ID   ECFA2_UREPA             Reviewed;         433 AA.
AC   Q9PPV2;
DT   21-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Energy-coupling factor transporter ATP-binding protein EcfA2 {ECO:0000255|HAMAP-Rule:MF_01710};
DE            Short=ECF transporter A component EcfA2 {ECO:0000255|HAMAP-Rule:MF_01710};
DE            EC=3.6.3.- {ECO:0000255|HAMAP-Rule:MF_01710};
GN   Name=ecfA2 {ECO:0000255|HAMAP-Rule:MF_01710}; Synonyms=cbiO2;
GN   OrderedLocusNames=UU538;
OS   Ureaplasma parvum serovar 3 (strain ATCC 700970).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Ureaplasma.
OX   NCBI_TaxID=273119;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700970;
RX   PubMed=11048724; DOI=10.1038/35037619;
RA   Glass J.I., Lefkowitz E.J., Glass J.S., Heiner C.R., Chen E.Y.,
RA   Cassell G.H.;
RT   "The complete sequence of the mucosal pathogen Ureaplasma urealyticum.";
RL   Nature 407:757-762(2000).
CC   -!- FUNCTION: ATP-binding (A) component of a common energy-coupling factor
CC       (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF
CC       transporter provides the energy necessary to transport a number of
CC       different substrates. {ECO:0000255|HAMAP-Rule:MF_01710}.
CC   -!- SUBUNIT: Forms a stable energy-coupling factor (ECF) transporter
CC       complex composed of 2 membrane-embedded substrate-binding proteins (S
CC       component), 2 ATP-binding proteins (A component) and 2 transmembrane
CC       proteins (T component). {ECO:0000255|HAMAP-Rule:MF_01710}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01710};
CC       Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01710}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. Energy-coupling
CC       factor EcfA family. {ECO:0000255|HAMAP-Rule:MF_01710}.
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DR   EMBL; AF222894; AAF30951.1; -; Genomic_DNA.
DR   RefSeq; WP_006688554.1; NC_002162.1.
DR   AlphaFoldDB; Q9PPV2; -.
DR   SMR; Q9PPV2; -.
DR   STRING; 273119.UU538; -.
DR   EnsemblBacteria; AAF30951; AAF30951; UU538.
DR   GeneID; 29672424; -.
DR   KEGG; uur:UU538; -.
DR   eggNOG; COG1122; Bacteria.
DR   eggNOG; COG1132; Bacteria.
DR   HOGENOM; CLU_000604_1_22_14; -.
DR   OMA; QVHKYYG; -.
DR   Proteomes; UP000000423; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   CDD; cd03225; ABC_cobalt_CbiO_domain1; 1.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR015856; ABC_transpr_CbiO/EcfA_su.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR   PROSITE; PS51246; CBIO; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell membrane; Hydrolase; Membrane; Nucleotide-binding;
KW   Reference proteome; Transport.
FT   CHAIN           1..433
FT                   /note="Energy-coupling factor transporter ATP-binding
FT                   protein EcfA2"
FT                   /id="PRO_0000092124"
FT   DOMAIN          25..389
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01710"
FT   BINDING         62..69
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01710"
SQ   SEQUENCE   433 AA;  50401 MW;  465504D95A9B61D4 CRC64;
     MQKLMDYFFK RKLKVPRPIS NDISVRVKNL YAVYDEKQEN QLVALNNISY DFKKNKIYFI
     IGNSGSGKST LVTHFNGLMI SRYGFVQVGD IVSGDHFDFE RQLLGVIDSY DKKIINLLWR
     NQLDQWTFLV LFSNEVNIQQ ARILFEANFK QKPISLKFIK TKNNHELITN PYVRENTKIA
     VVRVDKNVIL EINDKMNYEE LQRFEFIKKE IKTNYHLSKK IKRFKELRRR VGFVFQFPEY
     QLFKDTIEKD IMFGPVNLGV KKSEAKKRAK FYLNKLGLGD DYLERSPFGL SGGQKRRVAI
     AGILAIQNDI LVFDEPTAGL DPAGEHEMMQ IILDAKANNK TVFVITHTME HVLEVADEVI
     VMDEGEIIKT GTPYEIFFDQ HIINSTSIQV PRVIAVINEL IKKDLKYEIL KQKQPRTIEE
     LADAIIEFKK GEK