ECCC4_MYCTU
ID ECCC4_MYCTU Reviewed; 1236 AA.
AC P9WNA7; L0TCS5; O06264; Q8VJ07;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 03-AUG-2022, entry version 35.
DE RecName: Full=ESX-4 secretion system protein EccC4;
DE AltName: Full=ESX conserved component C4;
DE AltName: Full=Type VII secretion system protein EccC4;
DE Short=T7SS protein EccC4;
GN Name=eccC4; OrderedLocusNames=Rv3447c;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP GENE NAME.
RX PubMed=19876390; DOI=10.1371/journal.ppat.1000507;
RA Bitter W., Houben E.N., Bottai D., Brodin P., Brown E.J., Cox J.S.,
RA Derbyshire K., Fortune S.M., Gao L.Y., Liu J., Gey van Pittius N.C.,
RA Pym A.S., Rubin E.J., Sherman D.R., Cole S.T., Brosch R.;
RT "Systematic genetic nomenclature for type VII secretion systems.";
RL PLoS Pathog. 5:E1000507-E1000507(2009).
CC -!- SUBUNIT: Part of the ESX-4 / type VII secretion system (T7SS), which is
CC composed of cytosolic and membrane components. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AL123456; CCP46269.1; -; Genomic_DNA.
DR PIR; E70977; E70977.
DR RefSeq; NP_217964.1; NC_000962.3.
DR RefSeq; WP_003912232.1; NZ_NVQJ01000065.1.
DR AlphaFoldDB; P9WNA7; -.
DR SMR; P9WNA7; -.
DR STRING; 83332.Rv3447c; -.
DR PaxDb; P9WNA7; -.
DR GeneID; 887581; -.
DR KEGG; mtu:Rv3447c; -.
DR TubercuList; Rv3447c; -.
DR eggNOG; COG1674; Bacteria.
DR OMA; WEWMKWL; -.
DR PhylomeDB; P9WNA7; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR Gene3D; 3.40.50.300; -; 3.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR023836; EccCa-like_Actinobacteria.
DR InterPro; IPR023837; EccCb-like_Actinobacteria.
DR InterPro; IPR002543; FtsK_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF01580; FtsK_SpoIIIE; 3.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; SSF52540; 3.
DR TIGRFAMs; TIGR03924; T7SS_EccC_a; 1.
DR TIGRFAMs; TIGR03925; T7SS_EccC_b; 1.
DR PROSITE; PS50901; FTSK; 3.
PE 3: Inferred from homology;
KW ATP-binding; Cell membrane; Membrane; Nucleotide-binding;
KW Reference proteome; Repeat; Transmembrane; Transmembrane helix.
FT CHAIN 1..1236
FT /note="ESX-4 secretion system protein EccC4"
FT /id="PRO_0000393431"
FT TRANSMEM 32..52
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..79
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 407..607
FT /note="FtsK 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00289"
FT DOMAIN 747..936
FT /note="FtsK 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00289"
FT DOMAIN 1018..1201
FT /note="FtsK 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00289"
FT BINDING 430..437
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00289"
FT BINDING 765..772
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00289"
FT BINDING 1035..1042
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00289"
SQ SEQUENCE 1236 AA; 131896 MW; 5FE67CAF6786AE2E CRC64;
MNSGPACATA DILVAPPPEL RRSEPSSLLI RLLPVVMSVA TVGVMVTVFL PGSPATRHPT
FLAFPMMMLV SLVVTAVTGR GRRHVSGIHN DRVDYLGYLS VLRTSVTQTA AAQHVSLNWT
HPDPATLWTL IGGPRMWERR PGAADFCRIR VGVGSAPLAT RLVVGQLPPA QRADPVTRAA
LRCFLAAHAT IADAPIAIPL RVGGPIAIDG DPTKVRGLLR AMICQLAVWH SPEELLIAGV
VSDRNRAHWD WLKWLPHNQH PNACDALGPA PMVYSTLAEM QNALAATVLA HVVAIVDTAE
RGNGAITGVI TIEVGARRDG APPVVRCAGE VTALACPDQL EPQDALVCAR RLAAHRVGHS
GRTFIRGSGW AELVGIGDVA AFDPSTLWRN VNQHDRLRVP IGVTPDGTAV QLDIKEAAEQ
GMGPHGLCVG ATGSGKSELL RTIALGMMAR NSPEVLNLLL VDFKGGATFL DLAGAPHVAA
VITNLAEEAP LVARMQDALA GEMSRRQQLL RMAGHLVSVT AYQRARQTGA QLPCLPILFI
VVDEFSELLS QHPEFVDVFL AIGRVGRSLG MHLLLASQRL DEGRLRGLET HLSYRMCLKT
WSASESRNVL GTQDAYQLPN TPGAGLLQTG TGELIRFQTA FVSGPLRRAS PSAVHPVAPP
SVRPFTTHAA APVTAGPVGG TAEVPTPTVL HAVLDRLVGH GPAAHQVWLP PLDEPPMLGA
LLRDAEPAQA ELAVPIGIVD RPFEQSRVPL TIDLSGAAGN VAVVGAPQTG KSTALRTLIM
ALAATHDAGR VQFYCLDFGG GALAQVDELP HVGAVAGRAQ PQLASRMLAE LESAVRFREA
FFRDHGIDSV ARYRQLRAKS AAESFADIFL VIDGWASLRQ EFAALEESIV ALAAQGLSFG
VHVALSAARW AEIRPSLRDQ IGSRIELRLA DPADSELDRR QAQRVPVDRP GRGLSRDGMH
MVIALPDLDG VALRRRSGDP VAPPIPLLPA RVDYDSVVAR AGDELGAHIL LGLEERRGQP
VAVDFGRHPH LLVLGDNECG KTAALRTLCR EIVRTHTAAR AQLLIVDFRH TLLDVIESEH
MSGYVSSPAA LGAKLSSLVD LLQARMPAPD VSQAQLRARS WWSGPDIYVV VDDYDLVAVS
SGNPLMVLLE YLPHARDLGL HLVVARRSGG AARALFEPVL ASLRDLGCRA LLMSGRPDEG
ALFGSSRPMP LPPGRGILVT GAGDEQLVQV AWSPPP
