位置:首页 > 蛋白库 > ADPRH_STAAM
ADPRH_STAAM
ID   ADPRH_STAAM             Reviewed;         266 AA.
AC   P67343; Q99WQ1;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Protein-ADP-ribose hydrolase {ECO:0000305|PubMed:26166706};
DE            Short=SpyMacroD {ECO:0000250|UniProtKB:P0DN70};
DE            EC=3.2.1.- {ECO:0000269|PubMed:26166706};
GN   OrderedLocusNames=SAV0325;
OS   Staphylococcus aureus (strain Mu50 / ATCC 700699).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=158878;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mu50 / ATCC 700699;
RX   PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA   Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA   Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA   Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA   Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL   Lancet 357:1225-1240(2001).
RN   [2]
RP   FUNCTION, AND CATALYTIC ACTIVITY.
RC   STRAIN=Mu50 / ATCC 700699;
RX   PubMed=26166706; DOI=10.1016/j.molcel.2015.06.013;
RA   Rack J.G., Morra R., Barkauskaite E., Kraehenbuehl R., Ariza A., Qu Y.,
RA   Ortmayer M., Leidecker O., Cameron D.R., Matic I., Peleg A.Y., Leys D.,
RA   Traven A., Ahel I.;
RT   "Identification of a class of protein ADP-ribosylating sirtuins in
RT   microbial pathogens.";
RL   Mol. Cell 59:309-320(2015).
CC   -!- FUNCTION: ADP-ribose glycohydrolase that hydrolyzes ADP-ribosyl-
CC       cysteine bonds (By similarity). Specifically reverses the SirTM-
CC       mediated mono-ADP-ribosylation of GcvH-L (SAV0324), by releasing ADP-
CC       ribose from the target protein. May be involved in the modulation of
CC       the response to host-derived oxidative stress.
CC       {ECO:0000250|UniProtKB:P0DN70, ECO:0000269|PubMed:26166706}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + H2O = ADP-D-ribose
CC         + H(+) + L-aspartyl-[protein]; Xref=Rhea:RHEA:54428, Rhea:RHEA-
CC         COMP:9867, Rhea:RHEA-COMP:13832, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29961, ChEBI:CHEBI:57967,
CC         ChEBI:CHEBI:138102; Evidence={ECO:0000269|PubMed:26166706};
CC   -!- SUBUNIT: Directly interacts with the lipoylated form of GcvH-L.
CC       {ECO:0000250|UniProtKB:P0DN70}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BA000017; BAB56487.1; -; Genomic_DNA.
DR   RefSeq; WP_000449069.1; NC_002758.2.
DR   AlphaFoldDB; P67343; -.
DR   SMR; P67343; -.
DR   PaxDb; P67343; -.
DR   EnsemblBacteria; BAB56487; BAB56487; SAV0325.
DR   KEGG; sav:SAV0325; -.
DR   HOGENOM; CLU_046550_2_1_9; -.
DR   OMA; AQRFSND; -.
DR   PhylomeDB; P67343; -.
DR   BioCyc; SAUR158878:SAV_RS01810-MON; -.
DR   Proteomes; UP000002481; Chromosome.
DR   GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IDA:UniProtKB.
DR   GO; GO:0051725; P:protein de-ADP-ribosylation; IDA:UniProtKB.
DR   CDD; cd02906; Macro_1; 1.
DR   Gene3D; 3.40.220.10; -; 1.
DR   InterPro; IPR035801; Macro_1.
DR   InterPro; IPR002589; Macro_dom.
DR   InterPro; IPR043472; Macro_dom-like.
DR   Pfam; PF01661; Macro; 1.
DR   SMART; SM00506; A1pp; 1.
DR   SUPFAM; SSF52949; SSF52949; 1.
DR   PROSITE; PS51154; MACRO; 1.
PE   1: Evidence at protein level;
KW   Glycosidase; Hydrolase.
FT   CHAIN           1..266
FT                   /note="Protein-ADP-ribose hydrolase"
FT                   /id="PRO_0000089209"
FT   DOMAIN          74..265
FT                   /note="Macro"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00490"
SQ   SEQUENCE   266 AA;  30110 MW;  5BB7528F6BC4F16B CRC64;
     METLKSNKAR LEYLINDMRR ERNDNDVLVM PSSFEDLWEL YRGLANVRPA LPVSDEYLAV
     QDAMLSDLNH QHVTDLKDLK PIKGDNIFVW QGDITTLKID AIVNAANSRF LGCMQANHDC
     IDNIIHTKAG VQVRLDCAEI IRQQGRNEGV GKAKKTRGYN LPAKYIIHTV GPQIRRLPVS
     KMNQDLLAKC YLSCLKLADQ HSLNHVAFCC ISTGVFAFPQ DEAAEIAVRT VESYLKETNS
     TLKVVFNVFT DKDLQLYKEA LNRDAE
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024