ID   ECHA6_MYCLE             Reviewed;         247 AA.
AC   Q50130;
DT   29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 111.
DE   RecName: Full=Probable enoyl-CoA hydratase echA6;
DE            EC=4.2.1.17;
GN   Name=echA6; OrderedLocusNames=ML2118; ORFNames=u650af;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Smith D.R., Robison K.;
RL   Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- FUNCTION: Could possibly oxidize fatty acids using specific components.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O;
CC         Xref=Rhea:RHEA:16105, ChEBI:CHEBI:15377, ChEBI:CHEBI:57318,
CC         ChEBI:CHEBI:58856; EC=4.2.1.17;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O;
CC         Xref=Rhea:RHEA:20724, ChEBI:CHEBI:15377, ChEBI:CHEBI:58521,
CC         ChEBI:CHEBI:137480; EC=4.2.1.17;
CC   -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC       {ECO:0000305}.
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DR   EMBL; U15184; AAA63046.1; -; Genomic_DNA.
DR   EMBL; AL583924; CAC31073.1; -; Genomic_DNA.
DR   PIR; A87174; A87174.
DR   RefSeq; NP_302400.1; NC_002677.1.
DR   RefSeq; WP_010908720.1; NC_002677.1.
DR   AlphaFoldDB; Q50130; -.
DR   SMR; Q50130; -.
DR   STRING; 272631.ML2118; -.
DR   EnsemblBacteria; CAC31073; CAC31073; CAC31073.
DR   KEGG; mle:ML2118; -.
DR   PATRIC; fig|272631.5.peg.3996; -.
DR   Leproma; ML2118; -.
DR   eggNOG; COG1024; Bacteria.
DR   HOGENOM; CLU_009834_7_2_11; -.
DR   OMA; MHALPRI; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0004300; F:enoyl-CoA hydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR018376; Enoyl-CoA_hyd/isom_CS.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
DR   PROSITE; PS00166; ENOYL_COA_HYDRATASE; 1.
PE   3: Inferred from homology;
KW   Fatty acid metabolism; Lipid metabolism; Lyase; Reference proteome.
FT   CHAIN           1..247
FT                   /note="Probable enoyl-CoA hydratase echA6"
FT                   /id="PRO_0000109334"
SQ   SEQUENCE   247 AA;  26654 MW;  08D7A556ED006C0C CRC64;
     MIGITQAEGV MTIELQRPER RNALNSQLIE KLREAVQKAS SADSEVSTRV IVLTGQGTVF
     CAGADLSGDA FAADYPDRLI ELHRVMDAVP MPVIGAINGP AIGAGLQLAM QCDLRVVAPD
     AYFQFPTSKY GLALDNWSIR RLSSLVGHGR ARAMLLTAEK LTADIALQTG MANRIGALAD
     AQAWAAEVTG LAPLAIQHAK RVLNDDGSIE EAWPEHKKLF DKAWTSQDVI EAQVARVEKR
     PPKFQGA