ID   ECCA5_MYCTO             Reviewed;         610 AA.
AC   P9WPI0; L0TAM8; O53947; P63744;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 41.
DE   RecName: Full=ESX-5 secretion system protein EccA5 {ECO:0000250|UniProtKB:P9WPI1};
DE   AltName: Full=ESX conserved component A5 {ECO:0000250|UniProtKB:P9WPI1};
DE   AltName: Full=Type VII secretion system protein EccA5 {ECO:0000250|UniProtKB:P9WPI1};
DE            Short=T7SS protein EccA5 {ECO:0000250|UniProtKB:P9WPI1};
GN   Name=eccA5 {ECO:0000250|UniProtKB:P9WPI1}; OrderedLocusNames=MT1847;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Part of the ESX-5 specialized secretion system, which is
CC       responsible for the secretion of EsxN and a number of PE_PGRS and PPE
CC       proteins, including PPE41 (By similarity). EccA5 exhibits ATPase
CC       activity and may provide energy for the export of ESX-5 substrates (By
CC       similarity). {ECO:0000250|UniProtKB:P9WPH9,
CC       ECO:0000250|UniProtKB:P9WPI1}.
CC   -!- SUBUNIT: Part of the ESX-5 / type VII secretion system (T7SS), which is
CC       composed of cytosolic and membrane components.
CC       {ECO:0000250|UniProtKB:P9WPH9}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:B2HSU9}.
CC   -!- SIMILARITY: Belongs to the CbxX/CfxQ family. {ECO:0000305}.
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DR   EMBL; AE000516; AAK46118.1; -; Genomic_DNA.
DR   PIR; G70930; G70930.
DR   RefSeq; WP_003408868.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WPI0; -.
DR   SMR; P9WPI0; -.
DR   EnsemblBacteria; AAK46118; AAK46118; MT1847.
DR   GeneID; 45425775; -.
DR   KEGG; mtc:MT1847; -.
DR   PATRIC; fig|83331.31.peg.1989; -.
DR   HOGENOM; CLU_008749_5_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   Gene3D; 1.25.40.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR041627; AAA_lid_6.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR000641; CbxX/CfxQ.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR023835; T7SS_EccA.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF17866; AAA_lid_6; 1.
DR   PRINTS; PR00819; CBXCFQXSUPER.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR03922; T7SS_EccA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; Nucleotide-binding.
FT   CHAIN           1..610
FT                   /note="ESX-5 secretion system protein EccA5"
FT                   /id="PRO_0000426948"
FT   BINDING         357..364
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   610 AA;  67756 MW;  E6DE3C2D1C5356BC CRC64;
     MTRPQAAAED ARNAMVAGLL ASGISVNGLQ PSHNPQVAAQ MFTTATRLDP KMCDAWLARL
     LAGDQSIEVL AGAWAAVRTF GWETRRLGVT DLQFRPEVSD GLFLRLAITS VDSLACAYAA
     VLAEAKRYQE AAELLDATDP RHPFDAELVS YVRGVLYFRT KRWPDVLAQF PEATQWRHPE
     LKAAGAAMAT TALASLGVFE EAFRRAQEAI EGDRVPGAAN IALYTQGMCL RHVGREEEAV
     ELLRRVYSRD AKFTPAREAL DNPNFRLILT DPETIEARTD PWDPDSAPTR AQTEAARHAE
     MAAKYLAEGD AELNAMLGME QAKKEIKLIK STTKVNLARA KMGLPVPVTS RHTLLLGPPG
     TGKTSVARAF TKQLCGLTVL RKPLVVETSR TKLLGRYMAD AEKNTEEMLE GALGGAVFFD
     EMHTLHEKGY SQGDPYGNAI INTLLLYMEN HRDELVVFGA GYAKAMEKML EVNQGLRRRF
     STVIEFFSYT PQELIALTQL MGRENEDVIT EEESQVLLPS YTKFYMEQSY SEDGDLIRGI
     DLLGNAGFVR NVVEKARDHR SFRLDDEDLD AVLASDLTEF SEDQLRRFKE LTREDLAEGL
     RAAVAEKKTK