ECDB_ASPRU
ID ECDB_ASPRU Reviewed; 545 AA.
AC K0E2F6;
DT 25-APR-2018, integrated into UniProtKB/Swiss-Prot.
DT 28-NOV-2012, sequence version 1.
DT 25-MAY-2022, entry version 24.
DE RecName: Full=Putative transcription factor ecdB {ECO:0000303|PubMed:22998630};
GN Name=ecdB {ECO:0000303|PubMed:22998630};
OS Aspergillus rugulosus (Emericella rugulosa).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=41736;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 58397 / NRRL 11440;
RX PubMed=22998630; DOI=10.1021/ja307220z;
RA Cacho R.A., Jiang W., Chooi Y.H., Walsh C.T., Tang Y.;
RT "Identification and characterization of the echinocandin B biosynthetic
RT gene cluster from Emericella rugulosa NRRL 11440.";
RL J. Am. Chem. Soc. 134:16781-16790(2012).
RN [2]
RP CLUSTER REVISION.
RX PubMed=27502607; DOI=10.1186/s12864-016-2885-x;
RA Huettel W., Youssar L., Gruening B.A., Guenther S., Hugentobler K.G.;
RT "Echinocandin B biosynthesis: a biosynthetic cluster from Aspergillus
RT nidulans NRRL 8112 and reassembly of the subclusters Ecd and Hty from
RT Aspergillus pachycristatus NRRL 11440 reveals a single coherent gene
RT cluster.";
RL BMC Genomics 17:570-570(2016).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC -!- CAUTION: EcdB, ecdC, ecdD, ecdE and ecdF have previously been
CC identified as being part of the echinocandin B biosynthetic cluster,
CC but it was later realized that this was due to a genome misassembly and
CC these 5 proteins are now considered as artifacts and not part of the
CC cluster. {ECO:0000269|PubMed:27502607}.
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DR EMBL; JX421684; AFT91385.1; -; Genomic_DNA.
DR AlphaFoldDB; K0E2F6; -.
DR SMR; K0E2F6; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd00067; GAL4; 1.
DR Gene3D; 4.10.240.10; -; 1.
DR InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR Pfam; PF00172; Zn_clus; 1.
DR SMART; SM00066; GAL4; 1.
DR SUPFAM; SSF57701; SSF57701; 1.
DR PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Metal-binding; Nucleus; Transcription;
KW Transcription regulation; Zinc.
FT CHAIN 1..545
FT /note="Putative transcription factor ecdB"
FT /id="PRO_0000443827"
FT DNA_BIND 12..39
FT /note="Zn(2)-C6 fungal-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT REGION 79..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 545 AA; 60610 MW; CBF03EE1544618F7 CRC64;
MVKMRKRLAV ACDACRSRRV KCDGQRPSCM GCLSRGLDCS YQRLPEPPAT RLETELANVN
MRLDYLAMLL SRQSQPQAPP PVLLASARPS SNPLSSHEDS PFRLLATDSI MSVLGLEDHF
ARRLVQLERA SLLASTTTLS RMFFISHQQV TDALIAFSER VHTFYPILPL DFSERYFATL
SGPLAPSCQT CLALLVAAIG CIARDPTMGD EYFEAALASL PTVLAECTLA SIQCLVFLSI
YYCCRLKPCQ AHDYCLIASF KIQNLFKSEL SVQLDVATSD TWKLDEYIPL PNCRYTWQFS
CPPLPGNLAG VSPESASSSS SSISIDSTNS STSTASDQAQ SFFLAEIAMR RMLHRCNSAV
AQSSDGRFCY APSIALELER QLEEWYDYLP ASIRFVREPA GGSFNGDQSA LSPLSTFLNV
QYCCCKLSIY WPAVYQVIQD DKATPQLLEH CQRFIDSYVQ LLPRIALAID KCLIYKWTLS
VTFFVTTMAA LKVANTAALR AAQHERLHES LALAGTVGWK NTEDSPSLEL LRLNLSQHLR
EAKQK