ECCE2_MYCTU
ID ECCE2_MYCTU Reviewed; 537 AA.
AC P9WJE7; L0TE26; O05459; Q8VIR5;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 25-MAY-2022, entry version 32.
DE RecName: Full=ESX-2 secretion system protein EccE2;
DE AltName: Full=ESX conserved component E2;
DE AltName: Full=Type VII secretion system protein EccE2;
DE Short=T7SS protein EccE2;
GN Name=eccE2; OrderedLocusNames=Rv3885c;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP GENE NAME.
RX PubMed=19876390; DOI=10.1371/journal.ppat.1000507;
RA Bitter W., Houben E.N., Bottai D., Brodin P., Brown E.J., Cox J.S.,
RA Derbyshire K., Fortune S.M., Gao L.Y., Liu J., Gey van Pittius N.C.,
RA Pym A.S., Rubin E.J., Sherman D.R., Cole S.T., Brosch R.;
RT "Systematic genetic nomenclature for type VII secretion systems.";
RL PLoS Pathog. 5:E1000507-E1000507(2009).
RN [3]
RP SUBUNIT.
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=19854905; DOI=10.1128/jb.01032-09;
RA Callahan B., Nguyen K., Collins A., Valdes K., Caplow M., Crossman D.K.,
RA Steyn A.J., Eisele L., Derbyshire K.M.;
RT "Conservation of structure and protein-protein interactions mediated by the
RT secreted mycobacterial proteins EsxA, EsxB, and EspA.";
RL J. Bacteriol. 192:326-335(2010).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT mass spectrometry.";
RL Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC -!- SUBUNIT: Could be part of the ESX-2 / type VII secretion system (T7SS),
CC which is composed of cytosolic and membrane components (By similarity).
CC Residues 138-211 interact with an artificial EsxB-EsxA heterodimer from
CC the adjacent ESX-1 locus (PubMed:19854905). {ECO:0000250,
CC ECO:0000269|PubMed:19854905}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the EccE family. {ECO:0000305}.
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DR EMBL; AL123456; CCP46714.1; -; Genomic_DNA.
DR PIR; F70597; F70597.
DR RefSeq; NP_218402.1; NC_000962.3.
DR RefSeq; WP_003902572.1; NZ_NVQJ01000082.1.
DR AlphaFoldDB; P9WJE7; -.
DR STRING; 83332.Rv3885c; -.
DR PaxDb; P9WJE7; -.
DR DNASU; 886220; -.
DR GeneID; 45427888; -.
DR GeneID; 886220; -.
DR KEGG; mtu:Rv3885c; -.
DR TubercuList; Rv3885c; -.
DR eggNOG; ENOG5032GIB; Bacteria.
DR OMA; PPYAGQR; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR InterPro; IPR021368; T7SS_EccE.
DR Pfam; PF11203; EccE; 1.
DR TIGRFAMs; TIGR03923; T7SS_EccE; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..537
FT /note="ESX-2 secretion system protein EccE2"
FT /id="PRO_0000393870"
FT TRANSMEM 31..51
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 537 AA; 57656 MW; 9593A4D9D46D03E5 CRC64;
MTSKLTGFSP RSARRVAGVW TVFVLASAGW ALGGQLGAVM AVVVGVALVF VQWWGQPAWS
WAVLGLRGRR PVKWNDPITL ANNRSGGGVR VQDGVAVVAV QLLGRAHRAT TVTGSVTVES
DNVIDVVELA PLLRHPLDLE LDSISVVTFG SRTGTVGDYP RVYDAEIGTP PYAGRRETWL
IMRLPVIGNT QALRWRTSVG AAAISVAQRV ASSLRCQGLR AKLATATDLA ELDRRLGSDA
VAGSAQRWKA IRGEAGWMTT YAYPAEAISS RVLSQAWTLR ADEVIQNVTV YPDATCTATI
TVRTPTPAPT PPSVILRRLN GEQAAAAAAN MCGPRPHLRG QRRCPLPAQL VTEIGPSGVL
IGKLSNGDRL MIPVTDAGEL SRVFVAADDT IAKRIVIRVV GAGERVCVHT RDQERWASVR
MPQLSIVGTP RPAPRTTVGV VEYVRRRKNG DDGKSEGSGV DVAISPTPRP ASVITIARPG
TSLSESDRHG FEVTIEQIDR ATVKVGAAGQ NWLVEMEMFR AENRYVSLEP VTMSIGR