ID   ECH13_MYCTU             Reviewed;         318 AA.
AC   P95279; F2GGT0; I6Y7W5; Q7D7R5;
DT   30-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   25-MAY-2022, entry version 136.
DE   RecName: Full=Putative enoyl-CoA hydratase EchA13 {ECO:0000305};
GN   Name=echA13; OrderedLocusNames=Rv1935c;
GN   ORFNames=LH57_10530 {ECO:0000312|EMBL:AIR14680.1};
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27294 / TMC 102 / H37Rv;
RA   Hazbon M.H., Riojas M.A., Damon A.M., Alalade R.O., Cantwell B.J.,
RA   Monaco A., King S., Sohrabi A.;
RT   "Phylogenetic analysis of Mycobacterial species using whole genome
RT   sequences.";
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   INDUCTION.
RX   PubMed=19389781; DOI=10.1099/mic.0.027086-0;
RA   de la Paz Santangelo M., Klepp L., Nunez-Garcia J., Blanco F.C., Soria M.,
RA   Garcia-Pelayo M.C., Bianco M.V., Cataldi A.A., Golby P., Jackson M.,
RA   Gordon S.V., Bigi F.;
RT   "Mce3R, a TetR-type transcriptional repressor, controls the expression of a
RT   regulon involved in lipid metabolism in Mycobacterium tuberculosis.";
RL   Microbiology 155:2245-2255(2009).
CC   -!- INDUCTION: Repressed by Mce3R. {ECO:0000269|PubMed:19389781}.
CC   -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP009480; AIR14680.1; -; Genomic_DNA.
DR   EMBL; AL123456; CCP44702.1; -; Genomic_DNA.
DR   RefSeq; NP_216451.1; NC_000962.3.
DR   RefSeq; WP_003409707.1; NZ_NVQJ01000034.1.
DR   AlphaFoldDB; P95279; -.
DR   SMR; P95279; -.
DR   STRING; 83332.Rv1935c; -.
DR   PaxDb; P95279; -.
DR   PRIDE; P95279; -.
DR   DNASU; 885240; -.
DR   GeneID; 885240; -.
DR   KEGG; mtu:Rv1935c; -.
DR   PATRIC; fig|83332.111.peg.2153; -.
DR   TubercuList; Rv1935c; -.
DR   eggNOG; COG1024; Bacteria.
DR   HOGENOM; CLU_009834_7_3_11; -.
DR   OMA; PTYQCNG; -.
DR   PhylomeDB; P95279; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0004300; F:enoyl-CoA hydratase activity; IBA:GO_Central.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IBA:GO_Central.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   Pfam; PF00378; ECH_1; 2.
DR   SUPFAM; SSF52096; SSF52096; 1.
PE   2: Evidence at transcript level;
KW   Fatty acid metabolism; Lipid metabolism; Lyase; Reference proteome.
FT   CHAIN           1..318
FT                   /note="Putative enoyl-CoA hydratase EchA13"
FT                   /id="PRO_0000438539"
FT   REGION          90..110
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   318 AA;  35250 MW;  AD2F121E4987169F CRC64;
     MFVGRVGPVD RRSDGERSRR PREFEYIRYE TIDDGRIAAI TLDRPKQRNA QTRGMLVELG
     AAFELAEADD TVRVVILRAA GPAFSAGHDL GSADDIRERS PGPDQHPSYR CNGATFGGVE
     SRNRQEWHYY FENTKRWRNL RKITIAQVHG AVLSAGLMLA WCCDLIVASE DTVFADVVGT
     RLGMCGVEYF GHPWEFGPRK TKELLLTGDC IGADEAHALG MVSKVFPADE LATSTIEFAR
     RIAKVPTMAA LLIKESVNQT VDAMGFSAAL DGCFKIHQLN HAHWGEVTGG KLSYGTVEYG
     LEDWRAAPQI RPAIKQRP