ID   ECC1B_MYCTO             Reviewed;         591 AA.
AC   P9WNB0; L0TGZ9; O69736; Q7D4P5;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 35.
DE   RecName: Full=ESX-1 secretion system protein EccCb1 {ECO:0000250|UniProtKB:P9WNB1};
DE   AltName: Full=ESX conserved component Cb1 {ECO:0000250|UniProtKB:P9WNB1};
DE   AltName: Full=Type VII secretion system protein EccCb1 {ECO:0000250|UniProtKB:P9WNB1};
DE            Short=T7SS protein EccCb1 {ECO:0000250|UniProtKB:P9WNB1};
GN   Name=eccCb1 {ECO:0000250|UniProtKB:P9WNB1}; Synonyms=snm2;
GN   OrderedLocusNames=MT3985;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Part of the ESX-1 specialized secretion system, which
CC       delivers several virulence factors to host cells during infection,
CC       including the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10).
CC       EccCb1 may link the cytosolic components of the system with the
CC       membrane components. {ECO:0000250|UniProtKB:P9WNB1}.
CC   -!- SUBUNIT: Part of the ESX-1 / type VII secretion system (T7SS), which is
CC       composed of cytosolic and membrane components. The ESX-1 membrane
CC       complex is composed of EccB1, EccCa1, EccCb1, EccD1 and EccE1.
CC       {ECO:0000250|UniProtKB:P9WNB1}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P9WNB1}.
CC   -!- MISCELLANEOUS: In ESX-1 cluster, the FtsK/SpoIIIE-like protein is split
CC       in two genes. {ECO:0000305}.
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DR   EMBL; AE000516; AAK48353.1; -; Genomic_DNA.
DR   PIR; E70802; E70802.
DR   RefSeq; WP_003399865.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WNB0; -.
DR   SMR; P9WNB0; -.
DR   EnsemblBacteria; AAK48353; AAK48353; MT3985.
DR   KEGG; mtc:MT3985; -.
DR   PATRIC; fig|83331.31.peg.4287; -.
DR   HOGENOM; CLU_003134_0_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR023837; EccCb-like_Actinobacteria.
DR   InterPro; IPR002543; FtsK_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF01580; FtsK_SpoIIIE; 2.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   TIGRFAMs; TIGR03925; T7SS_EccC_b; 1.
DR   PROSITE; PS50901; FTSK; 2.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; Nucleotide-binding; Repeat.
FT   CHAIN           1..591
FT                   /note="ESX-1 secretion system protein EccCb1"
FT                   /id="PRO_0000427158"
FT   DOMAIN          65..259
FT                   /note="FtsK 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00289"
FT   DOMAIN          359..545
FT                   /note="FtsK 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00289"
FT   BINDING         84..91
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00289"
FT   BINDING         376..383
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00289"
SQ   SEQUENCE   591 AA;  64561 MW;  7CD309E881A9739D CRC64;
     MTAEPEVRTL REVVLDQLGT AESRAYKMWL PPLTNPVPLN ELIARDRRQP LRFALGIMDE
     PRRHLQDVWG VDVSGAGGNI GIGGAPQTGK STLLQTMVMS AAATHSPRNV QFYCIDLGGG
     GLIYLENLPH VGGVANRSEP DKVNRVVAEM QAVMRQRETT FKEHRVGSIG MYRQLRDDPS
     QPVASDPYGD VFLIIDGWPG FVGEFPDLEG QVQDLAAQGL AFGVHVIIST PRWTELKSRV
     RDYLGTKIEF RLGDVNETQI DRITREIPAN RPGRAVSMEK HHLMIGVPRF DGVHSADNLV
     EAITAGVTQI ASQHTEQAPP VRVLPERIHL HELDPNPPGP ESDYRTRWEI PIGLRETDLT
     PAHCHMHTNP HLLIFGAAKS GKTTIAHAIA RAICARNSPQ QVRFMLADYR SGLLDAVPDT
     HLLGAGAINR NSASLDEAVQ ALAVNLKKRL PPTDLTTAQL RSRSWWSGFD VVLLVDDWHM
     IVGAAGGMPP MAPLAPLLPA AADIGLHIIV TCQMSQAYKA TMDKFVGAAF GSGAPTMFLS
     GEKQEFPSSE FKVKRRPPGQ AFLVSPDGKE VIQAPYIEPP EEVFAAPPSA G