ID   ECCD5_MYCTO             Reviewed;         503 AA.
AC   P9WNP8; L0T9A2; O53944; Q7D7Y4;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=ESX-5 secretion system protein EccD5 {ECO:0000250|UniProtKB:P9WNP9};
DE   AltName: Full=ESX conserved component D5 {ECO:0000250|UniProtKB:P9WNP9};
DE   AltName: Full=Type VII secretion system protein EccD5 {ECO:0000250|UniProtKB:P9WNP9};
DE            Short=T7SS protein EccD5 {ECO:0000250|UniProtKB:P9WNP9};
GN   Name=eccD5 {ECO:0000250|UniProtKB:P9WNP9}; OrderedLocusNames=MT1844;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Part of the ESX-5 specialized secretion system, which is
CC       responsible for the secretion of EsxN and a number of PE_PGRS and PPE
CC       proteins, including PPE41. {ECO:0000250|UniProtKB:P9WNP9}.
CC   -!- SUBUNIT: Part of the ESX-5 / type VII secretion system (T7SS), which is
CC       composed of cytosolic and membrane components. The ESX-5 membrane
CC       complex is composed of EccB5, EccC5, EccD5 and EccE5.
CC       {ECO:0000250|UniProtKB:B2HSU6}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000250|UniProtKB:B2HSU6}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the EccD/Snm4 family. {ECO:0000305}.
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DR   EMBL; AE000516; AAK46115.1; -; Genomic_DNA.
DR   PIR; D70930; D70930.
DR   RefSeq; WP_003900411.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WNP8; -.
DR   SMR; P9WNP8; -.
DR   EnsemblBacteria; AAK46115; AAK46115; MT1844.
DR   GeneID; 45425772; -.
DR   KEGG; mtc:MT1844; -.
DR   PATRIC; fig|83331.31.peg.1986; -.
DR   HOGENOM; CLU_041782_0_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR044049; EccD_transm.
DR   InterPro; IPR006707; T7SS_EccD.
DR   InterPro; IPR024962; YukD-like.
DR   Pfam; PF19053; EccD; 1.
DR   Pfam; PF08817; YukD; 1.
DR   PIRSF; PIRSF017804; Secretion_EccD1; 1.
DR   TIGRFAMs; TIGR03920; T7SS_EccD; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..503
FT                   /note="ESX-5 secretion system protein EccD5"
FT                   /id="PRO_0000427089"
FT   TRANSMEM        137..157
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        169..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        200..220
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        224..244
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        250..270
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..292
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        359..379
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        382..402
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        413..433
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        439..459
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        480..500
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   503 AA;  53435 MW;  80C27906BA60DEF3 CRC64;
     MTAVADAPQA DIEGVASPQA VVVGVMAGEG VQIGVLLDAN APVSVMTDPL LKVVNSRLRE
     LGEAPLEATG RGRWALCLVD GAPLRATQSL TEQDVYDGDR LWIRFIADTE RRSQVIEHIS
     TAVASDLSKR FARIDPIVAV QVGASMVATG VVLATGVLGW WRWHHNTWLT TIYTAVIGVL
     VLAVAMLLLM RAKTDADRRV ADIMLMSAIM PVTVAAAAAP PGPVGSPQAV LGFGVLTVAA
     ALALRFTGRR LGIYTTIVII GALTMLAALA RMVAATSAVT LLSSLLLICV VAYHAAPALS
     RRLAGIRLPV FPSATSRWVF EARPDLPTTV VVSGGSAPVL EGPSSVRDVL LQAERARSFL
     SGLLTGLGVM VVVCMTSLCD PHTGQRWLPL ILAGFTSGFL LLRGRSYVDR WQSITLAGTA
     VIIAAAVCVR YALELSSPLA VSIVAAILVL LPAAGMAAAA HVPHTIYSPL FRKFVEWIEY
     LCLMPIFPLA LWLMNVYAAI RYR