ID   ECCB5_MYCTO             Reviewed;         506 AA.
AC   P9WNQ8; L0TAD6; O53933; Q7D7Z1;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 38.
DE   RecName: Full=ESX-5 secretion system ATPase EccB5 {ECO:0000250|UniProtKB:P9WNQ9};
DE            EC=3.6.-.- {ECO:0000305};
DE   AltName: Full=ESX conserved component B5 {ECO:0000250|UniProtKB:P9WNQ9};
DE   AltName: Full=Type VII secretion system protein EccB5 {ECO:0000250|UniProtKB:P9WNQ9};
DE            Short=T7SS protein EccB5 {ECO:0000250|UniProtKB:P9WNQ9};
GN   Name=eccB5 {ECO:0000250|UniProtKB:P9WNQ9}; OrderedLocusNames=MT1832;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: An ATPase (By similarity). Part of the ESX-5 specialized
CC       secretion system, which is responsible for the secretion of EsxN and a
CC       number of PE_PGRS and PPE proteins, including PPE41.
CC       {ECO:0000250|UniProtKB:P9WNQ9}.
CC   -!- SUBUNIT: Part of the ESX-5 / type VII secretion system (T7SS), which is
CC       composed of cytosolic and membrane components. The ESX-5 membrane
CC       complex is composed of EccB5, EccC5, EccD5 and EccE5.
CC       {ECO:0000250|UniProtKB:B2HST3}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000250|UniProtKB:B2HST3}; Single-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the EccB family. {ECO:0000305}.
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DR   EMBL; AE000516; AAK46102.1; -; Genomic_DNA.
DR   PIR; H70928; H70928.
DR   RefSeq; WP_003899021.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WNQ8; -.
DR   SMR; P9WNQ8; -.
DR   EnsemblBacteria; AAK46102; AAK46102; MT1832.
DR   KEGG; mtc:MT1832; -.
DR   PATRIC; fig|83331.31.peg.1973; -.
DR   HOGENOM; CLU_036302_3_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.50.910; -; 1.
DR   Gene3D; 3.30.2390.20; -; 1.
DR   InterPro; IPR007795; T7SS_EccB.
DR   InterPro; IPR044857; T7SS_EccB_R1.
DR   InterPro; IPR042485; T7SS_EccB_R3.
DR   PANTHER; PTHR40765; PTHR40765; 1.
DR   Pfam; PF05108; T7SS_ESX1_EccB; 1.
DR   TIGRFAMs; TIGR03919; T7SS_EccB; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell inner membrane; Cell membrane; Hydrolase; Membrane;
KW   Nucleotide-binding; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..506
FT                   /note="ESX-5 secretion system ATPase EccB5"
FT                   /id="PRO_0000427084"
FT   TRANSMEM        56..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   506 AA;  53721 MW;  07116CB384B2814D CRC64;
     MAEESRGQRG SGYGLGLSTR TQVTGYQFLA RRTAMALTRW RVRMEIEPGR RQTLAVVASV
     SAALVICLGA LLWSFISPSG QLNESPIIAD RDSGALYVRV GDRLYPALNL ASARLITGRP
     DNPHLVRSSQ IATMPRGPLV GIPGAPSSFS PKSPPASSWL VCDTVATSSS IGSLQGVTVT
     VIDGTPDLTG HRQILSGSDA VVLRYGGDAW VIREGRRSRI EPTNRAVLLP LGLTPEQVSQ
     ARPMSRALFD ALPVGPELLV PEVPNAGGPA TFPGAPGPIG TVIVTPQISG PQQYSLVLGD
     GVQTLPPLVA QILQNAGSAG NTKPLTVEPS TLAKMPVVNR LDLSAYPDNP LEVVDIREHP
     STCWWWERTA GENRARVRVV SGPTIPVAAT EMNKVVSLVK ADTSGRQADQ VYFGPDHANF
     VAVTGNNPGA QTSESLWWVT DAGARFGVED SKEARDALGL TLTPSLAPWV ALRLLPQGPT
     LSRADALVEH DTLPMDMTPA ELVVPK