ID   EBNA5_EBVG              Reviewed;         506 AA.
AC   P0C732;
DT   26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-MAY-2009, sequence version 1.
DT   29-SEP-2021, entry version 44.
DE   RecName: Full=Epstein-Barr nuclear antigen leader protein;
DE            Short=EBNA-LP;
DE            Short=EBV nuclear antigen leader protein;
DE   AltName: Full=Epstein-Barr nuclear antigen 5;
DE            Short=EBNA-5;
DE            Short=EBV nuclear antigen 5;
GN   Name=EBNA-LP; Synonyms=EBNA5;
OS   Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus.
OX   NCBI_TaxID=10376;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16306603; DOI=10.1128/jvi.79.24.15323-15330.2005;
RA   Zeng M.-S., Li D.-J., Liu Q.-L., Song L.-B., Li M.-Z., Zhang R.-H.,
RA   Yu X.-J., Wang H.-M., Ernberg I., Zeng Y.-X.;
RT   "Genomic sequence analysis of Epstein-Barr virus strain GD1 from a
RT   nasopharyngeal carcinoma patient.";
RL   J. Virol. 79:15323-15330(2005).
CC   -!- FUNCTION: Plays an important role in the establishment of B-cell
CC       immortalization by acting as an EBNA2 coactivator. This transcriptional
CC       activation preferentially enhances the expression of the major viral
CC       protein LMP1. The interaction between EBNA-LP and host SP100 correlates
CC       with coactivation of EBNA2 and the relocalization of SP100 from PML
CC       nuclear bodies into nucleoplasm (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homooligomer. Interacts with host SP100; this interaction is
CC       important for EBNA-LP coactivator activity. Interacts with host HAX1,
CC       ERR1 and HSPA2. Interacts with host PRKDC and AKAP8L; these
CC       interactions modulate the coactivator function of EBNA-LP (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000250}.
CC   -!- PTM: Phosphorylated by the cellular protein kinase cdc2. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the lymphocryptovirus EBNA-LP family.
CC       {ECO:0000305}.
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DR   EMBL; AY961628; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; YP_401636.1; NC_007605.1.
DR   SMR; P0C732; -.
DR   BioGRID; 971788; 154.
DR   IntAct; P0C732; 1.
DR   DNASU; 3783746; -.
DR   GeneID; 3783746; -.
DR   KEGG; vg:3783746; -.
DR   Proteomes; UP000007641; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR005030; Herpes_LP.
DR   Pfam; PF03363; Herpes_LP; 6.
PE   3: Inferred from homology;
KW   Activator; Host nucleus; Host-virus interaction; Phosphoprotein;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..506
FT                   /note="Epstein-Barr nuclear antigen leader protein"
FT                   /id="PRO_0000376062"
FT   REGION          1..470
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          485..506
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        35..54
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        101..120
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        167..186
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        233..252
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        299..318
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        365..384
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        431..450
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         35
FT                   /note="Phosphoserine; by host"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   506 AA;  54739 MW;  CD2C6C3B737AC1E9 CRC64;
     MGDRSEGPGP TRPGPPGIGP EGPLGQLLRR HRSPSPTRGG QEPRRVRRRV LVQQEEEVVS
     GSPSGPRGDR SEGPGPTRPG PPGIGPEGPL GQLLRRHRSP SPTRGGQEPR RVRRRVLVQQ
     EEEVVSGSPS GPRGDRSEGP GPTRPGPPGI GPEGPLGQLL RRHRSPSPTR GGQEPRRVRR
     RVLVQQEEEV VSGSPSGPRG DRSEGPGPTR PGPPGIGPEG PLGQLLRRHR SPSPTRGGQE
     PRRVRRRVLV QQEEEVVSGS PSGPRGDRSE GPGPTRPGPP GIGPEGPLGQ LLRRHRSPSP
     TRGGQEPRRV RRRVLVQQEE EVVSGSPSGP RGDRSEGPGP TRPGPPGIGP EGPLGQLLRR
     HRSPSPTRGG QEPRRVRRRV LVQQEEEVVS GSPSGPRGDR SEGPGPTRPG PPGIGPEGPL
     GQLLRRHRSP SPTRGGQEPR RVRRRVLVQQ EEEVVSGSPS GPLRPRPRPP ARSLREWLLR
     IRDHFEPPTV TTQRQSVYIE EEEDED