ID   ECCA3_MYCLE             Reviewed;         640 AA.
AC   Q9CD28;
DT   14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=ESX-3 secretion system protein EccA3 {ECO:0000305};
DE   AltName: Full=ESX conserved component A3 {ECO:0000303|PubMed:19876390};
DE   AltName: Full=Type VII secretion system protein EccA3 {ECO:0000305};
DE            Short=T7SS protein EccA3 {ECO:0000305};
GN   Name=eccA3 {ECO:0000303|PubMed:19876390}; OrderedLocusNames=ML2537;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=19876390; DOI=10.1371/journal.ppat.1000507;
RA   Bitter W., Houben E.N., Bottai D., Brodin P., Brown E.J., Cox J.S.,
RA   Derbyshire K., Fortune S.M., Gao L.Y., Liu J., Gey van Pittius N.C.,
RA   Pym A.S., Rubin E.J., Sherman D.R., Cole S.T., Brosch R.;
RT   "Systematic genetic nomenclature for type VII secretion systems.";
RL   PLoS Pathog. 5:E1000507-E1000507(2009).
CC   -!- FUNCTION: Part of an ESX-3 / type VII specialized secretion system
CC       (T7SS), which exports several proteins. EccA3 exhibits ATPase activity
CC       and may provide energy for the export of ESX-3 substrates (By
CC       similarity). {ECO:0000250|UniProtKB:P9WPH9}.
CC   -!- SUBUNIT: Part of the ESX-3 / type VII secretion system (T7SS), which is
CC       composed of cytosolic and membrane components (By similarity).
CC       {ECO:0000250|UniProtKB:P9WPH9}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:B2HSU9}.
CC   -!- SIMILARITY: Belongs to the CbxX/CfxQ family. {ECO:0000305}.
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DR   EMBL; AL583926; CAC32068.1; -; Genomic_DNA.
DR   PIR; F87226; F87226.
DR   RefSeq; NP_302631.1; NC_002677.1.
DR   RefSeq; WP_010908950.1; NC_002677.1.
DR   AlphaFoldDB; Q9CD28; -.
DR   SMR; Q9CD28; -.
DR   STRING; 272631.ML2537; -.
DR   EnsemblBacteria; CAC32068; CAC32068; CAC32068.
DR   KEGG; mle:ML2537; -.
DR   PATRIC; fig|272631.5.peg.4869; -.
DR   Leproma; ML2537; -.
DR   eggNOG; COG0464; Bacteria.
DR   HOGENOM; CLU_008749_5_0_11; -.
DR   OMA; AHEQCDA; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   Gene3D; 1.25.40.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR041627; AAA_lid_6.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR000641; CbxX/CfxQ.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR023835; T7SS_EccA.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF17866; AAA_lid_6; 1.
DR   PRINTS; PR00819; CBXCFQXSUPER.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR03922; T7SS_EccA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..640
FT                   /note="ESX-3 secretion system protein EccA3"
FT                   /id="PRO_0000063044"
FT   BINDING         393..400
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   640 AA;  69057 MW;  CA61044B77F1D77A CRC64;
     MLISGRSGWA ILGTGGKAAV NRGDAGKLGG QSVIARAHVK VDGDVVSRFA TCCRALGLAV
     YDRQRPADLA AARSGFTALA RIAHDQCDVW IGLAAAGDVS TPVLAAISCT ADTAGMLQRQ
     VELAPAALGF HYDTGLYLQF RAIGPDDFHL AYAASLASTG GPGPYAEADQ IVTGIIDRRP
     GWRDARWVAA VIHYRAGRWS DVVKLLTPIV NDPDIDEAYT HAAKIALGTA LARLGMFAPA
     LSYLEEPAGP VAVAAVDGAL AKALVLRAHT DEESASEVLQ DLYAAHPDNE QIEQALSDTS
     FGIVTTTAAR IDARTDPWDP ETEPGVEDFI DPAAHERKAV LLHEAERQLA EFIGLDEVKN
     QVSRLKSSVA MELVRKQRGL MVAQRAHHLV FAGPPGTGKT TIARVVAKVY CGLGLLKKEN
     IREVHRADLI GQHIGETEAK TNAVIDSALD GVLFLDEAYA LVATGAKNDF GLVAIDTLLA
     RMENDRDRLV VIIAGYRADL DKFLDTNEGL RSRFTRNIDF PSYASHELVE IAHKMAEQRD
     SVFEQAALDE LEVLFANLAT SSTPDSNGIS RRSLDIAGNG RFVRNIVERS EEEREFRLDH
     SNNVGTGELS DEELMTVTSE DVRRSVEPLL RGLGLMVPHD