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EBP2_CAEEL
ID   EBP2_CAEEL              Reviewed;         340 AA.
AC   Q09958;
DT   06-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 2.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Probable rRNA-processing protein EBP2 homolog;
GN   ORFNames=C18A3.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Required for the processing of the 27S pre-rRNA.
CC       {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q09958; Q11184: let-756; NbExp=2; IntAct=EBI-2412471, EBI-3843983;
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EBP2 family. {ECO:0000305}.
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DR   EMBL; FO080599; CCD65011.1; -; Genomic_DNA.
DR   PIR; T15543; T15543.
DR   RefSeq; NP_495125.1; NM_062724.4.
DR   AlphaFoldDB; Q09958; -.
DR   SMR; Q09958; -.
DR   BioGRID; 39310; 15.
DR   IntAct; Q09958; 2.
DR   STRING; 6239.C18A3.3; -.
DR   EPD; Q09958; -.
DR   PaxDb; Q09958; -.
DR   PeptideAtlas; Q09958; -.
DR   EnsemblMetazoa; C18A3.3.1; C18A3.3.1; WBGene00015941.
DR   GeneID; 173968; -.
DR   KEGG; cel:CELE_C18A3.3; -.
DR   UCSC; C18A3.3; c. elegans.
DR   CTD; 173968; -.
DR   WormBase; C18A3.3; CE28890; WBGene00015941; -.
DR   eggNOG; KOG3080; Eukaryota.
DR   GeneTree; ENSGT00390000014984; -.
DR   HOGENOM; CLU_036007_1_0_1; -.
DR   InParanoid; Q09958; -.
DR   OMA; MFHRQAQ; -.
DR   OrthoDB; 1154126at2759; -.
DR   PhylomeDB; Q09958; -.
DR   Reactome; R-CEL-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   PRO; PR:Q09958; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00015941; Expressed in adult organism and 4 other tissues.
DR   GO; GO:0034399; C:nuclear periphery; IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR   InterPro; IPR008610; Ebp2.
DR   PANTHER; PTHR13028; PTHR13028; 1.
DR   Pfam; PF05890; Ebp2; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Nucleus; Reference proteome; Ribosome biogenesis.
FT   CHAIN           1..340
FT                   /note="Probable rRNA-processing protein EBP2 homolog"
FT                   /id="PRO_0000119996"
FT   REGION          1..59
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          245..340
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          206..245
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        45..59
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        281..308
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   340 AA;  38083 MW;  13EE225D985A5D55 CRC64;
     MVRKMNKLAK RLASTSKSRQ PEPESDSDGS EFDFDNAIEE KPMEAMDIEE VESDGDDDER
     ELQAAFAAGL LKDGLNIQVA KKRPIINKSA EMKEKLAEIT KDLPWVETLE VVTPHSEMDK
     KVENDDFQRE LNFYKQAEKA VQIAYPRLLN LGIKVLRPTD YYAEMAKSDT HMQKVRKRLL
     GIQEMKERQE AFRRIREEKK FAVKVQKEVL AAKNTEKKNL AEAVKKHKKG MKQQLEDMLN
     NVKRHGLDQD DDAPTGAFGD RLGGRGGAGR GGAGRGGSMR NAGELKRKLK SDKFGYGGKK
     KGMKRNNKES FNDLFGAPRG GFGGRGRGGG RGGRGGRGRR
 
 
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