EBP2_ARATH
ID EBP2_ARATH Reviewed; 293 AA.
AC Q9LUJ5;
DT 06-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Probable rRNA-processing protein EBP2 homolog;
GN Name=EBP2 {ECO:0000305}; OrderedLocusNames=At3g22660; ORFNames=MWI23.3;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:131-135(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP FUNCTION, INTERACTION WITH NSN1, AND SUBCELLULAR LOCATION.
RX PubMed=26163696; DOI=10.1093/jxb/erv337;
RA Jeon Y., Park Y.J., Cho H.K., Jung H.J., Ahn T.K., Kang H., Pai H.S.;
RT "The nucleolar GTPase nucleostemin-like 1 plays a role in plant growth and
RT senescence by modulating ribosome biogenesis.";
RL J. Exp. Bot. 66:6297-6310(2015).
CC -!- FUNCTION: Required for the processing of the 27S pre-rRNA (By
CC similarity). Plays an important role in plant growth and senescence by
CC modulating ribosome biogenesis in nucleolus. Associates with ribosomes
CC (PubMed:26163696). {ECO:0000250|UniProtKB:P36049,
CC ECO:0000269|PubMed:26163696}.
CC -!- SUBUNIT: Interacts with NSN1. {ECO:0000269|PubMed:26163696}.
CC -!- INTERACTION:
CC Q9LUJ5; Q9LQW3: ZHD14; NbExp=3; IntAct=EBI-25515709, EBI-1806701;
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:26163696}.
CC -!- SIMILARITY: Belongs to the EBP2 family. {ECO:0000305}.
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DR EMBL; AB022223; BAB01241.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE76662.1; -; Genomic_DNA.
DR EMBL; AY058884; AAL24270.1; -; mRNA.
DR EMBL; BT001010; AAN46764.1; -; mRNA.
DR RefSeq; NP_188905.1; NM_113165.4.
DR AlphaFoldDB; Q9LUJ5; -.
DR SMR; Q9LUJ5; -.
DR BioGRID; 7169; 2.
DR IntAct; Q9LUJ5; 1.
DR STRING; 3702.AT3G22660.1; -.
DR PaxDb; Q9LUJ5; -.
DR PRIDE; Q9LUJ5; -.
DR ProteomicsDB; 224712; -.
DR EnsemblPlants; AT3G22660.1; AT3G22660.1; AT3G22660.
DR GeneID; 821837; -.
DR Gramene; AT3G22660.1; AT3G22660.1; AT3G22660.
DR KEGG; ath:AT3G22660; -.
DR Araport; AT3G22660; -.
DR TAIR; locus:2094384; AT3G22660.
DR eggNOG; KOG3080; Eukaryota.
DR HOGENOM; CLU_036007_4_0_1; -.
DR InParanoid; Q9LUJ5; -.
DR OMA; MFHRQAQ; -.
DR OrthoDB; 1154126at2759; -.
DR PhylomeDB; Q9LUJ5; -.
DR PRO; PR:Q9LUJ5; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LUJ5; baseline and differential.
DR Genevisible; Q9LUJ5; AT.
DR GO; GO:0034399; C:nuclear periphery; IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; IDA:UniProtKB.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR GO; GO:0003924; F:GTPase activity; IDA:UniProtKB.
DR GO; GO:0003723; F:RNA binding; IDA:UniProtKB.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; IMP:UniProtKB.
DR GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR InterPro; IPR008610; Ebp2.
DR PANTHER; PTHR13028; PTHR13028; 1.
DR Pfam; PF05890; Ebp2; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Nucleus; Reference proteome; Ribosome biogenesis.
FT CHAIN 1..293
FT /note="Probable rRNA-processing protein EBP2 homolog"
FT /id="PRO_0000119998"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 150..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 135..190
FT /evidence="ECO:0000255"
FT COMPBIAS 1..33
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 150..219
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 243..260
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 293 AA; 33206 MW; 5EDEDEACABAF86D8 CRC64;
MSLEEDIVSD DEMNMIDEDD ATDSEAESLS DSDTENEITE KLAEPTKTAI YNRDGLLDKL
QDISWPEDVD WTHKLTVEID QGGAVDVNDD LARETAFYTQ ALEGTREAFG KLNEMGVNFL
RPANYYAEMV KSDVHMEKVK SRLLHEKKQI EESEERRKAR DNKRMAKEVQ SQKMKERAKE
KKDNIESVKK WRKQRQQSGF SDKAGEPELD FESGKSFQRG GGKKRPGVSP GDRSGGKGRP
TSRMGNKKRE FRDSKFGHGG RKGLSKQNTA ETTNDFKGGF RGGKASGNKR QKR
