ID   ECCB1_MYCTO             Reviewed;         480 AA.
AC   P9WNR6; L0TDT4; O69734; Q7D4P7;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 38.
DE   RecName: Full=ESX-1 secretion system ATPase EccB1 {ECO:0000250|UniProtKB:P9WNR7};
DE            EC=3.6.-.- {ECO:0000305};
DE   AltName: Full=ESX conserved component B1 {ECO:0000250|UniProtKB:P9WNR7};
DE   AltName: Full=Type VII secretion system protein EccB1 {ECO:0000250|UniProtKB:P9WNR7};
DE            Short=T7SS protein EccB1 {ECO:0000250|UniProtKB:P9WNR7};
GN   Name=eccB1 {ECO:0000250|UniProtKB:P9WNR7}; OrderedLocusNames=MT3982;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: An ATPase (By similarity). Part of the ESX-1 specialized
CC       secretion system, which delivers several virulence factors to host
CC       cells during infection, including the key virulence factors EsxA (ESAT-
CC       6) and EsxB (CFP-10). {ECO:0000250|UniProtKB:P9WNR7}.
CC   -!- SUBUNIT: Part of the ESX-1 / type VII secretion system (T7SS), which is
CC       composed of cytosolic and membrane components. The ESX-1 membrane
CC       complex is composed of EccB1, EccCa1, EccCb1, EccD1 and EccE1.
CC       {ECO:0000250|UniProtKB:P9WNR7}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000250|UniProtKB:P9WNR7}; Single-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the EccB family. {ECO:0000305}.
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DR   EMBL; AE000516; AAK48350.1; -; Genomic_DNA.
DR   PIR; C70802; C70802.
DR   RefSeq; WP_003399854.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WNR6; -.
DR   SMR; P9WNR6; -.
DR   EnsemblBacteria; AAK48350; AAK48350; MT3982.
DR   KEGG; mtc:MT3982; -.
DR   PATRIC; fig|83331.31.peg.4284; -.
DR   HOGENOM; CLU_036302_3_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.50.910; -; 1.
DR   Gene3D; 3.30.2390.20; -; 1.
DR   InterPro; IPR007795; T7SS_EccB.
DR   InterPro; IPR044857; T7SS_EccB_R1.
DR   InterPro; IPR042485; T7SS_EccB_R3.
DR   PANTHER; PTHR40765; PTHR40765; 1.
DR   Pfam; PF05108; T7SS_ESX1_EccB; 1.
DR   TIGRFAMs; TIGR03919; T7SS_EccB; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell inner membrane; Cell membrane; Hydrolase; Membrane;
KW   Nucleotide-binding; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..480
FT                   /note="ESX-1 secretion system ATPase EccB1"
FT                   /id="PRO_0000427080"
FT   TRANSMEM        44..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          461..480
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   480 AA;  51093 MW;  D19CAD0FB2B9DE4A CRC64;
     MGLRLTTKVQ VSGWRFLLRR LEHAIVRRDT RMFDDPLQFY SRSIALGIVV AVLILAGAAL
     LAYFKPQGKL GGTSLFTDRA TNQLYVLLSG QLHPVYNLTS ARLVLGNPAN PATVKSSELS
     KLPMGQTVGI PGAPYATPVS AGSTSIWTLC DTVARADSTS PVVQTAVIAM PLEIDASIDP
     LQSHEAVLVS YQGETWIVTT KGRHAIDLTD RALTSSMGIP VTARPTPISE GMFNALPDMG
     PWQLPPIPAA GAPNSLGLPD DLVIGSVFQI HTDKGPQYYV VLPDGIAQVN ATTAAALRAT
     QAHGLVAPPA MVPSLVVRIA ERVYPSPLPD EPLKIVSRPQ DPALCWSWQR SAGDQSPQST
     VLSGRHLPIS PSAMNMGIKQ IHGTATVYLD GGKFVALQSP DPRYTESMYY IDPQGVRYGV
     PNAETAKSLG LSSPQNAPWE IVRLLVDGPV LSKDAALLEH DTLPADPSPR KVPAGASGAP