ID   ECCE3_MYCTO             Reviewed;         331 AA.
AC   P9WJE4; L0T688; O53696; Q7DA30;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=ESX-3 secretion system protein EccE3 {ECO:0000250|UniProtKB:P9WJE5};
DE   AltName: Full=ESX conserved component E3 {ECO:0000250|UniProtKB:P9WJE5};
DE   AltName: Full=Type VII secretion system protein EccE3 {ECO:0000250|UniProtKB:P9WJE5};
DE            Short=T7SS protein EccE3 {ECO:0000250|UniProtKB:P9WJE5};
GN   Name=eccE3 {ECO:0000250|UniProtKB:P9WJE5}; OrderedLocusNames=MT0305;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Part of the ESX-3 specialized secretion system, which is
CC       important for iron and zinc uptake or homeostasis.
CC       {ECO:0000250|UniProtKB:P9WJE5}.
CC   -!- SUBUNIT: Part of the ESX-3 / type VII secretion system (T7SS), which is
CC       composed of cytosolic and membrane components. The ESX-3 membrane
CC       complex is composed of EccB3, EccC3, EccD3 and EccE3.
CC       {ECO:0000250|UniProtKB:B2HSU8}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000250|UniProtKB:B2HSU8}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the EccE family. {ECO:0000305}.
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DR   EMBL; AE000516; AAK44529.1; -; Genomic_DNA.
DR   PIR; B70837; B70837.
DR   RefSeq; WP_003401533.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WJE4; -.
DR   SMR; P9WJE4; -.
DR   EnsemblBacteria; AAK44529; AAK44529; MT0305.
DR   GeneID; 45424266; -.
DR   KEGG; mtc:MT0305; -.
DR   PATRIC; fig|83331.31.peg.328; -.
DR   HOGENOM; CLU_079041_0_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR021368; T7SS_EccE.
DR   Pfam; PF11203; EccE; 1.
DR   TIGRFAMs; TIGR03923; T7SS_EccE; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..331
FT                   /note="ESX-3 secretion system protein EccE3"
FT                   /id="PRO_0000427844"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        37..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   331 AA;  35933 MW;  49984F90B99DEF01 CRC64;
     MNPIPSWPGR GRVTLVLLAV VPVALAYPWQ STRDYVLLGV AAAVVIGLFG FWRGLYFTTI
     ARRGLAILRR RRRIAEPATC TRTTVLVWVG PPASDTNVLP LTLIARYLDR YGIRADTIRI
     TSRVTASGDC RTWVGLTVVA DDNLAALQAR SARIPLQETA QVAARRLADH LREIGWEAGT
     AAPDEIPALV AADSRETWRG MRHTDSDYVA AYRVSADAEL PDTLPAIRSR PAQETWIALE
     IAYAAGSSTR YTVAAACALR TDWRPGGTAP VAGLLPQHGN HVPALTALDP RSTRRLDGHT
     DAPADLLTRL HWPTPTAGAH RAPLTNAVSR T