ID   ECCE1_MYCTO             Reviewed;         462 AA.
AC   P9WJE8; L0TGW4; O05462; Q7D4N9;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 36.
DE   RecName: Full=ESX-1 secretion system protein EccE1 {ECO:0000250|UniProtKB:P9WJE9};
DE   AltName: Full=ESX conserved component E1 {ECO:0000250|UniProtKB:P9WJE9};
DE   AltName: Full=Type VII secretion system protein EccE1 {ECO:0000250|UniProtKB:P9WJE9};
DE            Short=T7SS protein EccE1 {ECO:0000250|UniProtKB:P9WJE9};
GN   Name=eccE1 {ECO:0000250|UniProtKB:P9WJE9}; Synonyms=snm7;
GN   OrderedLocusNames=MT3997;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Part of the ESX-1 specialized secretion system, which
CC       delivers several virulence factors to host cells during infection,
CC       including the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10).
CC       {ECO:0000250|UniProtKB:P9WJE9}.
CC   -!- SUBUNIT: Part of the ESX-1 / type VII secretion system (T7SS), which is
CC       composed of cytosolic and membrane components. The ESX-1 membrane
CC       complex is composed of EccB1, EccCa1, EccCb1, EccD1 and EccE1.
CC       {ECO:0000250|UniProtKB:P9WJE9}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000250|UniProtKB:P9WJE9}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the EccE family. {ECO:0000305}.
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DR   EMBL; AE000516; AAK48365.1; -; Genomic_DNA.
DR   PIR; C70597; C70597.
DR   RefSeq; WP_003400000.1; NZ_KK341228.1.
DR   AlphaFoldDB; P9WJE8; -.
DR   EnsemblBacteria; AAK48365; AAK48365; MT3997.
DR   GeneID; 45427885; -.
DR   KEGG; mtc:MT3997; -.
DR   PATRIC; fig|83331.31.peg.4301; -.
DR   HOGENOM; CLU_587698_0_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR021368; T7SS_EccE.
DR   Pfam; PF11203; EccE; 1.
DR   TIGRFAMs; TIGR03923; T7SS_EccE; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..462
FT                   /note="ESX-1 secretion system protein EccE1"
FT                   /id="PRO_0000427842"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   462 AA;  50397 MW;  BB199AB9F8969E5F CRC64;
     MRNPLGLRFS TGHALLASAL APPCIIAFLE TRYWWAGIAL ASLGVIVATV TFYGRRITGW
     VAAVYAWLRR RRRPPDSSSE PVVGATVKPG DHVAVRWQGE FLVAVIELIP RPFTPTVIVD
     GQAHTDDMLD TGLVEELLSV HCPDLEADIV SAGYRVGNTA APDVVSLYQQ VIGTDPAPAN
     RRTWIVLRAD PERTRKSAQR RDEGVAGLAR YLVASATRIA DRLASHGVDA VCGRSFDDYD
     HATDIGFVRE KWSMIKGRDA YTAAYAAPGG PDVWWSARAD HTITRVRVAP GMAPQSTVLL
     TTADKPKTPR GFARLFGGQR PALQGQHLVA NRHCQLPIGS AGVLVGETVN RCPVYMPFDD
     VDIALNLGDA QTFTQFVVRA AAAGAMVTVG PQFEEFARLI GAHIGQEVKV AWPNATTYLG
     PHPGIDRVIL RHNVIGTPRH RQLPIRRVSP PEESRYQMAL PK