ECCD5_MYCMM
ID ECCD5_MYCMM Reviewed; 503 AA.
AC B2HSU6;
DT 11-NOV-2015, integrated into UniProtKB/Swiss-Prot.
DT 10-JUN-2008, sequence version 1.
DT 25-MAY-2022, entry version 54.
DE RecName: Full=ESX-5 secretion system protein EccD5 {ECO:0000305};
DE AltName: Full=ESX conserved component D5 {ECO:0000305};
DE AltName: Full=Type VII secretion system protein EccD5 {ECO:0000305};
DE Short=T7SS protein EccD5 {ECO:0000305};
GN Name=eccD5 {ECO:0000303|PubMed:22925462};
GN OrderedLocusNames=MMAR_2677 {ECO:0000312|EMBL:ACC41120.1};
OS Mycobacterium marinum (strain ATCC BAA-535 / M).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=216594;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-535 / M;
RX PubMed=18403782; DOI=10.1101/gr.075069.107;
RA Stinear T.P., Seemann T., Harrison P.F., Jenkin G.A., Davies J.K.,
RA Johnson P.D., Abdellah Z., Arrowsmith C., Chillingworth T., Churcher C.,
RA Clarke K., Cronin A., Davis P., Goodhead I., Holroyd N., Jagels K.,
RA Lord A., Moule S., Mungall K., Norbertczak H., Quail M.A.,
RA Rabbinowitsch E., Walker D., White B., Whitehead S., Small P.L., Brosch R.,
RA Ramakrishnan L., Fischbach M.A., Parkhill J., Cole S.T.;
RT "Insights from the complete genome sequence of Mycobacterium marinum on the
RT evolution of Mycobacterium tuberculosis.";
RL Genome Res. 18:729-741(2008).
RN [2]
RP FUNCTION.
RX PubMed=19602152; DOI=10.1111/j.1365-2958.2009.06783.x;
RA Abdallah A.M., Verboom T., Weerdenburg E.M., Gey van Pittius N.C.,
RA Mahasha P.W., Jimenez C., Parra M., Cadieux N., Brennan M.J.,
RA Appelmelk B.J., Bitter W.;
RT "PPE and PE_PGRS proteins of Mycobacterium marinum are transported via the
RT type VII secretion system ESX-5.";
RL Mol. Microbiol. 73:329-340(2009).
RN [3]
RP FUNCTION, SUBUNIT, AND SUBCELLULAR LOCATION.
RC STRAIN=ATCC BAA-535 / M;
RX PubMed=22925462; DOI=10.1111/j.1365-2958.2012.08206.x;
RA Houben E.N., Bestebroer J., Ummels R., Wilson L., Piersma S.R.,
RA Jimenez C.R., Ottenhoff T.H., Luirink J., Bitter W.;
RT "Composition of the type VII secretion system membrane complex.";
RL Mol. Microbiol. 86:472-484(2012).
CC -!- FUNCTION: Part of the ESX-5 specialized secretion system, which is
CC responsible for the secretion of EsxN and a number of PE_PGRS and PPE
CC proteins (PubMed:19602152, PubMed:22925462). This component is
CC essential for ESX-5 complex stability and secretion (PubMed:22925462).
CC {ECO:0000269|PubMed:19602152, ECO:0000269|PubMed:22925462}.
CC -!- SUBUNIT: Part of the ESX-5 / type VII secretion system (T7SS), which is
CC composed of cytosolic and membrane components. The ESX-5 membrane
CC complex is composed of EccB5, EccC5, EccD5 and EccE5.
CC {ECO:0000269|PubMed:22925462}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000269|PubMed:22925462}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the EccD/Snm4 family. {ECO:0000305}.
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DR EMBL; CP000854; ACC41120.1; -; Genomic_DNA.
DR RefSeq; WP_012394391.1; NC_010612.1.
DR AlphaFoldDB; B2HSU6; -.
DR SMR; B2HSU6; -.
DR STRING; 216594.MMAR_2677; -.
DR EnsemblBacteria; ACC41120; ACC41120; MMAR_2677.
DR GeneID; 64261390; -.
DR KEGG; mmi:MMAR_2677; -.
DR eggNOG; ENOG502ZAY5; Bacteria.
DR HOGENOM; CLU_041782_0_0_11; -.
DR OMA; WIRFIPD; -.
DR OrthoDB; 1786282at2; -.
DR Proteomes; UP000001190; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR044049; EccD_transm.
DR InterPro; IPR006707; T7SS_EccD.
DR InterPro; IPR024962; YukD-like.
DR Pfam; PF19053; EccD; 1.
DR Pfam; PF08817; YukD; 1.
DR PIRSF; PIRSF017804; Secretion_EccD1; 1.
DR TIGRFAMs; TIGR03920; T7SS_EccD; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..503
FT /note="ESX-5 secretion system protein EccD5"
FT /id="PRO_0000434751"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..220
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 224..244
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 250..270
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 359..379
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 414..434
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 443..463
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 480..500
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 503 AA; 53516 MW; 49D51B86C72DC2FA CRC64;
MTAVADAPQA ELEGVSSPRA VVVGIMAGEG VQIGVLLDAN APVSVMTDPL LKVVNSRLRE
LGESTLEAAG RGRWALCLID GSPLRATQSL TEQDVYDGDR LWIRFIPDTE HRSQVIEHIS
TAVASNLSKR FASIDPVVAV QVGAGMVGTG VILASGVLGW WRWHHNTWLT TIFASVIAVL
VLMVAMMLLM RATTDADRRV ADIMLVSGLA PLTVAAASAP PGSVGSPQAV LGFGVLSIAA
ALALRFTGRR LAIYTAIVTI CGLTTLASLS RMVAATSAVT LFATMLLICV VMYHASPALS
RRLSGIRLPV FPSATSRWVF EARPDLPTTV AVAAGGPPVL EGPASVRDVV LQAERARSFL
SGLLVGLGVL MVVSLTSLCN PHTSERWLPL MLAGFTSGFL MLRGRSYVDR WQSITLAVTA
VIVVAAVSVR YALVLSSPLS VSIVASLLVL LPAAGMTAAA VVPNTIYSPL FRKFVEWTEY
LCLMPIFPLA FWLMNVYAAI RYR
