ID   ECCE5_MYCTO             Reviewed;         406 AA.
AC   P9WJE2; L0T7X7; O53946; Q7D7Y2;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=ESX-5 secretion system protein EccE5 {ECO:0000250|UniProtKB:P9WJE3};
DE   AltName: Full=ESX conserved component E5 {ECO:0000250|UniProtKB:P9WJE3};
DE   AltName: Full=Type VII secretion system protein EccE5 {ECO:0000250|UniProtKB:P9WJE3};
DE            Short=T7SS protein EccE5 {ECO:0000250|UniProtKB:P9WJE3};
GN   Name=eccE5 {ECO:0000250|UniProtKB:P9WJE3}; OrderedLocusNames=MT1846;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Part of the ESX-5 specialized secretion system, which is
CC       responsible for the secretion of EsxN and a number of PE_PGRS and PPE
CC       proteins, including PPE41. {ECO:0000250|UniProtKB:P9WJE3}.
CC   -!- SUBUNIT: Part of the ESX-5 / type VII secretion system (T7SS), which is
CC       composed of cytosolic and membrane components. The ESX-5 membrane
CC       complex is composed of EccB5, EccC5, EccD5 and EccE5.
CC       {ECO:0000250|UniProtKB:B2HSU8}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000250|UniProtKB:B2HSU8}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the EccE family. {ECO:0000305}.
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DR   EMBL; AE000516; AAK46117.1; -; Genomic_DNA.
DR   PIR; F70930; F70930.
DR   RefSeq; WP_003408859.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WJE2; -.
DR   EnsemblBacteria; AAK46117; AAK46117; MT1846.
DR   GeneID; 45425774; -.
DR   KEGG; mtc:MT1846; -.
DR   PATRIC; fig|83331.31.peg.1988; -.
DR   HOGENOM; CLU_677612_0_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR021368; T7SS_EccE.
DR   Pfam; PF11203; EccE; 1.
DR   TIGRFAMs; TIGR03923; T7SS_EccE; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..406
FT                   /note="ESX-5 secretion system protein EccE5"
FT                   /id="PRO_0000427845"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   406 AA;  44178 MW;  A49F3DEA437B97E9 CRC64;
     MKAQRSFGLA LSWPRVTAVF LVDVLILAVA SHCPDSWQAD HHVAWWVGVG VAAVVTLLSV
     VSYHGITVIS GLATWVRDWS ADPGTTLGAG CTPAIDHQRR FGRDTVGVRE YNGRLVSVIE
     VTCGESGPSG RHWHRKSPVP MLPVVAVADG LRQFDIHLDG IDIVSVLVRG GVDAAKASAS
     LQEWEPQGWK SEERAGDRTV ADRRRTWLVL RMNPQRNVAA VACRDSLAST LVAATERLVQ
     DLDGQSCAAR PVTADELTEV DSAVLADLEP TWSRPGWRHL KHFNGYATSF WVTPSDITSE
     TLDELCLPDS PEVGTTVVTV RLTTRVGSPA LSAWVRYHSD TRLPKEVAAG LNRLTGRQLA
     AVRASLPAPT HRPLLVIPSR NLRDHDELVL PVGQELEHAT SSFVGQ