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ECCE2_MYCTU
ID   ECCE2_MYCTU             Reviewed;         537 AA.
AC   P9WJE7; L0TE26; O05459; Q8VIR5;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 32.
DE   RecName: Full=ESX-2 secretion system protein EccE2;
DE   AltName: Full=ESX conserved component E2;
DE   AltName: Full=Type VII secretion system protein EccE2;
DE            Short=T7SS protein EccE2;
GN   Name=eccE2; OrderedLocusNames=Rv3885c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   GENE NAME.
RX   PubMed=19876390; DOI=10.1371/journal.ppat.1000507;
RA   Bitter W., Houben E.N., Bottai D., Brodin P., Brown E.J., Cox J.S.,
RA   Derbyshire K., Fortune S.M., Gao L.Y., Liu J., Gey van Pittius N.C.,
RA   Pym A.S., Rubin E.J., Sherman D.R., Cole S.T., Brosch R.;
RT   "Systematic genetic nomenclature for type VII secretion systems.";
RL   PLoS Pathog. 5:E1000507-E1000507(2009).
RN   [3]
RP   SUBUNIT.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=19854905; DOI=10.1128/jb.01032-09;
RA   Callahan B., Nguyen K., Collins A., Valdes K., Caplow M., Crossman D.K.,
RA   Steyn A.J., Eisele L., Derbyshire K.M.;
RT   "Conservation of structure and protein-protein interactions mediated by the
RT   secreted mycobacterial proteins EsxA, EsxB, and EspA.";
RL   J. Bacteriol. 192:326-335(2010).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SUBUNIT: Could be part of the ESX-2 / type VII secretion system (T7SS),
CC       which is composed of cytosolic and membrane components (By similarity).
CC       Residues 138-211 interact with an artificial EsxB-EsxA heterodimer from
CC       the adjacent ESX-1 locus (PubMed:19854905). {ECO:0000250,
CC       ECO:0000269|PubMed:19854905}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the EccE family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP46714.1; -; Genomic_DNA.
DR   PIR; F70597; F70597.
DR   RefSeq; NP_218402.1; NC_000962.3.
DR   RefSeq; WP_003902572.1; NZ_NVQJ01000082.1.
DR   AlphaFoldDB; P9WJE7; -.
DR   STRING; 83332.Rv3885c; -.
DR   PaxDb; P9WJE7; -.
DR   DNASU; 886220; -.
DR   GeneID; 45427888; -.
DR   GeneID; 886220; -.
DR   KEGG; mtu:Rv3885c; -.
DR   TubercuList; Rv3885c; -.
DR   eggNOG; ENOG5032GIB; Bacteria.
DR   OMA; PPYAGQR; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   InterPro; IPR021368; T7SS_EccE.
DR   Pfam; PF11203; EccE; 1.
DR   TIGRFAMs; TIGR03923; T7SS_EccE; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..537
FT                   /note="ESX-2 secretion system protein EccE2"
FT                   /id="PRO_0000393870"
FT   TRANSMEM        31..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   537 AA;  57656 MW;  9593A4D9D46D03E5 CRC64;
     MTSKLTGFSP RSARRVAGVW TVFVLASAGW ALGGQLGAVM AVVVGVALVF VQWWGQPAWS
     WAVLGLRGRR PVKWNDPITL ANNRSGGGVR VQDGVAVVAV QLLGRAHRAT TVTGSVTVES
     DNVIDVVELA PLLRHPLDLE LDSISVVTFG SRTGTVGDYP RVYDAEIGTP PYAGRRETWL
     IMRLPVIGNT QALRWRTSVG AAAISVAQRV ASSLRCQGLR AKLATATDLA ELDRRLGSDA
     VAGSAQRWKA IRGEAGWMTT YAYPAEAISS RVLSQAWTLR ADEVIQNVTV YPDATCTATI
     TVRTPTPAPT PPSVILRRLN GEQAAAAAAN MCGPRPHLRG QRRCPLPAQL VTEIGPSGVL
     IGKLSNGDRL MIPVTDAGEL SRVFVAADDT IAKRIVIRVV GAGERVCVHT RDQERWASVR
     MPQLSIVGTP RPAPRTTVGV VEYVRRRKNG DDGKSEGSGV DVAISPTPRP ASVITIARPG
     TSLSESDRHG FEVTIEQIDR ATVKVGAAGQ NWLVEMEMFR AENRYVSLEP VTMSIGR
 
 
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