ID   EBNA5_EBVA8             Reviewed;         506 AA.
AC   Q1HVI8;
DT   26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2006, sequence version 1.
DT   29-SEP-2021, entry version 44.
DE   RecName: Full=Epstein-Barr nuclear antigen leader protein;
DE            Short=EBNA-LP;
DE            Short=EBV nuclear antigen leader protein;
DE   AltName: Full=Epstein-Barr nuclear antigen 5;
DE            Short=EBNA-5;
DE            Short=EBV nuclear antigen 5;
GN   Name=EBNA-LP; Synonyms=EBNA5;
OS   Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus.
OX   NCBI_TaxID=82830;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16490228; DOI=10.1016/j.virol.2006.01.015;
RA   Dolan A., Addison C., Gatherer D., Davison A.J., McGeoch D.J.;
RT   "The genome of Epstein-Barr virus type 2 strain AG876.";
RL   Virology 350:164-170(2006).
CC   -!- FUNCTION: Plays an important role in the establishment of B-cell
CC       immortalization by acting as an EBNA2 coactivator. This transcriptional
CC       activation preferentially enhances the expression of the major viral
CC       protein LMP1. The interaction between EBNA-LP and host SP100 correlates
CC       with coactivation of EBNA2 and the relocalization of SP100 from PML
CC       nuclear bodies into nucleoplasm (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homooligomer. Interacts with host SP100; this interaction is
CC       important for EBNA-LP coactivator activity. Interacts with host HAX1,
CC       ERR1 and HSPA2. Interacts with host PRKDC and AKAP8L; these
CC       interactions modulate the coactivator function of EBNA-LP (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000250}.
CC   -!- PTM: Phosphorylated by the cellular protein kinase cdc2. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the lymphocryptovirus EBNA-LP family.
CC       {ECO:0000305}.
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DR   EMBL; DQ279927; ABB89221.1; -; Genomic_DNA.
DR   RefSeq; YP_001129440.1; NC_009334.1.
DR   PRIDE; Q1HVI8; -.
DR   GeneID; 5176191; -.
DR   KEGG; vg:5176191; -.
DR   Proteomes; UP000007639; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR005030; Herpes_LP.
DR   Pfam; PF03363; Herpes_LP; 6.
PE   3: Inferred from homology;
KW   Activator; Host nucleus; Host-virus interaction; Phosphoprotein;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..506
FT                   /note="Epstein-Barr nuclear antigen leader protein"
FT                   /id="PRO_0000376061"
FT   REGION          1..471
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        35..54
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        101..120
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        167..186
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        233..252
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        299..318
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        365..384
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        431..450
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         35
FT                   /note="Phosphoserine; by host"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   506 AA;  54751 MW;  81E6D7AF1E773998 CRC64;
     MGDRSEVPGP ARPGPPGIGP EGPLGQLLRR HRSPSPTRGG QEPRRVRRRV LVQQEEEVVS
     GSPSGPRGDR SEVPGPARPG PPGIGPEGPL GQLLRRHRSP SPTRGGQEPR RVRRRVLVQQ
     EEEVVSGSPS GPRGDRSEVP GPARPGPPGI GPEGPLGQLL RRHRSPSPTR GGQEPRRVRR
     RVLVQQEEEV VSGSPSGPRG DRSEVPGPAR PGPPGIGPEG PLGQLLRRHR SPSPTRGGQE
     PRRVRRRVLV QQEEEVVSGS PSGPRGDRSE VPGPARPGPP GIGPEGPLGQ LLRRHRSPSP
     TRGGQEPRRV RRRVLVQQEE EVVSGSPSGP RGDRSEVPGP ARPGPPGIGP EGPLGQLLRR
     HRSPSPTRGG QEPRRVRRRV LVQQEEEVVS GSPSGPRGDR SEVPGPARPG PPGIGPEGPL
     GQLLRRHRSP SPTRGGQEPR RVRRRVLVQQ EEEVVSGSPS GPLRPRPQPP AQSLREWLLR
     ISERFDPHPV ATRRQSVYIE EEEDED