ID   ECD_DICDI               Reviewed;         819 AA.
AC   Q54JR9;
DT   16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Protein ecdysoneless homolog {ECO:0000250|UniProtKB:Q9W032};
GN   Name=ecd {ECO:0000312|dictyBase:DDB_G0287829};
GN   Synonyms=sgt1 {ECO:0000312|dictyBase:DDB_G0287829}; ORFNames=DDB_G0287829;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: May act as a transcriptional activator. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ECD family. {ECO:0000305}.
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DR   EMBL; AAFI02000104; EAL63561.1; -; Genomic_DNA.
DR   RefSeq; XP_637083.1; XM_631991.1.
DR   AlphaFoldDB; Q54JR9; -.
DR   STRING; 44689.DDB0238063; -.
DR   PaxDb; Q54JR9; -.
DR   PRIDE; Q54JR9; -.
DR   EnsemblProtists; EAL63561; EAL63561; DDB_G0287829.
DR   GeneID; 8626338; -.
DR   KEGG; ddi:DDB_G0287829; -.
DR   dictyBase; DDB_G0287829; ecd.
DR   eggNOG; KOG2406; Eukaryota.
DR   HOGENOM; CLU_318434_0_0_1; -.
DR   InParanoid; Q54JR9; -.
DR   OMA; DPRTGWN; -.
DR   PRO; PR:Q54JR9; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   InterPro; IPR010770; Ecd.
DR   PANTHER; PTHR13060; PTHR13060; 1.
DR   Pfam; PF07093; SGT1; 1.
PE   3: Inferred from homology;
KW   Activator; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..819
FT                   /note="Protein ecdysoneless homolog"
FT                   /id="PRO_0000356841"
FT   REGION          494..558
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          578..603
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          617..680
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          725..749
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          778..819
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        500..514
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        524..558
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        622..680
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   819 AA;  96147 MW;  BCC78DC413BE8A7D CRC64;
     MNKAKNSGAV PQFVDNFEDF YNNGDDILNN KHKEEINFVK YRIFDTHLIN YNNNNNNKNN
     NNNNNNNENT TITNKLNEIK EYLILNYIKD YIWQKEPFNL KIYDHKKKQQ QQQQLPIHFY
     GNTKFEESID DEWFIVYILL ELTKKFQSLI VSIKDNDGEF ILIETAQALP KWIKPTNSNN
     RVYLKNGEIH IIPLPSDPSQ LDTIPYKMDT NTALSILSSS SNNIITKVSN EINEILKNRL
     KRFYNGEYFL KDQNQIKLAA IPIEIGYLLN QYPQLISDIT TTFYNRDSDD MKTISTMKRF
     PMSRERDSFG NSGQLITTNI RFTRCLYAML KLQQWNSPKN FHPQLPKPSH PTYDSRSLGV
     KIICGLEMVY NRSKRNSVSS YHRFNDDLNW LNYLKQLKSN NYFNDETIGS KLYKEKLLIA
     KNQYLKNNIN NNNNNNNKEE ESIYKLIDQV TNSKSVDEMI KILQESDKSK IESEDDWLNE
     ENPDKFEDLI TEFENDRQKQ QQKQQQQQQQ QQQNKEGKKE VKENNNNNNN NNNNNNNNNN
     NNNNNNNNNN NDSNLINDFS NQFKSMLSQL SSFDGVEFNE KSGNSKNKTK SSAYGNGGDD
     NISFDSNKFM DILKGFTDNN KYDDDYDDDD DDDDDMYQDI DNYEDSDDKD DDEDDENDED
     DEDDGFEEYE DEDEDDDDEK EFQYVEFLKK STIKQYMERM DQELNLKIIA SSFELESTKL
     PKEFDDIEKS NNNNNNNINN NDKDVDEDDN ENYKVNQKVD LNLNLVKNLL ESLTEQQGFA
     GPASTLLKEM SDNNSKKREK KKTSSKKLIP KKGKVKENK