ECCB5_MYCMM
ID ECCB5_MYCMM Reviewed; 507 AA.
AC B2HST3;
DT 11-NOV-2015, integrated into UniProtKB/Swiss-Prot.
DT 10-JUN-2008, sequence version 1.
DT 25-MAY-2022, entry version 54.
DE RecName: Full=ESX-5 secretion system ATPase EccB5 {ECO:0000305};
DE EC=3.6.-.- {ECO:0000305};
DE AltName: Full=ESX conserved component B5 {ECO:0000305};
DE AltName: Full=Type VII secretion system protein EccB5 {ECO:0000305};
DE Short=T7SS protein EccB5 {ECO:0000305};
GN Name=eccB5 {ECO:0000303|PubMed:22925462};
GN OrderedLocusNames=MMAR_2664 {ECO:0000312|EMBL:ACC41107.1};
OS Mycobacterium marinum (strain ATCC BAA-535 / M).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=216594;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-535 / M;
RX PubMed=18403782; DOI=10.1101/gr.075069.107;
RA Stinear T.P., Seemann T., Harrison P.F., Jenkin G.A., Davies J.K.,
RA Johnson P.D., Abdellah Z., Arrowsmith C., Chillingworth T., Churcher C.,
RA Clarke K., Cronin A., Davis P., Goodhead I., Holroyd N., Jagels K.,
RA Lord A., Moule S., Mungall K., Norbertczak H., Quail M.A.,
RA Rabbinowitsch E., Walker D., White B., Whitehead S., Small P.L., Brosch R.,
RA Ramakrishnan L., Fischbach M.A., Parkhill J., Cole S.T.;
RT "Insights from the complete genome sequence of Mycobacterium marinum on the
RT evolution of Mycobacterium tuberculosis.";
RL Genome Res. 18:729-741(2008).
RN [2]
RP FUNCTION.
RX PubMed=19602152; DOI=10.1111/j.1365-2958.2009.06783.x;
RA Abdallah A.M., Verboom T., Weerdenburg E.M., Gey van Pittius N.C.,
RA Mahasha P.W., Jimenez C., Parra M., Cadieux N., Brennan M.J.,
RA Appelmelk B.J., Bitter W.;
RT "PPE and PE_PGRS proteins of Mycobacterium marinum are transported via the
RT type VII secretion system ESX-5.";
RL Mol. Microbiol. 73:329-340(2009).
RN [3]
RP FUNCTION, SUBUNIT, AND SUBCELLULAR LOCATION.
RC STRAIN=ATCC BAA-535 / M;
RX PubMed=22925462; DOI=10.1111/j.1365-2958.2012.08206.x;
RA Houben E.N., Bestebroer J., Ummels R., Wilson L., Piersma S.R.,
RA Jimenez C.R., Ottenhoff T.H., Luirink J., Bitter W.;
RT "Composition of the type VII secretion system membrane complex.";
RL Mol. Microbiol. 86:472-484(2012).
CC -!- FUNCTION: An ATPase (By similarity). Part of the ESX-5 specialized
CC secretion system, which is responsible for the secretion of EsxN and a
CC number of PE_PGRS and PPE proteins. {ECO:0000250|UniProtKB:P9WNQ9,
CC ECO:0000269|PubMed:19602152, ECO:0000269|PubMed:22925462}.
CC -!- SUBUNIT: Part of the ESX-5 / type VII secretion system (T7SS), which is
CC composed of cytosolic and membrane components. The ESX-5 membrane
CC complex is composed of EccB5, EccC5, EccD5 and EccE5.
CC {ECO:0000269|PubMed:22925462}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000269|PubMed:22925462}; Single-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the EccB family. {ECO:0000305}.
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DR EMBL; CP000854; ACC41107.1; -; Genomic_DNA.
DR RefSeq; WP_012394381.1; NC_010612.1.
DR AlphaFoldDB; B2HST3; -.
DR SMR; B2HST3; -.
DR STRING; 216594.MMAR_2664; -.
DR EnsemblBacteria; ACC41107; ACC41107; MMAR_2664.
DR GeneID; 64261378; -.
DR KEGG; mmi:MMAR_2664; -.
DR eggNOG; COG3266; Bacteria.
DR HOGENOM; CLU_036302_3_0_11; -.
DR OMA; TESLWWL; -.
DR OrthoDB; 311112at2; -.
DR Proteomes; UP000001190; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR Gene3D; 2.40.50.910; -; 1.
DR Gene3D; 3.30.2390.20; -; 1.
DR InterPro; IPR007795; T7SS_EccB.
DR InterPro; IPR044857; T7SS_EccB_R1.
DR InterPro; IPR042485; T7SS_EccB_R3.
DR PANTHER; PTHR40765; PTHR40765; 1.
DR Pfam; PF05108; T7SS_ESX1_EccB; 1.
DR TIGRFAMs; TIGR03919; T7SS_EccB; 1.
PE 1: Evidence at protein level;
KW ATP-binding; Cell inner membrane; Cell membrane; Hydrolase; Membrane;
KW Nucleotide-binding; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..507
FT /note="ESX-5 secretion system ATPase EccB5"
FT /id="PRO_0000434749"
FT TRANSMEM 56..76
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 507 AA; 54103 MW; CA6B059894B0EE0E CRC64;
MAEQGRGQRG SGYGLGLSTR TQVTGYQFLA RRTAMALTRW RVRMEIEPGR RQTLAVVASV
SAALVICLGS LLWSFISPSG QINDSPIIAD RDSGALYVRV GDRLYPALNL ASARLITGRA
SNPHLVRGSQ IDSMPHGPLV GIPGAPSDFN PASPATSSWL VCDTVAGPST MPQSPHGVTV
TVIDGTPDLT GHRRVLKGSD AVVLRYGGDA WVIREGRRSR IDATDRSVLL PLGLTPEQVT
QARPMSHALY DALPVGPELV VPEVPDDGAA ATFPGAPGPV GTVIVTPQIS GPQQYSLVLT
DGVQTLPPLV AQILQNAGRP GNTKPVTVQP SSLAKMPVVN RLDLSAYPDD PLNVMDIRDN
PSTCWWWERT AGENRSRVQV ISGPNIPVAP HEMNKVVDLV KADMSGREAD QVYFGPNFAN
FVAVTGNNPA AQTTESLWWL TEAGARFGVE DTKEAREALG LGLTPSPAPW VVLRLLPQGP
TLSRADALVE HDTLPMDMSP AELVVPK