ID   ECCD2_MYCTO             Reviewed;         509 AA.
AC   P9WNQ4; L0TGW9; O05457; Q8VIR4;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 24.
DE   RecName: Full=ESX-2 secretion system protein eccD2;
DE   AltName: Full=ESX conserved component D2;
DE   AltName: Full=Type VII secretion system protein eccD2;
DE            Short=T7SS protein eccD2;
GN   Name=eccD2; OrderedLocusNames=MT4002;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- SUBUNIT: Part of the ESX-2 / type VII secretion system (T7SS), which is
CC       composed of cytosolic and membrane components. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the EccD/Snm4 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK48369.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AE000516; AAK48369.1; ALT_INIT; Genomic_DNA.
DR   PIR; H70597; H70597.
DR   RefSeq; WP_003917858.1; NZ_KK341228.1.
DR   AlphaFoldDB; P9WNQ4; -.
DR   SMR; P9WNQ4; -.
DR   EnsemblBacteria; AAK48369; AAK48369; MT4002.
DR   KEGG; mtc:MT4002; -.
DR   PATRIC; fig|83331.31.peg.4309; -.
DR   HOGENOM; CLU_042648_0_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR044049; EccD_transm.
DR   InterPro; IPR006707; T7SS_EccD.
DR   InterPro; IPR024962; YukD-like.
DR   Pfam; PF19053; EccD; 1.
DR   Pfam; PF08817; YukD; 1.
DR   TIGRFAMs; TIGR03920; T7SS_EccD; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..509
FT                   /note="ESX-2 secretion system protein eccD2"
FT                   /id="PRO_0000427086"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        170..190
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        196..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        222..242
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        248..268
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        281..301
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        364..384
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        389..409
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        418..438
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        449..469
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        487..507
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   509 AA;  53277 MW;  3902A4D397E2F24C CRC64;
     MTAPHKVAFP ARCAVNICYD KHLCSQVFPA GIPVEGFFEG MVELFDADLK RKGFDGVALP
     AGSYELHKIN GVRLDINKSL DELGVQDGNT LVLVPRVAGE SFEPQYESLS TGLAAMGKWL
     GRDGGDRMFA PVTSLTAAHT AMAIIAMAVG VVLALTLRTR TITDSPVPAA MAGGIGVLLV
     IGALVVWWGW RERRDLFSGF GWLAVVLLAV AAACAPPGAL GAAHALIGLV VVVLGAITIG
     VATRKRWQTA VVTAVVTVCG ILAAVAAVRM FRPVSMQVLA ICVLVGLLVL IRMTPTVALW
     VARVRPPHFG SITGRDLFAR RAGMPVDTVA PVSEADADDE DNELTDITAR GTAIAASARL
     VNAVQVGMCV GVSLVLPAAV WGVLTPRQPW AWLALLVAGL TVGLFITQGR GFAAKYQAVA
     LVCGASAAVC AGVLKYALDT PKGVQTGLLW PAIFVAAFAA LGLAVALVVP ATRFRPIIRL
     TVEWLEVLAM IALLPAAAAL GGLFAWLRH