ECCE1_MYCTU
ID ECCE1_MYCTU Reviewed; 462 AA.
AC P9WJE9; L0TGW4; O05462; Q7D4N9;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 25-MAY-2022, entry version 32.
DE RecName: Full=ESX-1 secretion system protein EccE1 {ECO:0000305};
DE AltName: Full=ESX conserved component E1 {ECO:0000303|PubMed:19876390};
DE AltName: Full=Type VII secretion system protein EccE1 {ECO:0000305};
DE Short=T7SS protein EccE1 {ECO:0000305};
GN Name=eccE1 {ECO:0000303|PubMed:19876390};
GN Synonyms=snm7 {ECO:0000303|PubMed:16135231}; OrderedLocusNames=Rv3882c;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP INTERACTION WITH ESPD.
RC STRAIN=ATCC 35801 / TMC 107 / Erdman;
RX PubMed=16135231; DOI=10.1111/j.1365-2958.2005.04800.x;
RA MacGurn J.A., Raghavan S., Stanley S.A., Cox J.S.;
RT "A non-RD1 gene cluster is required for Snm secretion in Mycobacterium
RT tuberculosis.";
RL Mol. Microbiol. 57:1653-1663(2005).
RN [3]
RP IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].
RX PubMed=19099550; DOI=10.1186/1752-0509-2-109;
RA Raman K., Yeturu K., Chandra N.;
RT "targetTB: a target identification pipeline for Mycobacterium tuberculosis
RT through an interactome, reactome and genome-scale structural analysis.";
RL BMC Syst. Biol. 2:109-109(2008).
RN [4]
RP FUNCTION, SUBUNIT, AND NOMENCLATURE.
RX PubMed=19876390; DOI=10.1371/journal.ppat.1000507;
RA Bitter W., Houben E.N., Bottai D., Brodin P., Brown E.J., Cox J.S.,
RA Derbyshire K., Fortune S.M., Gao L.Y., Liu J., Gey van Pittius N.C.,
RA Pym A.S., Rubin E.J., Sherman D.R., Cole S.T., Brosch R.;
RT "Systematic genetic nomenclature for type VII secretion systems.";
RL PLoS Pathog. 5:E1000507-E1000507(2009).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT mass spectrometry.";
RL Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC -!- FUNCTION: Part of the ESX-1 specialized secretion system, which
CC delivers several virulence factors to host cells during infection,
CC including the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10).
CC {ECO:0000305|PubMed:19876390}.
CC -!- SUBUNIT: Part of the ESX-1 / type VII secretion system (T7SS), which is
CC composed of cytosolic and membrane components. The ESX-1 membrane
CC complex is composed of EccB1, EccCa1, EccCb1, EccD1 and EccE1
CC (PubMed:19876390). Interacts with EspD (PubMed:16135231).
CC {ECO:0000269|PubMed:16135231, ECO:0000305|PubMed:19876390}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000255}.
CC -!- MISCELLANEOUS: Was identified as a high-confidence drug target.
CC {ECO:0000269|PubMed:19099550}.
CC -!- SIMILARITY: Belongs to the EccE family. {ECO:0000305}.
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DR EMBL; AL123456; CCP46711.1; -; Genomic_DNA.
DR PIR; C70597; C70597.
DR RefSeq; NP_218399.1; NC_000962.3.
DR RefSeq; WP_003400000.1; NZ_NVQJ01000082.1.
DR AlphaFoldDB; P9WJE9; -.
DR STRING; 83332.Rv3882c; -.
DR PaxDb; P9WJE9; -.
DR DNASU; 886208; -.
DR GeneID; 45427885; -.
DR GeneID; 886208; -.
DR KEGG; mtu:Rv3882c; -.
DR TubercuList; Rv3882c; -.
DR eggNOG; ENOG5031ZQC; Bacteria.
DR OMA; RTWIMLR; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR InterPro; IPR021368; T7SS_EccE.
DR Pfam; PF11203; EccE; 1.
DR TIGRFAMs; TIGR03923; T7SS_EccE; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..462
FT /note="ESX-1 secretion system protein EccE1"
FT /id="PRO_0000393869"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 462 AA; 50397 MW; BB199AB9F8969E5F CRC64;
MRNPLGLRFS TGHALLASAL APPCIIAFLE TRYWWAGIAL ASLGVIVATV TFYGRRITGW
VAAVYAWLRR RRRPPDSSSE PVVGATVKPG DHVAVRWQGE FLVAVIELIP RPFTPTVIVD
GQAHTDDMLD TGLVEELLSV HCPDLEADIV SAGYRVGNTA APDVVSLYQQ VIGTDPAPAN
RRTWIVLRAD PERTRKSAQR RDEGVAGLAR YLVASATRIA DRLASHGVDA VCGRSFDDYD
HATDIGFVRE KWSMIKGRDA YTAAYAAPGG PDVWWSARAD HTITRVRVAP GMAPQSTVLL
TTADKPKTPR GFARLFGGQR PALQGQHLVA NRHCQLPIGS AGVLVGETVN RCPVYMPFDD
VDIALNLGDA QTFTQFVVRA AAAGAMVTVG PQFEEFARLI GAHIGQEVKV AWPNATTYLG
PHPGIDRVIL RHNVIGTPRH RQLPIRRVSP PEESRYQMAL PK
