ID   ECCE5_MYCMM             Reviewed;         403 AA.
AC   B2HSU8;
DT   11-NOV-2015, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=ESX-5 secretion system protein EccE5 {ECO:0000305};
DE   AltName: Full=ESX conserved component E5 {ECO:0000305};
DE   AltName: Full=Type VII secretion system protein EccE5 {ECO:0000305};
DE            Short=T7SS protein EccE5 {ECO:0000305};
GN   Name=eccE5 {ECO:0000303|PubMed:22925462};
GN   OrderedLocusNames=MMAR_2679 {ECO:0000312|EMBL:ACC41122.1};
OS   Mycobacterium marinum (strain ATCC BAA-535 / M).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=216594;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-535 / M;
RX   PubMed=18403782; DOI=10.1101/gr.075069.107;
RA   Stinear T.P., Seemann T., Harrison P.F., Jenkin G.A., Davies J.K.,
RA   Johnson P.D., Abdellah Z., Arrowsmith C., Chillingworth T., Churcher C.,
RA   Clarke K., Cronin A., Davis P., Goodhead I., Holroyd N., Jagels K.,
RA   Lord A., Moule S., Mungall K., Norbertczak H., Quail M.A.,
RA   Rabbinowitsch E., Walker D., White B., Whitehead S., Small P.L., Brosch R.,
RA   Ramakrishnan L., Fischbach M.A., Parkhill J., Cole S.T.;
RT   "Insights from the complete genome sequence of Mycobacterium marinum on the
RT   evolution of Mycobacterium tuberculosis.";
RL   Genome Res. 18:729-741(2008).
RN   [2]
RP   FUNCTION.
RX   PubMed=19602152; DOI=10.1111/j.1365-2958.2009.06783.x;
RA   Abdallah A.M., Verboom T., Weerdenburg E.M., Gey van Pittius N.C.,
RA   Mahasha P.W., Jimenez C., Parra M., Cadieux N., Brennan M.J.,
RA   Appelmelk B.J., Bitter W.;
RT   "PPE and PE_PGRS proteins of Mycobacterium marinum are transported via the
RT   type VII secretion system ESX-5.";
RL   Mol. Microbiol. 73:329-340(2009).
RN   [3]
RP   FUNCTION, SUBUNIT, AND SUBCELLULAR LOCATION.
RC   STRAIN=ATCC BAA-535 / M;
RX   PubMed=22925462; DOI=10.1111/j.1365-2958.2012.08206.x;
RA   Houben E.N., Bestebroer J., Ummels R., Wilson L., Piersma S.R.,
RA   Jimenez C.R., Ottenhoff T.H., Luirink J., Bitter W.;
RT   "Composition of the type VII secretion system membrane complex.";
RL   Mol. Microbiol. 86:472-484(2012).
CC   -!- FUNCTION: Part of the ESX-5 specialized secretion system, which is
CC       responsible for the secretion of EsxN and a number of PE_PGRS and PPE
CC       proteins. {ECO:0000269|PubMed:19602152, ECO:0000269|PubMed:22925462}.
CC   -!- SUBUNIT: Part of the ESX-5 / type VII secretion system (T7SS), which is
CC       composed of cytosolic and membrane components. The ESX-5 membrane
CC       complex is composed of EccB5, EccC5, EccD5 and EccE5.
CC       {ECO:0000269|PubMed:22925462}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000269|PubMed:22925462}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the EccE family. {ECO:0000305}.
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DR   EMBL; CP000854; ACC41122.1; -; Genomic_DNA.
DR   RefSeq; WP_012394393.1; NC_010612.1.
DR   AlphaFoldDB; B2HSU8; -.
DR   STRING; 216594.MMAR_2679; -.
DR   EnsemblBacteria; ACC41122; ACC41122; MMAR_2679.
DR   GeneID; 64261392; -.
DR   KEGG; mmi:MMAR_2679; -.
DR   eggNOG; ENOG5031ZQB; Bacteria.
DR   HOGENOM; CLU_677612_0_0_11; -.
DR   OMA; LWDWSAD; -.
DR   OrthoDB; 529892at2; -.
DR   Proteomes; UP000001190; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR021368; T7SS_EccE.
DR   Pfam; PF11203; EccE; 1.
DR   TIGRFAMs; TIGR03923; T7SS_EccE; 1.
PE   1: Evidence at protein level;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..403
FT                   /note="ESX-5 secretion system protein EccE5"
FT                   /id="PRO_0000434752"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   403 AA;  43961 MW;  D09AED81E14B4340 CRC64;
     MKAQRRFGLA LSWARLTTVF VIDLLILIVA SHCPDSWQGE NRIAWWVGVG IAVLVTLLSV
     VTYRGITVTS GITAWLWDWS ADPGTALGAG CTPAVDHQRR FGRDTVGVRE HHGRLVTVIT
     VDDGEGDAAG RHRHRTTQSA VVPVATVAEN LRQFDVQLDG VDIVTVEVRG GAEAARASAS
     LDEWGPEEWG MVGESPAANR RRTWLILRMN PQRNVAAIAS RDSLASTLVT ATERLAQVLD
     GQSCAARPLA ADELAEVDSA ILAELEPTWS RPGWRHLKHF NGYATSFWVT PADINAETLD
     EVWLSDAPEV GATVLTLRLV MRAGEPRLSA WVRYHSDERL PKELSVGLNR LTGRQLAAVR
     ASLPVPSTRA QLVVSSRELL DHDELELPVG QTQEHATSAT TGQ