ID   ECH17_MYCA1             Reviewed;         257 AA.
AC   A0QJH8;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Probable enoyl-CoA hydratase echA17;
DE            EC=4.2.1.17;
GN   Name=echA17; OrderedLocusNames=MAV_3904;
OS   Mycobacterium avium (strain 104).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium avium complex (MAC).
OX   NCBI_TaxID=243243;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=104;
RA   Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA   Fraser C.M.;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Could possibly oxidize fatty acids using specific components.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O;
CC         Xref=Rhea:RHEA:16105, ChEBI:CHEBI:15377, ChEBI:CHEBI:57318,
CC         ChEBI:CHEBI:58856; EC=4.2.1.17;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O;
CC         Xref=Rhea:RHEA:20724, ChEBI:CHEBI:15377, ChEBI:CHEBI:58521,
CC         ChEBI:CHEBI:137480; EC=4.2.1.17;
CC   -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC       {ECO:0000305}.
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DR   EMBL; CP000479; ABK65454.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0QJH8; -.
DR   SMR; A0QJH8; -.
DR   EnsemblBacteria; ABK65454; ABK65454; MAV_3904.
DR   KEGG; mav:MAV_3904; -.
DR   HOGENOM; CLU_009834_7_6_11; -.
DR   OMA; DERVFCA; -.
DR   Proteomes; UP000001574; Chromosome.
DR   GO; GO:0004300; F:enoyl-CoA hydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.12.10; -; 1.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR014748; Enoyl-CoA_hydra_C.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
PE   3: Inferred from homology;
KW   Fatty acid metabolism; Lipid metabolism; Lyase.
FT   CHAIN           1..257
FT                   /note="Probable enoyl-CoA hydratase echA17"
FT                   /id="PRO_0000383561"
FT   SITE            139
FT                   /note="Important for catalytic activity"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   257 AA;  26666 MW;  64C6E9835DFA169A CRC64;
     MAALNEFVSV VVSDGSRDAG LAMLLVSRPP TNALSRQVYR EVIAAADELG RRDDVAAVIL
     FGGHEIFSAG DDMPELRTLR GAEAETAARV RRDAIDAVAA IPKPTVAAIT GYALGAGLTL
     ALAADWRISG DNVKFGATEI LAGLVPGGDA LARLTRVAGA SKAKELVFSG RFFDAEEALA
     LGLIDEMVAP DDVYDAAAAW ARRFLDGPRH ALAAAKAGVD AVFELPRAER LAAGQRRYVE
     VFSAGQGGDA GADPHGG