ID   ECCD1_MYCTO             Reviewed;         511 AA.
AC   P9WNQ6; L0TGV6; O69741; Q7D4P2;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=ESX-1 secretion system protein EccD1 {ECO:0000250|UniProtKB:P9WNQ7};
DE   AltName: Full=ESX conserved component D1 {ECO:0000250|UniProtKB:P9WNQ7};
DE   AltName: Full=Type VII secretion system protein EccD1 {ECO:0000250|UniProtKB:P9WNQ7};
DE            Short=T7SS protein EccD1 {ECO:0000250|UniProtKB:P9WNQ7};
GN   Name=eccD1 {ECO:0000250|UniProtKB:P9WNQ7}; Synonyms=snm4;
GN   OrderedLocusNames=MT3991;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Part of the ESX-1 specialized secretion system, which
CC       delivers several virulence factors to host cells during infection,
CC       including the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10).
CC       {ECO:0000250|UniProtKB:P9WNQ7}.
CC   -!- SUBUNIT: Part of the ESX-1 / type VII secretion system (T7SS), which is
CC       composed of cytosolic and membrane components. The ESX-1 membrane
CC       complex is composed of EccB1, EccCa1, EccCb1, EccD1 and EccE1.
CC       {ECO:0000250|UniProtKB:P9WNQ7}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000250|UniProtKB:P9WNQ7}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the EccD/Snm4 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK48359.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AE000516; AAK48359.1; ALT_INIT; Genomic_DNA.
DR   PIR; C70803; C70803.
DR   RefSeq; WP_003399976.1; NZ_KK341228.1.
DR   AlphaFoldDB; P9WNQ6; -.
DR   SMR; P9WNQ6; -.
DR   EnsemblBacteria; AAK48359; AAK48359; MT3991.
DR   KEGG; mtc:MT3991; -.
DR   PATRIC; fig|83331.31.peg.4294; -.
DR   HOGENOM; CLU_038936_0_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR006707; T7SS_EccD.
DR   InterPro; IPR024962; YukD-like.
DR   Pfam; PF08817; YukD; 1.
DR   PIRSF; PIRSF017804; Secretion_EccD1; 1.
DR   TIGRFAMs; TIGR03920; T7SS_EccD; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..511
FT                   /note="ESX-1 secretion system protein EccD1"
FT                   /id="PRO_0000427085"
FT   TRANSMEM        144..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        171..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        203..223
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        228..248
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        258..278
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        286..306
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        368..388
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        389..409
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        421..441
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        445..465
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        483..503
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   511 AA;  53999 MW;  32B7C158E6E7C6FF CRC64;
     MSAPAVAAGP TAAGATAARP ATTRVTILTG RRMTDLVLPA AVPMETYIDD TVAVLSEVLE
     DTPADVLGGF DFTAQGVWAF ARPGSPPLKL DQSLDDAGVV DGSLLTLVSV SRTERYRPLV
     EDVIDAIAVL DESPEFDRTA LNRFVGAAIP LLTAPVIGMA MRAWWETGRS LWWPLAIGIL
     GIAVLVGSFV ANRFYQSGHL AECLLVTTYL LIATAAALAV PLPRGVNSLG APQVAGAATA
     VLFLTLMTRG GPRKRHELAS FAVITAIAVI AAAAAFGYGY QDWVPAGGIA FGLFIVTNAA
     KLTVAVARIA LPPIPVPGET VDNEELLDPV ATPEATSEET PTWQAIIASV PASAVRLTER
     SKLAKQLLIG YVTSGTLILA AGAIAVVVRG HFFVHSLVVA GLITTVCGFR SRLYAERWCA
     WALLAATVAI PTGLTAKLII WYPHYAWLLL SVYLTVALVA LVVVGSMAHV RRVSPVVKRT
     LELIDGAMIA AIIPMLLWIT GVYDTVRNIR F