ECCD4_MYCTO
ID ECCD4_MYCTO Reviewed; 467 AA.
AC P9WNQ0; L0TFN3; O33354; Q7D5I9;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 25-MAY-2022, entry version 32.
DE RecName: Full=ESX-4 secretion system protein eccD4;
DE AltName: Full=ESX conserved component D4;
DE AltName: Full=Type VII secretion system protein eccD4;
DE Short=T7SS protein eccD4;
GN Name=eccD4; OrderedLocusNames=MT3554;
OS Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83331;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 1551 / Oshkosh;
RX PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT laboratory strains.";
RL J. Bacteriol. 184:5479-5490(2002).
CC -!- SUBUNIT: Part of the ESX-4 / type VII secretion system (T7SS), which is
CC composed of cytosolic and membrane components. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the EccD/Snm4 family. {ECO:0000305}.
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DR EMBL; AE000516; AAK47894.1; -; Genomic_DNA.
DR PIR; E70564; E70564.
DR RefSeq; WP_003900062.1; NZ_KK341227.1.
DR AlphaFoldDB; P9WNQ0; -.
DR SMR; P9WNQ0; -.
DR EnsemblBacteria; AAK47894; AAK47894; MT3554.
DR KEGG; mtc:MT3554; -.
DR PATRIC; fig|83331.31.peg.3813; -.
DR HOGENOM; CLU_028325_2_0_11; -.
DR Proteomes; UP000001020; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR044049; EccD_transm.
DR InterPro; IPR006707; T7SS_EccD.
DR InterPro; IPR024962; YukD-like.
DR Pfam; PF19053; EccD; 1.
DR Pfam; PF08817; YukD; 1.
DR PIRSF; PIRSF017804; Secretion_EccD1; 1.
DR TIGRFAMs; TIGR03920; T7SS_EccD; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT CHAIN 1..467
FT /note="ESX-4 secretion system protein eccD4"
FT /id="PRO_0000427088"
FT TRANSMEM 122..142
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 152..172
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 186..206
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 209..229
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 264..284
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 319..339
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 344..364
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 374..394
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 401..421
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 439..459
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 467 AA; 46731 MW; 91FF9CD1FD51F2F4 CRC64;
MPTSDPGLRR VTVHAGAQAV DLTLPAAVPV ATLIPSIVDI LGDRGASPAT AARYQLSALG
APALPNATTL AQCGIRDGAV LVLHKSSAQP PTPRCDDVAE AVAAALDTTA RPQCQRTTRL
SGALAASCIT AGGGLMLVRN ALGTNVTRYS DATAGVVAAA GLAALLFAVI ACRTYRDPIA
GLTLSVIATI FGAVAGLLAV PGVPGVHSVL VAAMAAAATS VLAMRITGCG GITLTAVACC
AVVVAAATLV GAITAAPVPA IGSLATLASF GLLEVSARMA VLLAGLSPRL PPALNPDDAD
ALPTTDRLTT RANRADAWLT SLLAAFAASA TIGAIGTAVA THGIHRSSMG GIALAAVTGA
LLLLRARSAD TRRSLVFAIC GITTVATAFT VAADRALEHG PWIAALTAML AAVAMFLGFV
APALSLSPVT YRTIELLECL ALIAMVPLTA WLCGAYSAVR HLDLTWT
