ECCC5_MYCTO
ID ECCC5_MYCTO Reviewed; 1391 AA.
AC P9WNA4; L0T992; O53934; O53935; Q8VJW6;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 03-AUG-2022, entry version 37.
DE RecName: Full=ESX-5 secretion system protein EccC5 {ECO:0000250|UniProtKB:P9WNA5};
DE AltName: Full=ESX conserved component C5 {ECO:0000250|UniProtKB:P9WNA5};
DE AltName: Full=Type VII secretion system protein EccC5 {ECO:0000250|UniProtKB:P9WNA5};
DE Short=T7SS protein EccC5 {ECO:0000250|UniProtKB:P9WNA5};
GN Name=eccC5 {ECO:0000250|UniProtKB:P9WNA5}; OrderedLocusNames=MT1833;
OS Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83331;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 1551 / Oshkosh;
RX PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT laboratory strains.";
RL J. Bacteriol. 184:5479-5490(2002).
CC -!- FUNCTION: Part of the ESX-5 specialized secretion system, which is
CC responsible for the secretion of EsxN and a number of PE_PGRS and PPE
CC proteins, including PPE41. {ECO:0000250|UniProtKB:P9WNA5}.
CC -!- SUBUNIT: Part of the ESX-5 / type VII secretion system (T7SS), which is
CC composed of cytosolic and membrane components. The ESX-5 membrane
CC complex is composed of EccB5, EccC5, EccD5 and EccE5.
CC {ECO:0000250|UniProtKB:B2HST4}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000250|UniProtKB:B2HST4}; Multi-pass membrane protein
CC {ECO:0000255}.
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DR EMBL; AE000516; AAK46103.1; -; Genomic_DNA.
DR PIR; A70929; A70929.
DR PIR; B70929; B70929.
DR RefSeq; WP_003408799.1; NZ_KK341227.1.
DR AlphaFoldDB; P9WNA4; -.
DR SMR; P9WNA4; -.
DR EnsemblBacteria; AAK46103; AAK46103; MT1833.
DR KEGG; mtc:MT1833; -.
DR PATRIC; fig|83331.31.peg.1974; -.
DR HOGENOM; CLU_003134_1_0_11; -.
DR Proteomes; UP000001020; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR Gene3D; 3.40.50.300; -; 4.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR023836; EccCa-like_Actinobacteria.
DR InterPro; IPR023837; EccCb-like_Actinobacteria.
DR InterPro; IPR002543; FtsK_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF01580; FtsK_SpoIIIE; 2.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; SSF52540; 2.
DR TIGRFAMs; TIGR03924; T7SS_EccC_a; 1.
DR TIGRFAMs; TIGR03925; T7SS_EccC_b; 1.
DR PROSITE; PS50901; FTSK; 3.
PE 3: Inferred from homology;
KW ATP-binding; Cell inner membrane; Cell membrane; Membrane;
KW Nucleotide-binding; Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1391
FT /note="ESX-5 secretion system protein EccC5"
FT /id="PRO_0000427161"
FT TRANSMEM 38..58
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 476..678
FT /note="FtsK 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00289"
FT DOMAIN 858..1052
FT /note="FtsK 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00289"
FT DOMAIN 1161..1354
FT /note="FtsK 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00289"
FT BINDING 499..506
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00289"
FT BINDING 876..883
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00289"
FT BINDING 1178..1185
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00289"
SQ SEQUENCE 1391 AA; 152740 MW; DC7B8D899AD21820 CRC64;
MKRGFARPTP EKPPVIKPEN IVLSTPLSIP PPEGKPWWLI VVGVVVVGLL GGMVAMVFAS
GSHVFGGIGS IFPLFMMVGI MMMMFRGMGG GQQQMSRPKL DAMRAQFMLM LDMLRETAQE
SADSMDANYR WFHPAPNTLA AAVGSPRMWE RKPDGKDLNF GVVRVGVGMT RPEVTWGEPQ
NMPTDIELEP VTGKALQEFG RYQSVVYNLP KMVSLLVEPW YALVGEREQV LGLMRAIICQ
LAFSHGPDHV QMIVVSSDLD QWDWVKWLPH FGDSRRHDAA GNARMVYTSV REFAAEQAEL
FAGRGSFTPR HASSSAQTPT PHTVIIADVD DPQWEYVISA EGVDGVTFFD LTGSSMWTDI
PERKLQFDKT GVIEALPRDR DTWMVIDDKA WFFALTDQVS IAEAEEFAQK LAQWRLAEAY
EEIGQRVAHI GARDILSYYG IDDPGNIDFD SLWASRTDTM GRSRLRAPFG NRSDNGELLF
LDMKSLDEGG DGPHGVMSGT TGSGKSTLVR TVIESLMLSH PPEELQFVLA DLKGGSAVKP
FAGVPHVSRI ITDLEEDQAL MERFLDALWG EIARRKAICD SAGVDDAKEY NSVRARMRAR
GQDMAPLPML VVVIDEFYEW FRIMPTAVDV LDSIGRQGRA YWIHLMMASQ TIESRAEKLM
ENMGYRLVLK ARTAGAAQAA GVPNAVNLPA QAGLGYFRKS LEDIIRFQAE FLWRDYFQPG
VSIDGEEAPA LVHSIDYIRP QLFTNSFTPL EVSVGGPDIE PVVAQPNGEV LESDDIEGGE
DEDEEGVRTP KVGTVIIDQL RKIKFEPYRL WQPPLTQPVA IDDLVNRFLG RPWHKEYGSA
CNLVFPIGII DRPYKHDQPP WTVDTSGPGA NVLILGAGGS GKTTALQTLI CSAALTHTPQ
QVQFYCLAYS STALTTVSRI PHVGEVAGPT DPYGVRRTVA ELLALVRERK RSFLECGIAS
MEMFRRRKFG GEAGPVPDDG FGDVYLVIDN YRALAEENEV LIEQVNVIIN QGPSFGVHVV
VTADRESELR PPVRSGFGSR IELRLAAVED AKLVRSRFAK DVPVKPGRGM VAVNYVRLDS
DPQAGLHTLV ARPALGSTPD NVFECDSVVA AVSRLTSAQA PPVRRLPARF GVEQVRELAS
RDTRQGVGAG GIAWAISELD LAPVYLNFAE NSHLMVTGRR ECGRTTTLAT IMSEIGRLYA
PGASSAPPPA PGRPSAQVWL VDPRRQLLTA LGSDYVERFA YNLDGVVAMM GELAAALAGR
EPPPGLSAEE LLSRSWWSGP EIFLIVDDIQ QLPPGFDSPL HKAVPFVNRA ADVGLHVIVT
RTFGGWSSAG SDPMLRALHQ ANAPLLVMDA DPDEGFIRGK MKGGPLPRGR GLLMAEDTGV
FVQVAATEVR R
