ID   ECC1A_MYCTO             Reviewed;         747 AA.
AC   P9WNB2; L0TE12; O69735; Q7D4P6;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 38.
DE   RecName: Full=ESX-1 secretion system protein EccCa1 {ECO:0000250|UniProtKB:P9WNB3};
DE   AltName: Full=ESX conserved component Ca1 {ECO:0000250|UniProtKB:P9WNB3};
DE   AltName: Full=Type VII secretion system protein EccCa1 {ECO:0000250|UniProtKB:P9WNB3};
DE            Short=T7SS protein EccCa1 {ECO:0000250|UniProtKB:P9WNB3};
GN   Name=eccCa1 {ECO:0000250|UniProtKB:P9WNB3}; Synonyms=snm1;
GN   OrderedLocusNames=MT3983;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Part of the ESX-1 specialized secretion system, which
CC       delivers several virulence factors to host cells during infection,
CC       including the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10).
CC       {ECO:0000250|UniProtKB:P9WNB3}.
CC   -!- SUBUNIT: Part of the ESX-1 / type VII secretion system (T7SS), which is
CC       composed of cytosolic and membrane components. The ESX-1 membrane
CC       complex is composed of EccB1, EccCa1, EccCb1, EccD1 and EccE1.
CC       {ECO:0000250|UniProtKB:P9WNB3}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000250|UniProtKB:P9WNB3}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- MISCELLANEOUS: In ESX-1 cluster, the FtsK/SpoIIIE-like protein is split
CC       in two genes. {ECO:0000305}.
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DR   EMBL; AE000516; AAK48351.1; -; Genomic_DNA.
DR   PIR; D70802; D70802.
DR   RefSeq; WP_003899738.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WNB2; -.
DR   SMR; P9WNB2; -.
DR   EnsemblBacteria; AAK48351; AAK48351; MT3983.
DR   GeneID; 45427874; -.
DR   KEGG; mtc:MT3983; -.
DR   PATRIC; fig|83331.31.peg.4285; -.
DR   HOGENOM; CLU_003134_1_1_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR023836; EccCa-like_Actinobacteria.
DR   InterPro; IPR002543; FtsK_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF01580; FtsK_SpoIIIE; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR03924; T7SS_EccC_a; 1.
DR   PROSITE; PS50901; FTSK; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell inner membrane; Cell membrane; Membrane;
KW   Nucleotide-binding; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..747
FT                   /note="ESX-1 secretion system protein EccCa1"
FT                   /id="PRO_0000427157"
FT   TRANSMEM        41..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        65..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        222..242
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          456..665
FT                   /note="FtsK"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00289"
FT   BINDING         479..486
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00289"
SQ   SEQUENCE   747 AA;  80913 MW;  CF6AA9153BE6F41E CRC64;
     MTTKKFTPTI TRGPRLTPGE ISLTPPDDLG IDIPPSGVQK ILPYVMGGAM LGMIAIMVAG
     GTRQLSPYML MMPLMMIVMM VGGLAGSTGG GGKKVPEINA DRKEYLRYLA GLRTRVTSSA
     TSQVAFFSYH APHPEDLLSI VGTQRQWSRP ANADFYAATR IGIGDQPAVD RLLKPAVGGE
     LAAASAAPQP FLEPVSHMWV VKFLRTHGLI HDCPKLLQLR TFPTIAIGGD LAGAAGLMTA
     MICHLAVFHP PDLLQIRVLT EEPDDPDWSW LKWLPHVQHQ TETDAAGSTR LIFTRQEGLS
     DLAARGPHAP DSLPGGPYVV VVDLTGGKAG FPPDGRAGVT VITLGNHRGS AYRIRVHEDG
     TADDRLPNQS FRQVTSVTDR MSPQQASRIA RKLAGWSITG TILDKTSRVQ KKVATDWHQL
     VGAQSVEEIT PSRWRMYTDT DRDRLKIPFG HELKTGNVMY LDIKEGAEFG AGPHGMLIGT
     TGSGKSEFLR TLILSLVAMT HPDQVNLLLT DFKGGSTFLG MEKLPHTAAV VTNMAEEAEL
     VSRMGEVLTG ELDRRQSILR QAGMKVGAAG ALSGVAEYEK YRERGADLPP LPTLFVVVDE
     FAELLQSHPD FIGLFDRICR VGRSLRVHLL LATQSLQTGG VRIDKLEPNL TYRIALRTTS
     SHESKAVIGT PEAQYITNKE SGVGFLRVGM EDPVKFSTFY ISGPYMPPAA GVETNGEAGG
     PGQQTTRQAA RIHRFTAAPV LEEAPTP