ID   ECFT_STAA4              Reviewed;         268 AA.
AC   D3ERJ1;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   23-MAR-2010, sequence version 1.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=Energy-coupling factor transporter transmembrane protein EcfT {ECO:0000255|HAMAP-Rule:MF_01461};
DE            Short=ECF transporter T component EcfT {ECO:0000255|HAMAP-Rule:MF_01461};
GN   Name=ecfT {ECO:0000255|HAMAP-Rule:MF_01461}; OrderedLocusNames=SA2981_2158;
OS   Staphylococcus aureus (strain 04-02981).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=703339;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=04-02981;
RX   PubMed=20386717; DOI=10.1371/journal.ppat.1000855;
RA   Nubel U., Dordel J., Kurt K., Strommenger B., Westh H., Shukla S.K.,
RA   Zemlickova H., Leblois R., Wirth T., Jombart T., Balloux F., Witte W.;
RT   "A timescale for evolution, population expansion, and spatial spread of an
RT   emerging clone of methicillin-resistant Staphylococcus aureus.";
RL   PLoS Pathog. 6:E1000855-E1000855(2010).
CC   -!- FUNCTION: Transmembrane (T) component of an energy-coupling factor
CC       (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF
CC       transporter provides the energy necessary to transport a number of
CC       different substrates. {ECO:0000255|HAMAP-Rule:MF_01461}.
CC   -!- SUBUNIT: Forms a stable energy-coupling factor (ECF) transporter
CC       complex composed of 2 membrane-embedded substrate-binding proteins (S
CC       component), 2 ATP-binding proteins (A component) and 2 transmembrane
CC       proteins (T component). May be able to interact with more than 1 S
CC       component at a time (By similarity). {ECO:0000255|HAMAP-Rule:MF_01461}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01461};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01461}.
CC   -!- SIMILARITY: Belongs to the energy-coupling factor EcfT family.
CC       {ECO:0000255|HAMAP-Rule:MF_01461}.
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DR   EMBL; CP001844; ADC38369.1; -; Genomic_DNA.
DR   RefSeq; WP_000791620.1; NC_017340.1.
DR   AlphaFoldDB; D3ERJ1; -.
DR   SMR; D3ERJ1; -.
DR   KEGG; suy:SA2981_2158; -.
DR   PATRIC; fig|703339.3.peg.2201; -.
DR   HOGENOM; CLU_056469_2_2_9; -.
DR   OMA; MKAQMSR; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01461; EcfT; 1.
DR   InterPro; IPR003339; ABC/ECF_trnsptr_transmembrane.
DR   InterPro; IPR024919; EcfT.
DR   Pfam; PF02361; CbiQ; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..268
FT                   /note="Energy-coupling factor transporter transmembrane
FT                   protein EcfT"
FT                   /id="PRO_0000409000"
FT   TRANSMEM        28..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01461"
FT   TRANSMEM        63..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01461"
FT   TRANSMEM        107..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01461"
FT   TRANSMEM        152..172
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01461"
FT   TRANSMEM        248..268
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01461"
SQ   SEQUENCE   268 AA;  30830 MW;  7A64D1C7334E69DF CRC64;
     MKNKLIIGRY LPINSFVHHL DPRAKLMFVF LFIILIFFCH SPLTYLWVFA LILFIMRLAK
     IQLWFLIKGL TPIFFFLIFT LMMHIFLTKG GYVLVEWHGI TIETNGILEG LYISLRLIGI
     VMIATIMTLS TSPIDLTDAF ERLLAPLKMF KLPVHQLSMI MSIALRFIPT LMDELDKIIL
     AQKSRGSEIS SGNIATRIKS FIPLLVPLFI SAFQRAEELA VAMEVRGYDA NVKRTSYRQL
     KWQLRDTISL TMIIPIAIIL FVLKYSGV