CQAIRKKPLP IVKQRRWKLL SSCRSWRMGY
RTHNLKVNSF ESGGDNVHPV LVTATLGCDE GTRHATTYSA GIVQIPRISD QNQKIETAFL
MARRARSLSA ERYTLFFDLV SSGNTLYAIW IGLGTKNRVS FIEFVGWLCK KDHTHIREWF
RQCTGRPKAA KPWLRAHPVA IPYDDPLTNE EIDLAYARGQ AMNIEAPRLP DDPIIVEDDD
ESEEIEAESD EEEDKSGMES LKNIPQTLPY NPTVYGRPAV FDRKSDAKST KKCRAIVTDF
SVIKAIEEEH RKKKAARTEQ PRATPESQAP TVVLQRPPTQ QEPGPVGPLS VQARLEPWQP
LPGPQVTAVL LHEESMQGVQ VHGSMLDLLE KDDEVMEQRV MATLLPPVPQ QPRAGRRGPC
VFTGDLGIES DEPASTEPVH DQLLPAPGPD PLEIQPLTSP TTSQLSSSAP SCAQTPWPVV
QPSQTPDDPT KQSRPPETAA PRQWPMPLRP IPMRPLRMQP IPFNHPVGPT PHQTPQVEIT
PYKPTWAQIG HIPYQPTPTG PATMLLRQWA PATMQTPPRA PTPMSPPEVP PVPRQRPRGA
PTPTPPPQVP PVPRQRPRGA PTPTPPPQVL PTPMQLALRA PAGQQGPTKQ ILRQLLTGGV
KKGRPSLKLQ AALERQAAAG WQPSPGSGTS DKIVQAPIFY PPVLQPIQVM GQGGSPTAMA
ASAVTQAPTE YTRERRGVGP MPPTDIPPSK RAKIEAYTEP EMPHGGASHS PVVILENVGQ
GQQQTLECGG TAKQERDMLG LGDIAVSSPS SSETSNDE
