ID   EBNA4_EBVG              Reviewed;         938 AA.
AC   Q3KST1;
DT   26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   29-SEP-2021, entry version 44.
DE   RecName: Full=Epstein-Barr nuclear antigen 4;
DE            Short=EBNA-4;
DE            Short=EBV nuclear antigen 4;
DE   AltName: Full=Epstein-Barr nuclear antigen 3B;
DE            Short=EBNA-3B;
DE            Short=EBV nuclear antigen 3B;
GN   Name=EBNA4; ORFNames=BERF2A-BERF2B;
OS   Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus.
OX   NCBI_TaxID=10376;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16306603; DOI=10.1128/jvi.79.24.15323-15330.2005;
RA   Zeng M.-S., Li D.-J., Liu Q.-L., Song L.-B., Li M.-Z., Zhang R.-H.,
RA   Yu X.-J., Wang H.-M., Ernberg I., Zeng Y.-X.;
RT   "Genomic sequence analysis of Epstein-Barr virus strain GD1 from a
RT   nasopharyngeal carcinoma patient.";
RL   J. Virol. 79:15323-15330(2005).
CC   -!- FUNCTION: May be involved in transcriptional regulation of both viral
CC       and cellular genes by interacting with the host DNA-binding protein
CC       RBPJ. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts (via N-terminus) with host RBPJ. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus.
CC   -!- SIMILARITY: Belongs to the herpesviridae EBNA-4 family. {ECO:0000305}.
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DR   EMBL; AY961628; AAY41119.1; -; Genomic_DNA.
DR   IntAct; Q3KST1; 2.
DR   PRIDE; Q3KST1; -.
DR   Proteomes; UP000007641; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016032; P:viral process; IEA:InterPro.
DR   InterPro; IPR007706; EBNA-3/4/6.
DR   Pfam; PF05009; EBV-NA3; 1.
PE   3: Inferred from homology;
KW   Host nucleus; Host-virus interaction; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..938
FT                   /note="Epstein-Barr nuclear antigen 4"
FT                   /id="PRO_0000375937"
FT   REGION          1..92
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          360..389
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          431..471
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          560..626
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          694..767
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          834..870
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          919..938
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        66..92
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        360..374
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        441..455
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        575..611
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        696..754
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        834..848
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   938 AA;  102923 MW;  9900051C4F55CD21 CRC64;
     MKKAWLSRAR QADAGGASGS EDPPDYGDQG NVQQVGSGPI SPEIGPFELS AASEDDPQSG
     PVEENLDAAA REEQEPHEQE HNGGDDPLDV HTRQPRFVDV NPTQAPVIQL VHAVYDSMLQ
     SDLRPLGSLF LEQNLNIEEF IWMCMTVRHR CQAIRKKPLP IVKQRRWKLL SSCRSWRMGY
     RTHNLKVNSF ESGGDNVHPV LVTATLGCDE GTRHATTYSA GIVQIPRISD QNQKIETAFL
     MARRARSLSA ERYTLFFDLV SSGNTLYAIW IGLGTKNRVS FIEFVGWLCK KDHTHIREWF
     RQCTGRPKAA KPWLRAHPVA IPYDDPLTNE EIDLAYARGQ AMNIEAPRLP DDPIIVEDDD
     ESEEIEAESD EEEDKSGMES LKNIPQTLPY NPTVYGRPAV FDRKSDAKST KKCRAILTDF
     SVIKAIEEEH RKKKAARTEQ PRATPESQAP TVVLQRPPTQ HEPGPAGPLS VQARLEPWQP
     LPGPQVTTVL LHEESMQGVQ VHGSMLDLLE KDDEVMEQRV MATLLPPVPQ QPQAGRRGPC
     VYTGDLGIES DELASTEPVH DQLLPAPGPD PLEIQPLTSP TTSQLSSSAP SCAQTPWPVV
     QPSQTPDDPM KQSRPPETAA PRQWPMPLRP IPMRPLRMQP IPFNHPVGPT PHQTPQVELT
     PYKPTWAQMG HIPYQPTPTG PATMLLRQWA PATMQTPPRA PTPMSPPEVP PVPRQRSRGA
     PTPTPPPQVP PVPRQRPRGA PTPTPPPQVL PTPMQLAPRA PAGQQGPTKQ ILRQLLTGGV
     KKGRPSLKLQ AALERQAAAG WQPSTGSGTS AKIVRAPVFY PPVLQPIQVM GQGGSPTAMA
     ASTVTQEPTE YTRERRGVGP MPPTDIPPSK RAKIEAYTEP EMPHGGASHS PVVILENVGQ
     GQQQTLECGG TAKQERDVLG LGDIAVSSPS SSETSNDE