ECCE5_MYCTU
ID ECCE5_MYCTU Reviewed; 406 AA.
AC P9WJE3; L0T7X7; O53946; Q7D7Y2;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 25-MAY-2022, entry version 30.
DE RecName: Full=ESX-5 secretion system protein EccE5 {ECO:0000305};
DE AltName: Full=ESX conserved component E5 {ECO:0000303|PubMed:19876390};
DE AltName: Full=Type VII secretion system protein EccE5 {ECO:0000305};
DE Short=T7SS protein EccE5 {ECO:0000305};
GN Name=eccE5 {ECO:0000303|PubMed:19876390}; OrderedLocusNames=Rv1797;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP NOMENCLATURE.
RX PubMed=19876390; DOI=10.1371/journal.ppat.1000507;
RA Bitter W., Houben E.N., Bottai D., Brodin P., Brown E.J., Cox J.S.,
RA Derbyshire K., Fortune S.M., Gao L.Y., Liu J., Gey van Pittius N.C.,
RA Pym A.S., Rubin E.J., Sherman D.R., Cole S.T., Brosch R.;
RT "Systematic genetic nomenclature for type VII secretion systems.";
RL PLoS Pathog. 5:E1000507-E1000507(2009).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT mass spectrometry.";
RL Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
RN [4]
RP FUNCTION.
RC STRAIN=H37Rv;
RX PubMed=22340629; DOI=10.1111/j.1365-2958.2012.08001.x;
RA Bottai D., Di Luca M., Majlessi L., Frigui W., Simeone R., Sayes F.,
RA Bitter W., Brennan M.J., Leclerc C., Batoni G., Campa M., Brosch R.,
RA Esin S.;
RT "Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss
RT of PPE protein secretion, reduction of cell wall integrity and strong
RT attenuation.";
RL Mol. Microbiol. 83:1195-1209(2012).
RN [5]
RP FUNCTION.
RX PubMed=22925462; DOI=10.1111/j.1365-2958.2012.08206.x;
RA Houben E.N., Bestebroer J., Ummels R., Wilson L., Piersma S.R.,
RA Jimenez C.R., Ottenhoff T.H., Luirink J., Bitter W.;
RT "Composition of the type VII secretion system membrane complex.";
RL Mol. Microbiol. 86:472-484(2012).
CC -!- FUNCTION: Part of the ESX-5 specialized secretion system, which is
CC responsible for the secretion of EsxN and a number of PE_PGRS and PPE
CC proteins, including PPE41. {ECO:0000269|PubMed:22340629,
CC ECO:0000269|PubMed:22925462}.
CC -!- SUBUNIT: Part of the ESX-5 / type VII secretion system (T7SS), which is
CC composed of cytosolic and membrane components. The ESX-5 membrane
CC complex is composed of EccB5, EccC5, EccD5 and EccE5.
CC {ECO:0000250|UniProtKB:B2HSU8}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000250|UniProtKB:B2HSU8}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the EccE family. {ECO:0000305}.
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DR EMBL; AL123456; CCP44563.1; -; Genomic_DNA.
DR PIR; F70930; F70930.
DR RefSeq; NP_216313.1; NC_000962.3.
DR RefSeq; WP_003408859.1; NZ_NVQJ01000037.1.
DR AlphaFoldDB; P9WJE3; -.
DR STRING; 83332.Rv1797; -.
DR PaxDb; P9WJE3; -.
DR DNASU; 885452; -.
DR GeneID; 45425774; -.
DR GeneID; 885452; -.
DR KEGG; mtu:Rv1797; -.
DR TubercuList; Rv1797; -.
DR eggNOG; ENOG5031ZQB; Bacteria.
DR OMA; LWDWSAD; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0005829; C:cytosol; HDA:MTBBASE.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR InterPro; IPR021368; T7SS_EccE.
DR Pfam; PF11203; EccE; 1.
DR TIGRFAMs; TIGR03923; T7SS_EccE; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..406
FT /note="ESX-5 secretion system protein EccE5"
FT /id="PRO_0000393872"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 406 AA; 44178 MW; A49F3DEA437B97E9 CRC64;
MKAQRSFGLA LSWPRVTAVF LVDVLILAVA SHCPDSWQAD HHVAWWVGVG VAAVVTLLSV
VSYHGITVIS GLATWVRDWS ADPGTTLGAG CTPAIDHQRR FGRDTVGVRE YNGRLVSVIE
VTCGESGPSG RHWHRKSPVP MLPVVAVADG LRQFDIHLDG IDIVSVLVRG GVDAAKASAS
LQEWEPQGWK SEERAGDRTV ADRRRTWLVL RMNPQRNVAA VACRDSLAST LVAATERLVQ
DLDGQSCAAR PVTADELTEV DSAVLADLEP TWSRPGWRHL KHFNGYATSF WVTPSDITSE
TLDELCLPDS PEVGTTVVTV RLTTRVGSPA LSAWVRYHSD TRLPKEVAAG LNRLTGRQLA
AVRASLPAPT HRPLLVIPSR NLRDHDELVL PVGQELEHAT SSFVGQ
