ECCD2_MYCTU
ID ECCD2_MYCTU Reviewed; 509 AA.
AC P9WNQ5; L0TGW9; O05457; Q8VIR4;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 25-MAY-2022, entry version 32.
DE RecName: Full=ESX-2 secretion system protein eccD2;
DE AltName: Full=ESX conserved component D2;
DE AltName: Full=Type VII secretion system protein eccD2;
DE Short=T7SS protein eccD2;
GN Name=eccD2; OrderedLocusNames=Rv3887c;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].
RX PubMed=19099550; DOI=10.1186/1752-0509-2-109;
RA Raman K., Yeturu K., Chandra N.;
RT "targetTB: a target identification pipeline for Mycobacterium tuberculosis
RT through an interactome, reactome and genome-scale structural analysis.";
RL BMC Syst. Biol. 2:109-109(2008).
RN [3]
RP GENE NAME.
RX PubMed=19876390; DOI=10.1371/journal.ppat.1000507;
RA Bitter W., Houben E.N., Bottai D., Brodin P., Brown E.J., Cox J.S.,
RA Derbyshire K., Fortune S.M., Gao L.Y., Liu J., Gey van Pittius N.C.,
RA Pym A.S., Rubin E.J., Sherman D.R., Cole S.T., Brosch R.;
RT "Systematic genetic nomenclature for type VII secretion systems.";
RL PLoS Pathog. 5:E1000507-E1000507(2009).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT mass spectrometry.";
RL Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC -!- SUBUNIT: Part of the ESX-2 / type VII secretion system (T7SS), which is
CC composed of cytosolic and membrane components. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- MISCELLANEOUS: Was identified as a high-confidence drug target.
CC -!- SIMILARITY: Belongs to the EccD/Snm4 family. {ECO:0000305}.
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DR EMBL; AL123456; CCP46716.1; -; Genomic_DNA.
DR PIR; H70597; H70597.
DR RefSeq; NP_218404.1; NC_000962.3.
DR RefSeq; WP_003900775.1; NZ_NVQJ01000005.1.
DR AlphaFoldDB; P9WNQ5; -.
DR SMR; P9WNQ5; -.
DR STRING; 83332.Rv3887c; -.
DR PaxDb; P9WNQ5; -.
DR DNASU; 886211; -.
DR GeneID; 886211; -.
DR KEGG; mtu:Rv3887c; -.
DR TubercuList; Rv3887c; -.
DR eggNOG; ENOG5031ZT9; Bacteria.
DR OMA; PTIALWV; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042783; P:evasion of host immune response; IMP:MTBBASE.
DR InterPro; IPR044049; EccD_transm.
DR InterPro; IPR006707; T7SS_EccD.
DR InterPro; IPR024962; YukD-like.
DR Pfam; PF19053; EccD; 1.
DR Pfam; PF08817; YukD; 1.
DR TIGRFAMs; TIGR03920; T7SS_EccD; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..509
FT /note="ESX-2 secretion system protein eccD2"
FT /id="PRO_0000393234"
FT TRANSMEM 135..155
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 170..190
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..216
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 222..242
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 248..268
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 281..301
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 364..384
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 389..409
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 418..438
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 449..469
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 487..507
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 509 AA; 53278 MW; 00F961EAF1C4B1B9 CRC64;
MTAPHKVAFP ARCAVNICYD KHLCSQVFPA GIPVEGFFEG MVELFDADLK RKGFDGVALP
AGSYELHKIN GVRLDINKSL DELGVQDGDT LVLVPRVAGE SFEPQYESLS TGLAAMGKWL
GRDGGDRMFA PVTSLTAAHT AMAIIAMAVG VVLALTLRTR TITDSPVPAA MAGGIGVLLV
IGALVVWWGW RERRDLFSGF GWLAVVLLAV AAACAPPGAL GAAHALIGLV VVVLGAITIG
VATRKRWQTA VVTAVVTVCG ILAAVAAVRM FRPVSMQVLA ICVLVGLLVL IRMTPTVALW
VARVRPPHFG SITGRDLFAR RAGMPVDTVA PVSEADADDE DNELTDITAR GTAIAASARL
VNAVQVGMCV GVSLVLPAAV WGVLTPRQPW AWLALLVAGL TVGLFITQGR GFAAKYQAVA
LVCGASAAVC AGVLKYALDT PKGVQTGLLW PAIFVAAFAA LGLAVALVVP ATRFRPIIRL
TVEWLEVLAM IALLPAAAAL GGLFAWLRH
