ECCB2_MYCTO
ID ECCB2_MYCTO Reviewed; 495 AA.
AC P9WNR4; L0TE37; O05449; Q7D4N1;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 25-MAY-2022, entry version 35.
DE RecName: Full=ESX-2 secretion system ATPase EccB2;
DE EC=3.6.-.- {ECO:0000305};
DE AltName: Full=ESX conserved component B2;
DE AltName: Full=Type VII secretion system protein EccB2;
DE Short=T7SS protein EccB2;
GN Name=eccB2; OrderedLocusNames=MT4011;
OS Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83331;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 1551 / Oshkosh;
RX PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT laboratory strains.";
RL J. Bacteriol. 184:5479-5490(2002).
CC -!- FUNCTION: An ATPase (By similarity). {ECO:0000250|UniProtKB:P9WNR7}.
CC -!- SUBUNIT: Part of the ESX-2 / type VII secretion system (T7SS), which is
CC composed of cytosolic and membrane components.
CC {ECO:0000250|UniProtKB:P9WNR7}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the EccB family. {ECO:0000305}.
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DR EMBL; AE000516; AAK48377.1; -; Genomic_DNA.
DR PIR; H70598; H70598.
DR RefSeq; WP_003400065.1; NZ_KK341228.1.
DR AlphaFoldDB; P9WNR4; -.
DR SMR; P9WNR4; -.
DR EnsemblBacteria; AAK48377; AAK48377; MT4011.
DR KEGG; mtc:MT4011; -.
DR PATRIC; fig|83331.31.peg.4318; -.
DR HOGENOM; CLU_036302_3_0_11; -.
DR Proteomes; UP000001020; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR Gene3D; 2.40.50.910; -; 1.
DR Gene3D; 3.30.2390.20; -; 1.
DR InterPro; IPR007795; T7SS_EccB.
DR InterPro; IPR044857; T7SS_EccB_R1.
DR InterPro; IPR042485; T7SS_EccB_R3.
DR PANTHER; PTHR40765; PTHR40765; 1.
DR Pfam; PF05108; T7SS_ESX1_EccB; 1.
DR TIGRFAMs; TIGR03919; T7SS_EccB; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cell membrane; Hydrolase; Membrane; Nucleotide-binding;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..495
FT /note="ESX-2 secretion system ATPase EccB2"
FT /id="PRO_0000427081"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 495 AA; 51587 MW; 24C0C414C7C1C2B5 CRC64;
MPLSLSNRDQ NSGHLFYNRR LRAATTRFSV RMKHDDRKQT AALALSMVLV AIAAGWMMLL
NVLKPTGIVG DSAIIGDRDS GALYARIDGR LYPALNLTSA RLATGTAGQP TWVKPAEIAK
YPTGPLVGIP GAPAAMPVNR GAVSAWAVCD TAGRPRSADK PVVTSIAGPI TGGGRATHLR
DDAGLLVTFD GSTYVIWGGK RSQIDPTNRA VTLSLGLDPG VTSPIQISRA LFDGLPATEP
LRVPAVPEAG TPSTWVPGAR VGSVLQAQTA GGGSQFYVLL PDGVQKISSF VADLLRSANS
YGAAAPRVVT PDVLVHTPQV TSLPVEYYPA GRLNFVDTAA DPTTCVSWEK ASTDPQARVA
VYNGRGLPVP PSMDSRIVRL VRDDRAPASV VATQVLVLPG AANFVTSTSG VITAESRESL
FWVSGNGVRF GIANDEATLR ALGLDPGAAV QAPWPLLRTF AAGPALSRDA ALLARDTVPT
LGQVAIVTTT AKAGA