ID   ECCA1_MYCTO             Reviewed;         573 AA.
AC   P9WPH8; L0TFH7; O69733;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 37.
DE   RecName: Full=ESX-1 secretion system protein EccA1 {ECO:0000250|UniProtKB:P9WPH9};
DE   AltName: Full=ESX conserved component A1 {ECO:0000250|UniProtKB:P9WPH9};
DE   AltName: Full=Type VII secretion system protein EccA1 {ECO:0000250|UniProtKB:P9WPH9};
DE            Short=T7SS protein EccA1 {ECO:0000250|UniProtKB:P9WPH9};
GN   Name=eccA1 {ECO:0000250|UniProtKB:P9WPH9}; OrderedLocusNames=MT3981;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Part of the ESX-1 specialized secretion system, which
CC       delivers several virulence factors to host cells during infection,
CC       including the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10).
CC       EccA1 exhibits ATPase activity and may provide energy for the export of
CC       ESX-1 substrates. {ECO:0000250|UniProtKB:P9WPH9}.
CC   -!- SUBUNIT: Part of the ESX-1 / type VII secretion system (T7SS), which is
CC       composed of cytosolic and membrane components.
CC       {ECO:0000250|UniProtKB:P9WPH9}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P9WPH9}.
CC   -!- SIMILARITY: Belongs to the CbxX/CfxQ family. {ECO:0000305}.
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DR   EMBL; AE000516; AAK48349.1; -; Genomic_DNA.
DR   PIR; B70802; B70802.
DR   RefSeq; WP_003399850.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WPH8; -.
DR   SMR; P9WPH8; -.
DR   PRIDE; P9WPH8; -.
DR   EnsemblBacteria; AAK48349; AAK48349; MT3981.
DR   KEGG; mtc:MT3981; -.
DR   PATRIC; fig|83331.31.peg.4283; -.
DR   HOGENOM; CLU_008749_5_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   Gene3D; 1.25.40.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR041627; AAA_lid_6.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR000641; CbxX/CfxQ.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR023835; T7SS_EccA.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF17866; AAA_lid_6; 1.
DR   PRINTS; PR00819; CBXCFQXSUPER.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR03922; T7SS_EccA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; Nucleotide-binding.
FT   CHAIN           1..573
FT                   /note="ESX-1 secretion system protein EccA1"
FT                   /id="PRO_0000426949"
FT   BINDING         334..341
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   573 AA;  62426 MW;  58D4751E2D9F19EA CRC64;
     MTDRLASLFE SAVSMLPMSE ARSLDLFTEI TNYDESACDA WIGRIRCGDT DRVTLFRAWY
     SRRNFGQLSG SVQISMSTLN ARIAIGGLYG DITYPVTSPL AITMGFAACE AAQGNYADAM
     EALEAAPVAG SEHLVAWMKA VVYGAAERWT DVIDQVKSAG KWPDKFLAGA AGVAHGVAAA
     NLALFTEAER RLTEANDSPA GEACARAIAW YLAMARRSQG NESAAVALLE WLQTTHPEPK
     VAAALKDPSY RLKTTTAEQI ASRADPWDPG SVVTDNSGRE RLLAEAQAEL DRQIGLTRVK
     NQIERYRAAT LMARVRAAKG MKVAQPSKHM IFTGPPGTGK TTIARVVANI LAGLGVIAEP
     KLVETSRKDF VAEYEGQSAV KTAKTIDQAL GGVLFIDEAY ALVQERDGRT DPFGQEALDT
     LLARMENDRD RLVVIIAGYS SDIDRLLETN EGLRSRFATR IEFDTYSPEE LLEIANVIAA
     ADDSALTAEA AENFLQAAKQ LEQRMLRGRR ALDVAGNGRY ARQLVEASEQ CRDMRLAQVL
     DIDTLDEDRL REINGSDMAE AIAAVHAHLN MRE