ID   ECCE2_MYCTO             Reviewed;         537 AA.
AC   P9WJE6; L0TE26; O05459; Q8VIR5;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=ESX-2 secretion system protein EccE2;
DE   AltName: Full=ESX conserved component E2;
DE   AltName: Full=Type VII secretion system protein EccE2;
DE            Short=T7SS protein EccE2;
GN   Name=eccE2; OrderedLocusNames=MT4000;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- SUBUNIT: Could be part of the ESX-2 / type VII secretion system (T7SS),
CC       which is composed of cytosolic and membrane components. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the EccE family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK48368.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AE000516; AAK48368.1; ALT_FRAME; Genomic_DNA.
DR   PIR; F70597; F70597.
DR   RefSeq; WP_003902572.1; NZ_KK341228.1.
DR   AlphaFoldDB; P9WJE6; -.
DR   EnsemblBacteria; AAK48368; AAK48368; MT4000.
DR   GeneID; 45427888; -.
DR   KEGG; mtc:MT4000; -.
DR   PATRIC; fig|83331.31.peg.4305; -.
DR   HOGENOM; CLU_040158_0_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR021368; T7SS_EccE.
DR   Pfam; PF11203; EccE; 1.
DR   TIGRFAMs; TIGR03923; T7SS_EccE; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..537
FT                   /note="ESX-2 secretion system protein EccE2"
FT                   /id="PRO_0000427843"
FT   TRANSMEM        31..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   537 AA;  57656 MW;  9593A4D9D46D03E5 CRC64;
     MTSKLTGFSP RSARRVAGVW TVFVLASAGW ALGGQLGAVM AVVVGVALVF VQWWGQPAWS
     WAVLGLRGRR PVKWNDPITL ANNRSGGGVR VQDGVAVVAV QLLGRAHRAT TVTGSVTVES
     DNVIDVVELA PLLRHPLDLE LDSISVVTFG SRTGTVGDYP RVYDAEIGTP PYAGRRETWL
     IMRLPVIGNT QALRWRTSVG AAAISVAQRV ASSLRCQGLR AKLATATDLA ELDRRLGSDA
     VAGSAQRWKA IRGEAGWMTT YAYPAEAISS RVLSQAWTLR ADEVIQNVTV YPDATCTATI
     TVRTPTPAPT PPSVILRRLN GEQAAAAAAN MCGPRPHLRG QRRCPLPAQL VTEIGPSGVL
     IGKLSNGDRL MIPVTDAGEL SRVFVAADDT IAKRIVIRVV GAGERVCVHT RDQERWASVR
     MPQLSIVGTP RPAPRTTVGV VEYVRRRKNG DDGKSEGSGV DVAISPTPRP ASVITIARPG
     TSLSESDRHG FEVTIEQIDR ATVKVGAAGQ NWLVEMEMFR AENRYVSLEP VTMSIGR