EBR_SALTM
ID EBR_SALTM Reviewed; 115 AA.
AC P0AA23; P14502;
DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 1.
DT 03-AUG-2022, entry version 77.
DE RecName: Full=Putative ethidium bromide resistance protein;
DE AltName: Full=E1 protein;
GN Name=ebr; Synonyms=E1;
OS Salmonella typhimurium.
OG Plasmid IncN R46.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=90371;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2560119; DOI=10.1111/j.1365-2958.1989.tb00153.x;
RA Stokes H.W., Hall R.M.;
RT "A novel family of potentially mobile DNA elements encoding site-specific
RT gene-integration functions: integrons.";
RL Mol. Microbiol. 3:1669-1683(1989).
CC -!- FUNCTION: One of the determinants for resistance to ethidium bromide
CC and quaternary ammonium compounds. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
CC {ECO:0000305}.
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DR EMBL; M95287; AAB59086.1; -; Genomic_DNA.
DR PIR; S07656; S07656.
DR RefSeq; NP_511227.1; NC_003292.1.
DR RefSeq; WP_000679427.1; NZ_WIDG01000069.1.
DR RefSeq; YP_003264406.1; NC_013437.1.
DR RefSeq; YP_006955544.1; NC_019001.1.
DR AlphaFoldDB; P0AA23; -.
DR SMR; P0AA23; -.
DR GeneID; 67375552; -.
DR eggNOG; COG2076; Bacteria.
DR OMA; EGFTQAW; -.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR InterPro; IPR000390; Small_drug/metabolite_transptr.
DR InterPro; IPR045324; Small_multidrug_res.
DR PANTHER; PTHR30561; PTHR30561; 1.
DR Pfam; PF00893; Multi_Drug_Res; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Plasmid; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..115
FT /note="Putative ethidium bromide resistance protein"
FT /id="PRO_0000108072"
FT TRANSMEM 4..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 30..47
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 85..104
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 115 AA; 12332 MW; 1676BE6C66759B5E CRC64;
MKGWLFLVIA IVGEVIATSA LKSSEGFTKL APSAVVIIGY GIAFYFLSLV LKSIPVGVAY
AVWSGLGVVI ITAIAWLLHG QKLDAWGFVG MGLIIAAFLL ARSPSWKSLR RPTPW