ECFA_ENTFC
ID ECFA_ENTFC Reviewed; 279 AA.
AC Q8VNL9;
DT 21-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Energy-coupling factor transporter ATP-binding protein EcfA {ECO:0000255|HAMAP-Rule:MF_01710};
DE Short=ECF transporter A component EcfA {ECO:0000255|HAMAP-Rule:MF_01710};
DE EC=3.6.3.- {ECO:0000255|HAMAP-Rule:MF_01710};
GN Name=ecfA {ECO:0000255|HAMAP-Rule:MF_01710}; Synonyms=cbiO;
OS Enterococcus faecium (Streptococcus faecium).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=1352;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=12110480; DOI=10.1111/j.1574-695x.2002.tb00589.x;
RA Burnie J.P., Carter T.L., Rigg G.P., Hodgetts S.J., Donohoe M.S.,
RA Matthews R.C.;
RT "Identification of ABC transporters in vancomycin-resistant Enterococcus
RT faecium as potential targets for antibody therapy.";
RL FEMS Immunol. Med. Microbiol. 33:179-189(2002).
CC -!- FUNCTION: ATP-binding (A) component of a common energy-coupling factor
CC (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF
CC transporter provides the energy necessary to transport a number of
CC different substrates. {ECO:0000255|HAMAP-Rule:MF_01710}.
CC -!- SUBUNIT: Forms a stable energy-coupling factor (ECF) transporter
CC complex composed of 2 membrane-embedded substrate-binding proteins (S
CC component), 2 ATP-binding proteins (A component) and 2 transmembrane
CC proteins (T component). {ECO:0000255|HAMAP-Rule:MF_01710}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01710};
CC Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01710}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. Energy-coupling
CC factor EcfA family. {ECO:0000255|HAMAP-Rule:MF_01710}.
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DR EMBL; AJ428868; CAD21830.1; -; Genomic_DNA.
DR RefSeq; WP_002288720.1; NZ_WVTH01000008.1.
DR AlphaFoldDB; Q8VNL9; -.
DR SMR; Q8VNL9; -.
DR STRING; 1352.AL014_11760; -.
DR GeneID; 66453103; -.
DR eggNOG; COG1122; Bacteria.
DR OrthoDB; 1713578at2; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProt.
DR CDD; cd03225; ABC_cobalt_CbiO_domain1; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR015856; ABC_transpr_CbiO/EcfA_su.
DR InterPro; IPR030947; EcfA_1.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR04520; ECF_ATPase_1; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR PROSITE; PS51246; CBIO; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cell membrane; Hydrolase; Membrane; Nucleotide-binding;
KW Transport.
FT CHAIN 1..279
FT /note="Energy-coupling factor transporter ATP-binding
FT protein EcfA"
FT /id="PRO_0000092010"
FT DOMAIN 5..240
FT /note="ABC transporter"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01710"
FT BINDING 40..47
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01710"
SQ SEQUENCE 279 AA; 31163 MW; 989E5B00E15708FB CRC64;
MEPIIELEKI NYKYQPDDLR PALKDVSFTI DKGEWIAIIG HNGSGKSTLA KTINGLLLPE
SGIVKVGNQI LDEENIWTIR QMVGMVFQNP DNQFVGSTVE DDVAFGLENQ GIPREEMLVR
VKDALEKVRM AEFASREPAR LSGGQKQRVA IAGVVALRPD IIILDEATSM LDPEGREEVI
STIKKIKEES QLTVISITHD IDEAANANRI LVMRQGELVR EGTPKEIFSA GPELIDLGLD
LPFPEKLKSA LKERGVDVPS EYMTEERMVD WLWTSVLNK
