ID   ECCD3_MYCTO             Reviewed;         472 AA.
AC   P9WNQ2; L0T326; O86362; Q7DA32;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=ESX-3 secretion system protein EccD3 {ECO:0000250|UniProtKB:P9WNQ3};
DE   AltName: Full=ESX conserved component D3 {ECO:0000250|UniProtKB:P9WNQ3};
DE   AltName: Full=Type VII secretion system protein EccD3 {ECO:0000250|UniProtKB:P9WNQ3};
DE            Short=T7SS protein EccD3 {ECO:0000250|UniProtKB:P9WNQ3};
GN   Name=eccD3 {ECO:0000250|UniProtKB:P9WNQ3}; OrderedLocusNames=MT0303;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Part of the ESX-3 specialized secretion system, which is
CC       important for iron and zinc uptake or homeostasis.
CC       {ECO:0000250|UniProtKB:P9WNQ3}.
CC   -!- SUBUNIT: Part of the ESX-3 / type VII secretion system (T7SS), which is
CC       composed of cytosolic and membrane components. The ESX-3 membrane
CC       complex is composed of EccB3, EccC3, EccD3 and EccE3.
CC       {ECO:0000250|UniProtKB:B2HSU6}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000250|UniProtKB:B2HSU6}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the EccD/Snm4 family. {ECO:0000305}.
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DR   EMBL; AE000516; AAK44527.1; -; Genomic_DNA.
DR   PIR; H70836; H70836.
DR   RefSeq; WP_003401524.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WNQ2; -.
DR   SMR; P9WNQ2; -.
DR   EnsemblBacteria; AAK44527; AAK44527; MT0303.
DR   KEGG; mtc:MT0303; -.
DR   PATRIC; fig|83331.31.peg.326; -.
DR   HOGENOM; CLU_578499_0_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR006707; T7SS_EccD.
DR   InterPro; IPR024962; YukD-like.
DR   Pfam; PF08817; YukD; 1.
DR   PIRSF; PIRSF017804; Secretion_EccD1; 1.
DR   TIGRFAMs; TIGR03920; T7SS_EccD; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..472
FT                   /note="ESX-3 secretion system protein EccD3"
FT                   /id="PRO_0000427087"
FT   TRANSMEM        121..141
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        155..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        183..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        211..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        236..256
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        258..278
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        327..347
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        349..369
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        381..401
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        405..425
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        450..470
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   472 AA;  47944 MW;  2A132D3AB0A7F3D1 CRC64;
     MSGTVMQIVR VAILADSRLT EMALPAELPL REILPAVQRL VVPSAQNGDG GQADSGAAVQ
     LSLAPVGGQP FSLDASLDTV GVVDGDLLVL QPVPAGPAAP GIVEDIADAA MIFSTSRLKP
     WGIAHIQRGA LAAVIAVALL ATGLTVTYRV ATGVLAGLLA VAGIAVASAL AGLLITIRSP
     RSGIALSIAA LVPIGAALAL AVPGKFGPAQ VLLGAAGVAA WSLIALMIPS AERERVVAFF
     TAAAVVGASV ALAAGAQLLW QLPLLSIGCG LIVAALLVTI QAAQLSALWA RFPLPVIPAP
     GDPTPSAPPL RLLEDLPRRV RVSDAHQSGF IAAAVLLSVL GSVAIAVRPE ALSVVGWYLV
     AATAAAATLR ARVWDSAACK AWLLAQPYLV AGVLLVFYTA TGRYVAAFGA VLVLAVLMLA
     WVVVALNPGI ASPESYSLPL RRLLGLVAAG LDVSLIPVMA YLVGLFAWVL NR